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POLB

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Symbol:	POLB
Name(s):	polymerase (DNA directed), beta
Type:	protein-coding
Organism:	Homo sapiens
Synonyms:	MGC125976
Links:	Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications
Publication Link	Summary of findings
18270339	Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
18039710	The Leu22Pro DNA polymerase beta variant has very little dRP lyase activity but retains its polymerase activity.
16195237	Observational study of gene-disease association. (HuGE Navigator)
16609022	Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17131038	Observational study of gene-disease association. (HuGE Navigator)
17203305	Observational study of gene-disease association. (HuGE Navigator)
17230526	Observational study of gene-disease association. (HuGE Navigator)
17283177	Observational study of gene-disease association. (HuGE Navigator)
17855454	Observational study of gene-disease association. (HuGE Navigator)
18006695	Observational study of gene-disease association. (HuGE Navigator)
→View more information from publications.

Interacting gene products
Interaction Type	Gene 1	Gene 2	Interaction description	Complex	Publication Link
BIND	proliferating cell nuclear antigen	polymerase, beta	Mammalian DNA beta-polymerase and PCNA can form a complex both in vitro and in vivo	-	Pubmed
HPRD	polymerase, beta	X-ray repair cross complementing protein 1	-	-	Pubmed
HPRD	polymerase, beta	X-ray repair cross complementing protein 1	-	-	Pubmed
HPRD	polymerase, beta	Josephin domain containing 3	-	-	Pubmed
BIND	polymerase, beta	nei endonuclease VIII-like 1	Pol beta interacts with Neil1.	-	Pubmed

Recent Publications on POLB:
Remarkable sequence similarity between the dinoflagellate-infecting marine girus and the terrestrial pathogen African swine fever virus. ABSTRACT: Heterocapsa circularisquama DNA virus (HcDNAV; previously...	29th October, 2009		Virol J. 2009 Oct 27;6(1):178. DOI Direct Link
A platinum agent resistance gene, POLB, is a prognostic indicator in colorectal cancer. BACKGROUND: Recent progress in chemotherapy with platinum agents has...	16th September, 2009	Department of Surgical Oncology, Medical Institute of Bioregulation,	J Surg Oncol. 2009 Sep 1;100(3):261-6. DOI Direct Link
The phytoecdysteroid profiles of 7 species of Silene (Caryophyllaceae). The phytoecdysteroid profiles of extracts of aerial parts of flowering...	15th September, 2009	Tomsk State University, Siberian Botanical Garden, 634050 Tomsk, pr.	Arch Insect Biochem Physiol. 2009 Sep 11. DOI Direct Link
polR, a pathway-specific transcriptional regulatory gene, positively controls polyoxin biosynthesis in Streptomyces cacaoi subsp. asoensis. The polyoxin (POL) biosynthetic gene cluster (pol) was recently cloned...	23rd July, 2009	State Key Laboratory of Microbial Resources, Institute of Microbiology,	Microbiology. 2009 Jun;155(Pt 6):1819-31. Epub 2009 Apr 21. DOI Direct Link
Population-specific variation in haplotype composition and heterozygosity at the POLB locus. DNA polymerase beta plays a central role in base excision repair (BER),...	21st July, 2009	Department of Genetics, Yale University School of Medicine, 333 Cedar	DNA Repair (Amst). 2009 May 1;8(5):579-84. Epub 2009 Jan 23. DOI Direct Link
→View more research publications.

Patents:
US Patent No.	Title
5041179	Method for controlling tape affixing direction of automatic tape affixing apparatus
6387376	Recombinant vaccine containing feline herpes virus type 1 particularly for treating feline infectious peritonitis
6673616	Methods and compositions for characterizing nucleic acids
6716582	Cellular arrays for the identification of altered gene expression
6783985	Gene disruption methodologies for drug target discovery
→View more patents.

POLB results (if any) from reagent suppliers

Biotin Anti-PARP Antibody - BioLegend PARP interacts with proteins in the base excision repair complex containing at least XRCC1, PARP2, POLB and LIG3. In addition PARP forms heterodimers with ... http://www.biolegend.com/biotin-anti-parp-antibody-3635.html...
DNA pol β (K-16) Antibody sc-5927 Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, POLB, 5423, 8p11.21, NM_002690 ... http://www.scbt.com/datasheet-5927-dna-pol-beta-k-16-antibod...
PARP cleaved antibody, PARP cleaved Antibody, Rabbit Polyclonal ... Subunit: Component of a base excision repair (BER) complex, containing at least XRCC1, PARP2, POLB and LIG3. Homo- and heterodimer with PARP2. ... http://www.genwaybio.com/product_info.php?products_id=197373...
DNA pol β (h): 293T Lysate sc-111735 Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, POLB, 5423, 8p11.21, P06746 ... http://www.scbt.com/datasheet-111735-dna-pol-beta-h-293t-lys...
C1231 Cholesterol cGMP, ≥98%, SyntheChol® synthetic density, 1.067 g/mL at 25 °C(lit.) Gene Information, human ... POLA1(5422), TOP2A(7153). rat ... Ar(24208), Polb(29240). storage temp. −20°C ... http://www.sigmaaldrich.com/catalog/ProductDetail.do?lang=en...
14606 Cholesterol Ph Eur density, 1.067 g/mL at 25 °C(lit.) Gene Information, human ... POLA1(5422), TOP2A(7153). rat ... Ar(24208), Polb(29240). storage temp. 2-8°C ... http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=1460...
C3045 Cholesterol powder, cell culture tested suitability, cell culture tested. Gene Information, human ... POLA1(5422), TOP2A (7153). rat ... Ar(24208), Polb(29240). storage temp. −20°C ... http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...

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POLB

Gene Information from Publications

Interacting gene products

Recent Publications on POLB:

Patents:

POLB results (if any) from reagent suppliers