Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18208876 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18275280 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18312481 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17894360 |
polymorphism of TLR9 gene is significantly associated patients with mold infections, suggesting a possible role for this genetic variant as a risk factor for mold infections in pediatric patients receiving chemotherapy for hematological diseases |
| 18036648 |
Autocrine TNF-alpha secretion resulting from IgE/FcepsilonRI-dependent activation plays a critical role in suppressing TLR9-dependent responses in plasmacytoid dendritic cells that normally promote T(H)1 activity |
| 17854755 |
Patients with severe and mild malaria showed increased surface expression of TLR2 and TLR4 on CD14(+)monocytes and myeloid dendritic cells and decreased intracellular expression of TLR9 on plasmacytoid dendritic cells compared to healthy controls. |
| 18092352 |
Benign prostate epithelial cells express both TLR 4 (LPS-specific) and TLR 9 (CpG-specific) when exposured to lipopolysaccharide (LPS) and CpG DNA. |
| 12573264 |
Observational study of genotype prevalence and gene-disease association. (HuGE Navigator) |
| 14987294 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15730519 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15878652 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16125159 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16164440 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16371473 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16437636 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 16575840 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16608528 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16779724 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16971956 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17258734 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17301562 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17344245 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17373355 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17482427 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 17516623 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17573724 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17854429 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17914947 |
Observational study and meta-analysis of gene-disease association. (HuGE Navigator) |
| 17964520 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 18160420 |
abnormality of innate immunity plays a crucial role in the pathology of sysemic lupus erythematosus: blockade of CpG-TLR9 interaction may be a new therapeutic approach. |
| 17932028 |
Btk as a key signaling molecule that interacts with and acts downstream of TLR8 and TLR9. |
| 17768129 |
Overexpression of TLR9 is associated with B-chronic lymphocytic leukemia |
| 17984204 |
an NF-kappaB luciferase reporter assay in human embryonic kidney cells transfected with human TLR9 demonstrated that Entamoeba histolytica DNA signaled through Toll-like receptor 9 (TLR9) in a manner similar to that seen with CpG-oligodeoxynucleotides. |
| 17914947 |
TLR9 variants were not major risk factors for Crohn's disease in New Zealand population, but may associations with disease worldwide. |
| 17854429 |
SNPs in the TLR9 gene were not significantly associated with susceptibility to Behcet's disease |
| 17516623 |
Our results do not indicate a major influence of these putative functional TLR5 and TLR9 single nucleotide polymorphisms on the susceptibility to (or protection from) systemic lupus erythematosus. |
| 17440926 |
TLR9 expression, which was mainly observed as cytoplasmic staining, gradually increased in accordance with the histopathological grade |
| 17878374 |
suggest the existence of an IRAK-4-independent TLR9-induced transduction pathway leading to PI3K activation |
| 17344245 |
The presence of the G allele at position +1174 of TLR9 predisposes humans to an increased risk of SLE. |
| 17636117 |
synthetic agonists of TLR9 interfere with growth and angiogenesis also by epidermal growth factor receptor- and antibody-dependent cell-mediated cytotoxicity-independent mechanisms affecting endothelial cell functions |
| 17573724 |
the TLR9 promoter polymorphism C-1237T might affect atopic eczema susceptibility in particular in patients with the intrinsic variant of AE |
| 17473064 |
TLR-9 may play a role in the regulation of the hypothalamic-pituitary-adrenal axis during conditions in which bacterial DNA is present. |
| 16779724 |
TLR4 and TLR9 polymorphisms increased the risk of low birth weight in infants; polymorphisms of TLR4 increased the risk of maternal anemia. |
| 12778475 |
A synergistic role is played by the TLR9/CD40 system in the orchestration of CpG-ODN-induced responses in B lymphocytes. |
| 12689944 |
normal and neoplastic human B lymphocytes express a distinct TLR repertoire including TLR9 and TLR10 and expression is increased upon engagement of the antigen receptor complex or TLR9 itself |
| 15294971 |
mechanism of TLR9 gene regulation |
| 16024265 |
results demonstrated that TLR9 expression is correlated with immune activation and differs between individuals with non-activated or chronically immune activated background |
| 16437636 |
significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of patients with a risk of developing chronic or refractory pouchitis |
| 17000223 |
reviews experience with two distinct therapeutic strategies: TLR9-based immunomodulation and TLR9-based vaccination |
| 17145922 |
immune cells use several mechanisms to discriminate between stimulatory and nonstimulatory DNA; however, it appears that TLR9 itself binds rather indiscriminately to a broad range of DNAs |
| 15631627 |
The expression of functionally active TLR9 in human malignant tumors might affect treatment approaches using CpG-ODN and shows that malignant cells can be regarded as active players in tumor-immunology. |
| 16125159 |
Data indicate that the two TLR-9 promotor polymorphisms are not involved in atherogenesis. |
| 16394009 |
Activation of TLR-9 induces IL-8 secretion through peroxynitrite signaling in neutrophils. |
| 15790341 |
The TLR9 was analyzed by ICS as it was reported to be expressed in an intracellular compartment. |
| 16424230 |
Broad TLR9 activation defects in common variable immune deficiency prevent CpG-DNA-initiated innate immune responses; these defects may lead to impaired responses of plasmacytoid dendritic cells and loss of B cell function. |
| 12560217 |
In naive B cells, the expression of TLR9 and TLR10 is rapidly induced following B-cell-receptor (BCR) triggering. In contrast, memory B cells express several TLRs at constitutively high levels. |
| 15730519 |
TLR9 gene polymorphisms were not significantly associated with the susceptibility to systemic lupus erythematosus in Korean patients. |
| 16237063 |
TLR9- and FcepsilonRI-mediated responses oppose one another in plasmacytoid dendritic cells by down-regulating receptor expression. |
| 11867692 |
TLR9 acts at the cell surface and engages an intracellular signaling pathway that includes MyD88, IRAK, and TRAF6 |
| 11976718 |
Toll-like receptor 9 functions in the activation of RF expressing B-cells. |
| 16428738 |
Bacterial DNA preparations from different species differ in their capacity to activate TLR-9, which is dependent on the individual [CG] content. Moreover, increased intracellular delivery results in a marked enhancement of immunostimulation. |
| 16920494 |
Plays a role of in the recognition of M. bovis BCG by dendritic cells. |
| 17373717 |
TLR9-mediated invasion may represent a novel mechanism through which infections promote prostate cancer. |
| 12600829 |
All nine patients expressed all of the TLRs studied, whereas only five out of the nine patients had any granulomas positive for IL-4.The associations between TLRs 1, 5, and 9 were different in IL-4-negative compared with IL-4-positive patients. |
| 16864658 |
This establishes that the primary determinant of TLR9 signaling is not valency but endosomal location and demonstrates a strict compartmentalization of the biological response to TLR9 activation in plasmacytoid dendritic cells (PDCs). |
| 16990271 |
The results of this study suggest a model where modification of the cytoplasmic tail of TLR9 results in trafficking to early endosomes where it encounters CpG DNA. |
| 17328813 |
The widespread expression of TLR9 in the nasal mucosa along with its rich representation in leukocytes in different compartments. |
| 15607737 |
Moreover, the TLR9 transfectant demonstrated its usefulness for evaluation of immunostimulation by bacterial DNA through the detection of T(H)-1, T(H)-2 type cytokine induction via TLR9 signaling. |
| 16847112 |
findings demonstrate that TLR-3 and TLR-9 mediate the activation of corneal cells by Herpes simplex virus 1, HSV-1 DNA and HSV-1-antibody complexes |
| 16951309 |
TLR2 and TLR9 cooperate in the control of parasite replication during Trypanosoma cruzi infection; TLR9 has a primary role in the MyD88-dependent induction of IL-12/IFN-gamma synthesis during infection with T. cruzi. |
| 17040905 |
TLR8 inhibits TLR7 and TLR9, and TLR9 inhibits TLR7 but not vice versa in HEK293 cells transfected with TLRs in a pairwise combination. |
| 14694183 |
peptidoglycan signaling through TLR2 and bacterial CpG DNA signaling through TLR9 are functionally equivalent at synergizing with IFN-gamma in regulating Tap-1 expression in macrophages |
| 15307186 |
Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner. |
| 16002719 |
Diminished expression and function of TLR9 is a likely consequence of chronic filarial antigen stimulation and could serve as a novel mechanism underlying the dysfunctional immune response in lymphatic filariasis |
| 17075805 |
In patients with active systemic lupus erythematosus, the proportion of peripheral blood memory B cells and plasma cells expressing TLR-9 is increased |
| 17142771 |
HMGB1 suppresses PDC cytokine secretion and maturation in response to TLR9 agonists including the hypomethylated oligodeoxynucleotide CpG- and DNA-containing viruses |
| 17229603 |
Development of skin lesions in mycosis fungoides appears associated with an increase of TLR9 expression by keratinocytes in cutaneous lesions. |
| 17301562 |
Rapid progression of HIV-1 infection was associated with TLR9 polymorphisms |
| 14716310 |
mechanism of cellular activation involving the recruitment of TLR9 from the ER to sites of CpG DNA uptake, where signal transduction is initiated |
| 15153500 |
TLR signals that activate NF-kappaB are diverse among different TLRs, and TLR9 signaling uniquely depends on IRF-8 in DCs. |
| 15860583 |
a CpR dinucleotide is recognized by TLR9 and leads immune-cell activation and cytokine secretion in vitro and in vivo |
| 12734363 |
Costimulation with TLR9 (or TLR2) and TLR4 induces synergistic release of Th1 cytokines, IFN-gamma and TNF-alpha, and additive HIV-LTR trans-activation and HIV replication, as measured by p24 antigen release from HIV-1 transgenic mouse spleen cells. |
| 16230478 |
TLR9 may have a critical role in the promotion of lupus through the induction of IFN-alpha by predendritic cells. |
| 17534115 |
TLR 9 play a distinct role in the inflammatory response that clears viruses from the retina. |
| 15585868 |
TLR9 expression may function as a proinflammatory activation marker during the transition from monocyte to dendritic cells. |
| 16731773 |
we here demonstrate that S. pneumoniae, H. influenzae, and N. meningitidis each activate several TLRs in species-specific patterns and show that infection with live pathogens may lead to activation of PRR not targeted by inactivated bacteria. |
| 16849519 |
Toll-like receptor 9 (TLR9) recognizes microbial DNA. We show here that TLR9 protein is expressed in human breast cancer cells and clinical breast cancer samples. |
| 17292969 |
expression levels of TLR2, TLR3, TLR4 & TLR9 in endometrium varied in a similar pattern during the menstrual cycle; levels were high in perimenstrual period & low in periovulatory period |
| 17295441 |
Human peripheral blood B cells express TLR9 and that its expression is increased in patients with Systemic Lupus Erythematosus. |
| 17325049 |
These results demonstrate that intestinal epithelial cells recognize pathogenic bacterial DNA and respond by increasing surface localization and expression of TLR9. |
| 17469139 |
These findings suggest that tubular TLR-9 activation has a pathogenetic role in tubulointerstitial inflammation and damage in experimental and human lupus nephritis. |
