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ATR


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Symbol:ATR
Name(s):ataxia telangiectasia and Rad3 related
Type:protein-coding
Organism:Homo sapiens
Synonyms:FRP1, MEC1, SCKL, SCKL1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18202016 ATR and DNA-dependent protein kinase cooperate in 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine-induced activation of the G2 checkpoint pathway
18003706 NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication fork stall and collapse.
18032786 The increase of cell membranous phosphatidylcholines containing unsaturated fatty acid residues induces phosphorylation of p53 through activation of ATR.
11393670 Observational study of gene-disease association. (HuGE Navigator)
11688760 Observational study of gene-disease association. (HuGE Navigator)
15987455 Observational study of gene-disease association. (HuGE Navigator)
16195237 Observational study of gene-disease association. (HuGE Navigator)
17879369 Observational study of gene-disease association. (HuGE Navigator)
17879369 Frequent mutations in MSI-H colon cancers were identified within the ATR damage response pathway.
17976513 This activation of ATR appeared to result from THIF-induced increases in intracellular oxidative stress, a depletion of cellular GSH and an increase in DNA strand breakage.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDataxia telangiectasia and Rad3 related proteinATMIN proteinATR interacts with ASCIZ. This interaction was modeled on a demonstrated interaction between yeast ATR and human ASCIZ.-Pubmed
HPRDataxia telangiectasia and Rad3 related proteinCHD4 protein--Pubmed
HPRDataxia telangiectasia and Rad3 related proteinCHD4 protein--Pubmed
HPRDataxia telangiectasia and Rad3 related proteinmutS homolog 2--Pubmed
HPRDataxia telangiectasia and Rad3 related proteinmutS homolog 2--Pubmed
BINDataxia telangiectasia and Rad3 related proteintumor protein p53ATR interacts with TP53 (p53).-Pubmed
BINDataxia telangiectasia and Rad3 related proteinCHK1 checkpoint homologATR interacts with CHEK1 (CHK1).-Pubmed
BINDataxia telangiectasia and Rad3 related proteinnibrin isoform 1NBS1 interacts with ATR.-Pubmed
BINDataxia telangiectasia and Rad3 related proteinpromyelocytic leukemia protein isoform 6ATR phosphorylates PML.-Pubmed
BINDataxia telangiectasia and Rad3 related proteineukaryotic translation elongation factor 1 epsilon 1p18 interacts with ATR.-Pubmed

Recent Publications on ATR:

Pubmed Logo
Neural correlates of the spacing effect in explicit verbal semantic encoding support the deficient-processing theory.
Spaced presentations of to-be-learned items during encoding leads to...
3rd November, 2009
Computational Neuroscience Laboratories, ATR, Kyoto, Japan. Hum Brain Mapp. 2009 Oct 30.
DOI Direct Link
Analytical characterization of polymers used in conservation and restoration by ATR-FTIR spectroscopy.
In the last few decades many new polymers have been synthesized that are...
3rd November, 2009
Universidad Complutense-Instituto de Patrimonio Cultural de Espana, Anal Bioanal Chem. 2009 Oct 31.
DOI Direct Link
Vascular function measured by fingertip thermal reactivity is impaired in patients with metabolic syndrome and diabetes mellitus.
Digital thermal monitoring (DTM) of vascular function has already been...
3rd November, 2009
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, J Clin Hypertens (Greenwich). 2009 Nov;11(11):678-84.
DOI Direct Link
Adsorption of sodium polyacrylate in high solids loading calcium carbonate slurries.
The adsorption of sodium polyacrylate (NaPAA) in slurries with up to...
31st October, 2009
Department of Materials Science and Engineering, University of Florida, J Colloid Interface Sci. 2009 Oct 4.
DOI Direct Link
Adsorption behavior of salicylic, benzoic, and 2-methyl-2-hexenoic acid on alumina: an in situ modulation excitation PM-IRRAS study.
Adsorption and desorption of acid molecules (10(-4) M in cyclohexane) with...
30th October, 2009
Institute for Chemical and Bioengineering, Department of Chemistry and Phys Chem Chem Phys. 2009 Nov 21;11(43):10132-9. Epub 2009 Sep 16.
DOI Direct Link

View more research publications.

Press Releases on ATR:

BioPortfolio Logo
Taxpayer Group Launches Petition to Ask Sen. Ben Nelson to Keep His Pledge 28th October, 2009 Americans for Tax Reform

Petition asks Nelson to oppose any healthcare bill with tax increases

WASHINGTON, Oct. 28 /PRNewswire-USNewswire/ -- Today, Americans for Tax Reform (ATR) continued its

BioNews Results for ATR

: RSS Logo
BioPortfolio Logo
DIARY - US Company Meetings for Thursday Nov 12, 2009
Reuters:  Nov 12 2009 10:05AM Matching: atr
ATR releases an online petition to oppose Senate healthcare bill
News-Medical.Net:  Oct 29 2009 9:31AM Matching: atr
New Oral Anticoagulant Rivals Warfarin in Atr
Pharmacy Practice News:  Oct 28 2009 4:34PM Matching: atr
Research study provides supportive evidence for using ATR inhibitors in cancer therapy
News-Medical.Net:  Oct 19 2009 6:51AM Matching: atr
Loss of tumor-suppressor and DNA-maintenance proteins causes tissue demise
EurekAlert!:  Oct 19 2009 7:17AM Matching: atr
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Clinical Trials:

Clinical Trials Logo
ONCE - Only Nocturnal Combination Evaluation of Antiretroviral-Experienced HIV 1 Infected Subjects Switching to Atripla

Patents:

Patents logo
US Patent No.Title
7595890 Porous microsphere resonators
7601351 Antibodies against protective antigen
7601421 Fabrication of carbon nanotube reinforced epoxy polymer composites using functionalized carbon nanotubes
7601459 Fuel cell system
7601710 Preparation of hymenialdisine derivatives and use thereof

View more patents.

ATR results (if any) from reagent suppliers

Google CSE Logo
ATR Antibody #2790
Immunoprecipitation of ATR from HeLa cell lysates using ATR Antibody. Western blot detection was performed using the same antibody. ...
http://www.cellsignal.com/products/2790.html...

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ATR antibody (ab10312) | Abcam
Rabbit polyclonal to ATR. Ataxia Telangiectasia Mutated (ATM) and Rad 3-related protein (ATR) is a phosphatidylinositol kinase (PK)-related kinase which ...
http://www.abcam.com/ATR-antibody-ab10312.html...

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Phospho-ATR (Ser428) Antibody #2853
Polyclonal antibodies are prepared by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to residues surrounding Ser428 of human ATR.
...
http://www.cellsignal.com/products/2853.html...

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The Abcam catalog
ATR antibodies. ... ATR antibody. WB. Rabbit polyclonal. Reacts with: Hu, Ms, Cow, Hm. ab10946 · ATR antibody. WB. Rabbit polyclonal. Reacts with: ...
http://www.abcam.com/index.html?t=159&pt=1&c=886...

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ATR Antibody / ATR Antibodies
ATR Antibody / ATR Antibodies. ... ATR specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-atr.html...

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Phospho-(Ser/Thr) ATM/ATR Substrate Antibody #2851
Ataxia telangiectasia mutated kinase (ATM) and ataxia telangiectasia and Rad3- related kinase (ATR) are related kinases that regulate cell cycle checkpoints
...
http://www.cellsignal.com/products/2851.html...

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ATR Antibody (IN) Anthrax receptor
ATR antibody can be used for detection of ATR by Western blot at 0.5 to 1 ug/ml. It is human, mouse, and rat reactive. It will recognize all three isoforms. ...
http://www.prosci-inc.com/shop/catalog1/ATR-Antibody-p-6161....

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