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CHFR


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Gene DB Home
Symbol:CHFR
Name(s):checkpoint with forkhead and ring finger domains
Type:protein-coding
Organism:Homo sapiens
Synonyms:FLJ10796, FLJ33629, RNF116, RNF196
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18079053 Observational study of gene-disease association. (HuGE Navigator)
18172500 interaction of poly(ADP-ribose) with a PBZ motif in two representative human proteins, APLF (aprataxin PNK-like factor) and CHFR (checkpoint protein with FHA and RING domains)
17673375 CHFR gene is neither mutated nor hypermethylated in ovarian cancer
17786301 Epigenetic inactivation of the CHFR gene in cervical cancer contributes to sensitivity to taxanes
15302856 CHFR has a role in blocking mitosis along with p38 MAP kinase
17201143 CHFR might act as a tumor suppressor in at least some colorectal cancers and that CHFR methylation might, therefore, be a particular phenomenon of early colorectal cancer
17596595 CHFR has a role as a tumor suppressor in breast cancer
15674323 We conclude that the mechanism by which CHFR delays chromosome condensation involves inhibition of accumulation of Cyclin B1 in the nucleus.
12810945 CHFR has a role in mitotic checkpoint control
12538348 Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDPMLHomo sapiens cell cycle checkpoint protein CHFR mRNA, complete cds.--Pubmed
BIND-checkpoint with forkhead and ring finger domainsCHFR interacts an unspecified isoform of PML.-Pubmed
HPRDpromyelocytic leukemia protein isoform 1Checkpoint protein with FHA and ring finger domains--Pubmed
BINDserine/threonine protein kinase 6E3 ubiquitin-protein ligase CHFR.STK6 (Aurora A) interacts with CHFR.-Pubmed
HPRDHomo sapiens cell cycle checkpoint protein CHFR mRNA, complete cds.Homo sapiens cell cycle checkpoint protein CHFR mRNA, complete cds.--Pubmed

Clinical Trials:

Clinical Trials Logo
Phase I/II of Oral Vorinostat Combination With Erlotinib in NSCLC Patients With EGFR Mutations With DP After Erlotinib.

Patents:

Patents logo
US Patent No.Title
7547767 Growth arrest specific gene 6 peptides, antibodies, compositions, methods and uses
5302196 Modified cellulose ethers and the use thereof in dispersion paints
6765387 System and method for measuring resistivity through casing
6894500 Method and apparatus for determining the resistivity of a formation surrounding a cased well
6979557 Full-length cDNA

View more patents.

CHFR results (if any) from reagent suppliers

Google CSE Logo
CHFR antibody (ab4184) | Abcam
Rabbit polyclonal to CHFR. A number of human cancers are sensitive to mitotic stress, implying checkpoint defects. Many proteins that contain ...
http://www.abcam.com/CHFR-antibody-ab4184.html...

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Chfr Antibody / Chfr Antibodies
Chfr Antibody / Chfr Antibodies. ... Chfr specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-chfr.html...

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CHFR antibodies: Cancer > Cell cycle > Cell cycle inhibitors ...
CHFR antibodies. ... CHFR antibody. IHC-P, ELISA. Images. Goat polyclonal. Reacts with: Hu. Predicted: Ms, Rat. ab57638 · CHFR antibody. IHC-P, WB ...
http://www.abcam.com/index.html?t=14775&pt=1&c=4205&ei=&mu=r...

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Chfr (L2) Antibody sc-81832
mouse monoclonal IgG1, 100 µg/ml; raised against recombinant Chfr of human origin ... Chfr (L2): sc-81832. Immunoperoxidase staining of formalin-fixed, ...
http://www.scbt.com/datasheet-81832-chfr-l2-antibody.html...

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CHFR proteins and peptides: Chromatin and Nuclear Signaling > Cell ...
CHFR proteins and peptides. ... Applications (see key) & Reactivity (see key). Image Abreview Publication. ab24681 · CHFR peptide ...
http://www.abcam.com/index.html?t=14775&pt=2&c=3464&ei=&mu=r...

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Chfr (D-15) Antibody sc-13288
See how others have used Chfr (D-15): sc-13288 antibody and or Chfr (D-15) ... CHFR, a potential tumor suppressor, downregulates interleukin-8 through the ...
http://www.scbt.com/datasheet-13288-chfr-d-15-antibody.html...

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All Cell Cycle Inhibitors | Abcam
CHFR antibody. IHC-P, ELISA. Images. Goat polyclonal. Reacts with: ... CHFR antibody. WB, ELISA. Images. Rabbit polyclonal. Reacts with: Hu, Ms, Rat ...
http://www.abcam.com/index.html?c=3461...

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