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FANCL


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Gene DB Home
Symbol:FANCL
Name(s):Fanconi anemia, complementation group L
Type:protein-coding
Organism:Homo sapiens
Synonyms:FAAP43, FLJ10335, PHF9, POG
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18270339 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
12973351 data suggest that PHF9 has a crucial role in the Fanconi anemia pathway as the likely catalytic subunit required for monoubiquitination of FANCD2
16474167 FANCL, via its WD40 region, binds the FA complex and, via its PHD, recruits an as-yet-unidentified E2 for mono-ubiquitination of FANCD2
17106252 Abnormal FANCL expression is the cause leading to a defective Ranconi anemia-BRCA pathway, conferring sensitivity of a lung cancer cell line to mitomycin C>
12606378 FANCL is necessary for primordial germ cell proliferation during the embryonic stage but not necessary for spermatogonia proliferation in adulthood. Thus, mouse FancL-/- males are infertile at 7 to 12 weeks but gain fertility thereafter.
12417526 Deficiency of Fancl (also called Pog) is the cause of gcd mouse, which has a reduced number of primordial germ cells during the embryonic stage.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDPHD finger protein 9gametogenetin--Pubmed

Patents:

Patents logo
US Patent No.Title
7592298 Composition for oil-based liquid cleansing
6630193 Germinated brown rice
6116445 Sealing cap for containers

FANCL results (if any) from reagent suppliers

Google CSE Logo
FANCL antibody (ab42639) | Abcam
Rabbit polyclonal to FANCL. FANCL is a ubiquitin ligase protein that mediates ubiquitination of FANCD2, a key step in the DNA damage pathway. ...
http://www.abcam.com/FANCL-antibody-ab42639.html...

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FANCL (H-197) Antibody sc-66887
FANCL siRNA shRNA (h) Lentiviral Particles, sc-45661-V, 200 µl ... Western blot analysis of FANCL expression in non-transfected 293T: sc-117752 (A), ...
http://www.scbt.com/datasheet-66887-fancl-h-197-antibody.htm...

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FANCL antibodies: Chromatin and Nuclear Signaling > DNA / RNA ...
FANCL antibodies. ... Applications (see key) & Reactivity (see key). Image Abreview Publication. ab42639 · FANCL antibody. Fast Track ...
http://www.abcam.com/index.html?t=126530&pt=1&c=880&ei=&mu=r...

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FANC Antibody / FANC Antibodies
FANCL (B-11) Antibody, sc-137067, mouse IgG2b, 76-375 (h), WB, IP, IF, ... FANCL (K-12) Antibody, sc-46114, goat IgG, internal (h), WB, IF, ELISA, m, r, h ...
http://www.scbt.com/table-fanc.html...

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FANCL proteins and peptides: Chromatin and Nuclear Signaling > DNA ...
FANCL proteins and peptides. ... FANCL proteins and peptides. Code. Name. Applications (see key) & Reactivity (see key). Image Abreview Publication ...
http://www.abcam.com/index.html?t=126530&pt=2&c=880&ei=&mu=r...

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FANCL (h): 293T Lysate sc-116313
FANCL (H-300): sc-66887. Western blot analysis of FANCL expression in non- transfected: sc-117752 (A) and human FANCL transfected: sc-116313 (B) 293T whole
...
http://www.scbt.com/datasheet-116313-fancl-h-293t-lysate.htm...

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Page 1 of 2 e-mail: info@rockland-inc.com Visit our website at ...
FANCF, FANCG, FANCL/PHF9 and FANCM. FANCG contains a. 5-prime GC-rich untranslated region characteristic of housekeeping genes. The putative 622-amino
acid ...
http://www.rockland-inc.com/objects/catalog/product/extras/1...

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