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MED1
| Symbol: | MED1 | | Name(s): | mediator complex subunit 1 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | CRSP1, CRSP200, DRIP205, DRIP230, MGC71488, PBP, PPARBP, PPARGBP, RB18A, TRAP220, TRIP2 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 15095040 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17117180 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12037571 |
MED1/TRAP220 is the nuclear receptor-interacting subunit of the Mediator complex and is required for PPARgamma-stimulated adipogenesis. |
| 17641689 |
Recruitment of CBP and TRAP220 was diminished by the overexpression of a MED25 NR box deletion mutant, and by treatment with MED25 siRNA |
| 15848166 |
RB18A plays a central role to control p53wt and p53mut protein content and functions in cells through a loop of regulation, which involves MDM2 |
| 15187081 |
DRIP205 has a role as a coactivator of FXR |
| 16239257 |
MED14 and MED1 are used by glucocorticoid receptor in a gene-specific manner, providing a mechanism for promoter selectivity by glucocorticoid receptor |
| 12130544 |
TFIID and human mediator coactivator (TRAP220) complexes assemble cooperatively on promoter DNA |
| 11840331 |
regulates p53-dependent apoptosis |
| 16314496 |
ERK-mediated phosphorylation is a regulatory mechanism that controls TRAP220/Med1 expression levels and modulates its functional activity. | →View more information from publications. |
Recent Publications on MED1: |  |
Regulation of the hyaluronan synthase 2 gene by convergence in cyclic AMP response element-binding protein and retinoid acid receptor signaling.
The human hyaluronan synthase 2 (HAS2) gene encodes for an enzyme making... | 29th October, 2009
| Department of Bioscience, of Kuopio, FIN-70211 Kuopio, Finland.
| J Biol Chem. 2009 Jul 3;284(27):18270-81. Epub 2009 May 5.
DOI Direct Link |
PBP is essential for the growth of active Notch4-immortalized mammary epithelial cells by activating SOX10 expression.
PBP (Peroxisome proliferator-activated receptor Binding Protein)... | 27th October, 2009
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| Biochem J. 2009 Oct 26.
DOI Direct Link |
Dynamic interactions and cooperative functions of PGC-1alpha and MED1 in TRalpha-mediated activation of the brown-fat-specific UCP-1 gene.
PGC-1alpha is an inducible nuclear receptor coactivator with direct... | 9th October, 2009
| Laboratory of Biochemistry and Molecular Biology, The Rockefeller
| Mol Cell. 2009 Sep 24;35(6):755-68.
DOI Direct Link |
Concomitant therapy with Cineole (Eucalyptole) reduces exacerbations in COPD: a placebo-controlled double-blind trial.
BACKGROUND: The clinical effects of mucolytics in patients with chronic... | 17th September, 2009
| Hospital Furth, University Erlangen-Nurnberg, D-90766 Furth, Germany.
| Respir Res. 2009 Jul 22;10:69.
DOI Direct Link |
The mediator complex subunit 1 enhances transcription of genes needed for adrenal androgen production.
There are three enzymes involved in the biosynthesis of the adrenal... | 17th September, 2009
| Department of Physiology, University of Veterinary Medicine, 30173
| Endocrinology. 2009 Sep;150(9):4145-53. Epub 2009 Jun 4.
DOI Direct Link |
→View more research publications. |
MED1 results (if any) from reagent suppliers | 
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TRAP220/MED1 (phospho T1457) antibody - ChIP Grade (ab60950) | Abcam
Rabbit polyclonal to TRAP220/MED1 (phospho T1457) - ChIP Grade. TRAP220/MED1 work with coactivators to direct transcriptional initiation by the RNA ...
http://www.abcam.com/TRAP220-MED1-phospho-T1457-antibody-ChI...
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BioVendor R&D - Antibodies \ Leptin Human, Mouse Monoclonal ...
Nature Med. 1, 1155-1161 (1995) . Lonnqvist F., Arner P., Nordfors L. and ... Nature Med. 1, 950-953 (1995) . Zhang Y., Proenca R., Maffei M., Barone M., ...
http://www.biovendor.com/product/antibodies/leptin-human-mou...
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TRAP220/MED1 antibodies: Chromatin and Nuclear Signaling ...
TRAP220/MED1 antibodies. ... TRAP220/MED1 (phospho T1457) antibody - ChIP Grade ... TRAP220/MED1 antibody. IP, WB. Rabbit polyclonal ...
http://www.abcam.com/index.html?t=127063&pt=1&c=3390&ei=&mu=...
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Anti-Amyloid Peptide b, Cleavage Site 43 antibody produced in ...
Alzheimer's disease., Neuromolecular Med., 1, 1-31. (2002). 4. Soreghan, B., et al. ... Neuromolecular Med., 1,81-94 (2002). 5. Savage, M.J., et al. ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...
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TRAP220/MED1 antibodies: Cell Biology > Apoptosis > Intracellular ...
TRAP220/MED1 antibodies. ... Applications (see key) & Reactivity (see key). Image Abreview Publication. ab22229 · TRAP220/MED1 antibody ...
http://www.abcam.com/index.html?t=127063&pt=1&c=302&ei=&mu=r...
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TRAP220 (M-255) Antibody sc-8998
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, MED1, 5469, 17q12, NM_004774 ...
http://www.scbt.com/datasheet-8998-trap220-m-255-antibody.ht...
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mouse/human Granzyme B antibody, Cytokine Kits conjugate
Med. 1: 14. Rininsland F, et al. 2000. Granzyme B ELISPOT assay for ex vivo measurements of T cell immunity. J. Immunol. Meth. 240:143-155. ...
http://www.ebioscience.com/ebioscience/specs/antibody_88/88-...
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