|
| |
PRG2
| Symbol: | PRG2 | | Name(s): | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | BMPG, MBP, MBP1, MGC14537 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
|
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 16940047 |
two regions shown previously to contain the cytotoxic and cytostimulatory properties of MBP are accessible for ligand interaction in cell surface-bound MBP |
| 15647258 |
the proform of eosinophil major basic protein inhibits the proteolytic activity of PAPP-A |
| 12534990 |
Deposits of eosinophilic MBP are found on the surface of eosinophils and damaged muscle fibers surrounded by eosinophils in patients with idiopathic eosinophilic myositis. |
| 12202480 |
Transcription is regulated by novel combinatorial interactions of GATA-1, PU.1, and C/EBPepsilon isoforms. |
| 17082653 |
Compared to MBP1, which is present in eosinophils, basophils, and a human mast cell line, homologous MBP2 is present only in eosinophils and may be a useful biomarker for eosinophil-associated diseases. |
| 14988014 |
Proform of MPB forms a covalent complex with PAPPA in which PAPPA is inhibited. |
| 14500673 |
MBP stimulates a Src kinase-dependent activation of class I(A) phosphoinositide 3-kinase and, in turn, activation of protein kinase C zeta in neutrophils, which contributes to the activation of NADPH oxidase and resultant superoxide production. |
| 12370176 |
IGF bioactivity is regulated by reversible cell surface binding of PAPP-A, which in turn is regulated by proMBP |
| 12421832 |
MBP's structure is described, and its ability to bind to pregnancy-associated plasma protein A explained |
Recent Publications on PRG2: |  |
Subcellular fractionation of human eosinophils: isolation of functional specific granules on isoosmotic density gradients.
Subcellular fractionation has been an important tool in investigating... | 16th May, 2009
| Department of Medicine, Harvard Medical School, Beth Israel Deaconess
| J Immunol Methods. 2009 May 15;344(1):64-72. Epub 2009 Mar 26.
DOI Direct Link |
[Expression of eosinophil major basic protein mRNA in bronchial asthma]
OBJECTIVE: To investigate the expression of eosinophil major basic protein... | 31st May, 2008
| Department of Respiratory Diseases, Nanfang Hospital, Southern Medical
| Nan Fang Yi Ke Da Xue Xue Bao. 2006 Sep;26(9):1330-3.
|
Human eosinophil major basic protein 2: location of disulfide bonds and free sulfhydryl groups.
Eosinophil granule major basic protein 2 (MBP2 or major basic protein... | 12th October, 2007
| Department of Dermatology, School of Medicine, University of Utah, Room
| Protein J. 2007 Jan;26(1):13-8.
DOI Direct Link |
Major basic protein homolog (MBP2): a specific human eosinophil marker.
Human eosinophil granule major basic protein (MBP1) is an exceedingly... | 6th January, 2007
| Allergic Diseases Research Laboratory, Mayo Clinic and Foundation,
| J Immunol. 2006 Nov 15;177(10):7340-5.
|
siRNA-mediated AML1/MTG8 depletion affects differentiation and proliferation-associated gene expression in t(8;21)-positive cell lines and primary AML blasts.
The chromosomal translocation t(8;21) is associated with 10-15% of all... | 7th November, 2006
| Cancer Research UK Medical Oncology Laboratory, Barts and the London
| Oncogene. 2006 Oct 5;25(45):6067-78. Epub 2006 May 1.
DOI Direct Link |
→View more research publications. |
PRG2 results (if any) from reagent suppliers | 
|
PRG2 antibody [BMK-13] (ab48372) | Abcam
Mouse monoclonal [BMK-13] to PRG2. PRG2 is a cytotoxin and helminthotoxin. It also induces noncytolytic histamine release from human basophils and is ...
http://www.abcam.com/PRG2-antibody-BMK-13-ab48372.html...
|
 |
EMBP (1.B.787) Antibody sc-59163
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, PRG2, 5553, 11q12.1, NM_002728 ...
http://www.scbt.com/datasheet-59163-embp-1-b-787-antibody.ht...
|
 |
PRG2 antibodies: Immunology > Cell Type Markers > CD > NK Cells ...
PRG2 antibodies. ... PRG2 antibody [1.B.787] - Azide free. IHC-P. Mouse monoclonal ... PRG2 antibody [2Q2176]. IHC-P, WB, IHC-Fr. Mouse monoclonal ...
http://www.abcam.com/index.html?t=77517&pt=1&c=503&ei=&mu=ra...
|
 |
EMBP (M-223) Antibody sc-33557
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Mouse, Prg2, 19074, 2 D, Q61878 ...
http://www.scbt.com/datasheet-33557-embp-m-223-antibody.html...
|
 |
PAPPA protein, PAPP-A Fragment: Human, Recombinant, E Coli ...
Enzyme Regulation: Inhibited by complexation with the proform of PRG2. Subunit: Homodimer; disulfide-linked. In pregnancy serum, predominantly found as a ...
http://www.genwaybio.com/product_info.php?products_id=288126...
|
 |
Abcam antibodies and reagents product map
... OVGP1 antibodies (1) · P protein antibodies (1) · PATE antibodies (1) · PLEKHH2 antibodies (1) · PPHLN1 antibodies (1) · PRG2 antibodies (2) ...
http://www.abcam.com/index.html?cl=251&pageconfig=productmap...
|
 |
Mbp antibody, MAb Oligodendrocytes & Myelin Antibody, Mouse ...
PRG2 [1.B.787], IgG Native_Protein. ALPHA 1 MICROGLOBULIN, Native_Protein · UTI Human, Native_Protein · MYELIN, Native_Protein · Non-Neuronal Enolase (NNE), ...
http://www.genwaybio.com/product_info.php?products_id=240133...
|
 |
Search Bioportfolio and other Life Science Sites for PRG2,
or search for PRG2 on BioPortfolio's antibody search engine.
This page has been viewed 94 times
Recent Search Terms used to find this page: piezoelectricity proteoglycan | PRG eosinophil | .
Resources from the NCBI used on this page, NCBI's standard disclaimer applies.
|
