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XAF1


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Symbol:XAF1
Name(s):XIAP associated factor 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:BIRC4BP, HSXIAPAF1, XIAPAF1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17613533 XAF1 mediates Survivin down-regulation through a complex containing XIAP, supporting dual roles for XAF1 in apoptosis
17449173 Low XAF1 mRNA expression levels relate to an unfavorable clinical course in renal cell carcinoma.
17087954 Down-regulation of XAF1 in association with hypermethylation was detected in 3 of 4 human gastric cancer cell lines and 6 of 8 colon cancer cell lines.
12029096 XAF1 augments TRAIL-induced apoptosis
16909101 Epigenetic alteration of XAF1 is frequent in human urogenital cancers and may contribute to the malignant progression of tumors by rendering tumor cells a survival advantage partially through the attenuated p53 response.
14612497 Epigenetic silencing of XAF1 by aberrant promoter methylation may contribute to the malignant progression of human gastric tumors.
16353137 alternative splicing of XAF1 mRNA leads to formation of truncated XAF1 protein, which likely affects its functional interaction with XIAP, and consequently, contributes to pathogenesis of prostate cancers by disrupting balance of apoptosis machinery
15610524 XAF1 expression in melanoma tissues was significantly reduced compared with benign melanocytic nevi
17376236 Our study provides evidence that XAF1 is a crucial interferon-stimulated gene (ISG) mediator of IFN-induced sensitization to TRAIL in cancer.
17570219 Genetic and epigenetic alteration of XAF1 is a common event in colorectal tumorigenesis and contributes to the malignant tumor progression by providing survival advantages for tumor cells under various stress conditions.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDbaculoviral IAP repeat-containing protein 4XIAP associated factor-1--Pubmed
HPRDbaculoviral IAP repeat-containing protein 4XIAP associated factor-1--Pubmed
HPRDbaculoviral IAP repeat-containing protein 4XIAP associated factor 1 isoform 1--Pubmed

Patents:

Patents logo
US Patent No.Title
7384911 Peptides having antimicrobial properties and compositions containing them, notably for the preservation of foodstuffs
7345081 Azabicyclo-octane inhibitors of IAP
7081340 Gene expression profiling in biopsied tumor tissues
6946544 XAF genes and polypeptides: methods and reagents for modulating apoptosis
5982680 Semiconductor memory

View more patents.

XAF1 results (if any) from reagent suppliers

Google CSE Logo
XAF1 antibody (ab17204) | Abcam
Rabbit polyclonal to XAF1. XAF1 binds to XIAP, an inhibitor of caspases-3, -7, and -9, and triggers its relocation from the cytosol to the nucleus.
http://www.abcam.com/XAF1-antibody-ab17204.html...

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XAF1 (C-16) Antibody sc-19194
See how others have used XAF1 (C-16): sc-19194 antibody and or XAF1 (C-16) antibody ... HSF1 Down-regulates XAF1 through Transcriptional Regulation. ...
http://www.scbt.com/datasheet-19194-xaf1-c-16-antibody.html...

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Polyclonal Antibody to XAF1 (XIAP Associated Factor 1)
Xaf1 can cooperate with TNFá in the induction of apoptosis, independently of interaction with XIAP. Yan Xia, Rachel Novak, Jennifer Lewis, Colin S. Duckett,
...
http://www.imgenex.com/tds/IMG-379.pdf...

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XAF1 (L-16) Antibody sc-19193
See how others have used XAF1 (L-16): sc-19193 antibody and or XAF1 (L-16) ... Western blot analysis of XAF1 expression in non-transfected: sc-117752 (A) ...
http://www.scbt.com/datasheet-19193-xaf1-l-16-antibody.html...

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XAF1 proteins and peptides: Cell Biology > Apoptosis ...
XAF1 proteins and peptides. ... XAF1 peptide (305-317). BL, WB. Terms and conditions · Legal · Privacy policy · Investor relations · Contact us · Blog ...
http://www.abcam.com/index.html?t=108007&pt=2&c=1045&ei=&mu=...

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XAF1 siRNA (m) sc-155371
Click here for details. suitable control antibody: contact Technical Service for availability of control antibody; sqRT-PCR Primer also available: XAF1 ...
http://www.scbt.com/ko/datasheet-155371-xaf1-sirna-m.html...

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OMI Antibody IAP inhibitor
The activity of these proteins can be modulated by the expression of proteins such as Smac/DIABLO and XAF-1 which displace or prevent the binding of ...
http://www.prosci-inc.com/shop/catalog1/OMI-Antibody-p-6209....

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