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PRKD1


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Symbol:PRKD1
Name(s):protein kinase D1
Type:protein-coding
Organism:Homo sapiens
Synonyms:PKC-MU, PKCM, PKD, PRKCM
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18239146 review: novel functions for PKD-mediated pathways in the heart and the circulation.
17703233 these findings establish a major role for DAPk and its specific interaction with PKD in regulating the JNK signaling network under oxidative stress.
17804414 Data suggest that PKD1 phosphorylation at Tyr95 generates a binding motif for PKCdelta, and that oxidative stress-mediated PKCdelta/PKD interaction results in PKD1 activation loop phosphorylation and activation.
17635916 PKD is a physiologically relevant enzyme for SPHK2 phosphorylation, which leads to its nuclear export for subsequent cellular signaling.
17591919 Regulation of secretory transport by PKD-mediated phosphorylation of CERT is reported.
12778467 PKCmu activation is associated with a unique signaling pathway coupling TCR ligation with T cell proliferation.
11903052 Involvement of protein kinase D in Fc gamma-receptor activation of the NADPH oxidase in neutrophils
16166634 Protein kinase D-mediated MnSOD expression promotes increased survival of cells upon release of mitochondrial reactive oxygen species
17389598 PKD1 stimulates GAL4-CREB-mediated transcription in a Ser-133-dependent manner, activates CRE-responsive promoters
12393506 study shows that PKD is rapidly activated by a wide variety of platelet agonists through a PKC-dependent pathway; activation of PKD enables phosphorylation of a distinct set of substrates to those targeted by PKC in platelets

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDBruton agammaglobulinemia tyrosine kinaseprotein kinase D1--Pubmed
HPRDBruton agammaglobulinemia tyrosine kinaseprotein kinase D1--Pubmed
HPRDcomplement component 1, q subcomponent binding protein precursorprotein kinase D1--Pubmed
HPRDcomplement component 1, q subcomponent binding protein precursorprotein kinase D1--Pubmed
BINDinsulin-like growth factor 1 receptor precursorprotein kinase D1PKC-mu interacts with IGF-IR.-Pubmed
HPRDjun oncogeneprotein kinase D1--Pubmed
HPRDjun oncogeneprotein kinase D1--Pubmed
HPRDmetallothionein 2Aprotein kinase D1--Pubmed
HPRDPhospholipase C, gamma 1protein kinase D1--Pubmed
HPRDphospholipase C gamma 1 isoform aProtein kinase C, mu--Pubmed

Recent Publications on PRKD1:

Pubmed Logo
A 3 Mb deletion in 14q12 causes severe mental retardation, mild facial dysmorphisms and Rett-like features.
The present report describes a 7-year-old girl with a de novo 3 Mb...
20th August, 2008
Medical Genetics Molecular Biology Department, University of Siena, Siena, Am J Med Genet A. 2008 Aug 1;146A(15):1994-8.
DOI Direct Link

Patents:

Patents logo
US Patent No.Title
7612181 Dual variable domain immunoglobulin and uses thereof
7601852 Macrocyclic kinase inhibitors

PRKD1 results (if any) from reagent suppliers

Google CSE Logo
p-PKC μ (Ser 738) Antibody sc-101781
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, PRKD1, 5587, 14q12, NM_002742 ...
http://www.scbt.com/datasheet-101781-p-pkc-mu-ser-738-antibo...

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Protein Kinase D (PKD)
P3987, Anti-Protein Kinase D antibody produced in rabbit, IgG fraction of antiserum, human ... PRKD1(5587), human, mouse, ARR, IP, WB, pricing ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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PKC μ (A-20) Antibody sc-638
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Mouse, Prkd1, 18760, 12 B3, Q62101 ...
http://www.scbt.com/datasheet-638-pkc-mu-a-20-antibody.html...

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IS EASY
PKC-mu (PKD-1, PRKD1). ULight-CREBtide (10.2). ULight-PLK (8.4). ULight-PKC (5.6 ) ... PKD1 (PRKD1, PKC-mu). ULight-PLK (14.4). ULight-CREBtide (6.0) ...
http://las.perkinelmer.com/content/Manuals/GDE_LANCEUltraSer...

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PKC ν (L-20) Antibody sc-33408
Mouse, Prkd1, 18760, 12 B3, NM_029239 · Q62101, N/A. Mouse, Prkd3, 75292, 17 E3, Q8K1Y2, N/A. Ordering Information. Product Name, Catalog #, Unit, Price ...
http://www.scbt.com/datasheet-33408-pkc-nu-l-20-antibody.htm...

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LanthaScreen® Eu Kinase Binding Assay Validation Table
PRKD1, PV3791 · Eu-anti-GST · kinase tracer 236, 30 nM. PRKD2, PV3758 · Eu-anti- GST · kinase tracer 236, 100 nM. PRKG1, PV4340 · Eu-anti-GST · kinase tracer ...
http://www.invitrogen.com/site/us/en/home/Products-and-Servi...

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Mitogen Activated Protein Kinase (MAPK)
MAP2K7 · MUSK · PRKCQ (PKCτ), TYMP (ECGF1). MAP3K1 · PAK1 · PRKCZ (PKCζ), TYRO3 (SYK). MAP3K2 · PAK2 · PRKD1 (PKCμ), VCL · MAP3K3 · PAK3 · PRKD3 (PKCν) ...
http://www.invitrogen.com/site/us/en/home/Products-and-Servi...

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