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PRKDC
| Symbol: | PRKDC | | Name(s): | protein kinase, DNA-activated, catalytic polypeptide | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 12750264 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15313891 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16510122 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17196815 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17389609 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17764108 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 18158334 |
Histone mRNA stability may be directly controlled by ATR/ATM- and DNA-PK-mediated phosphorylation of UPF1. |
| 18172300 |
Taken together, these results show a DNA-PK-dependent component to the IR-induced G(2) checkpoint, in addition to the well-defined ATM-dependent component. |
| 17963495 |
DNA Ligase IV/XRCC4 recruitment by DNA-PK to DNA double-strand breaks prevents the formation of long ssDNA ends at double-strand breaks during the S phase. |
| 17932067 |
There is some sequence-dependent variation in the efficiency and position of hairpin opening by Artemis:DNA-PKcs; providing more clarity on the extent to which the hairpin opening position contributes to junctional diversity in V(D)J recombination. | →View more information from publications. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | ABL | protein kinase, DNA-activated, catalytic polypeptide isoform 1 | - | - | Pubmed |
| HPRD | v-abl Abelson murine leukemia viral oncogene homolog 1 isoform a | DNA dependent protein kinase catalytic subunit | - | - | Pubmed |
| HPRD | ADP ribosyl transferase | protein kinase, DNA-activated, catalytic polypeptide isoform 1 | - | - | Pubmed |
| BIND | serine/threonine protein kinase | protein kinase, DNA-activated, catalytic polypeptide isoform 1 | DNA-PKcs interacts with Akt1. | - | Pubmed |
| HPRD | ATM | protein kinase, DNA-activated, catalytic polypeptide isoform 1 | - | - | Pubmed |
| HPRD | ataxia telangiectasia mutated protein isoform 1 | DNA dependent protein kinase catalytic subunit | - | - | Pubmed |
| HPRD | IKK alpha | protein kinase, DNA-activated, catalytic polypeptide isoform 1 | - | - | Pubmed |
| HPRD | conserved helix-loop-helix ubiquitous kinase | DNA dependent protein kinase catalytic subunit | - | - | Pubmed |
| HPRD | Ku70 | protein kinase, DNA-activated, catalytic polypeptide isoform 1 | - | - | Pubmed |
| HPRD | ATP-dependent DNA helicase II, 70 kDa subunit | DNA dependent protein kinase catalytic subunit | - | - | Pubmed |
Recent Publications on PRKDC: |  |
DNA-PKcs deficiency in human: long predicted, finally found.
PURPOSE OF REVIEW: To describe new immunological and molecular findings of... | 14th October, 2009
| Department of Immunology, Erasmus MC,, Rotterdam, The Netherlands.
| Curr Opin Allergy Clin Immunol. 2009 Dec;9(6):503-9.
DOI Direct Link |
Systemic correction of storage disease in MPS I NOD/SCID mice using the sleeping beauty transposon system.
The Sleeping Beauty (SB) transposon system is a nonviral vector that... | 14th October, 2009
| Department of Genetics, Cell Biology and Development, Center for Genome
| Mol Ther. 2009 Jul;17(7):1136-44. Epub 2009 Apr 21.
DOI Direct Link |
Radioresistant cervical cancer shows upregulation of the NHEJ proteins DNA-PKcs, Ku70 and Ku86.
BACKGROUND: Radiotherapy is central in the treatment of cervical cancer.... | 19th September, 2009
| Department of Gynaecologic Oncology, Radiumhemmet, Karolinska University
| Br J Cancer. 2009 Sep 1;101(5):816-21. Epub 2009 Aug 11.
DOI Direct Link |
Adeno-associated virus and adenovirus coinfection induces a cellular DNA damage and repair response via redundant phosphatidylinositol 3-like kinase pathways.
During adeno-associated virus and adenovirus (AAV/Ad) coinfection,... | 18th September, 2009
| Department of Biochemistry and Cancer Biology, University of Toledo,
| Virology. 2009 Sep 15;392(1):24-33. Epub 2009 Jul 23.
DOI Direct Link |
Significance of phosphatase and tensin homologue (PTEN), O(6)-methylguanine-DNA methyltransferase (MGMT), and DNA-dependent protein kinase catalytic subunit (DNA-PKcs) protein expression in gynaecomastia.
This study was designed to investigate the pathogenesis of gynaecomastia... | 18th September, 2009
| Department of Aesthetic and Plastic Surgery, The Second Hospital of
| J Int Med Res. 2009 May-Jun;37(3):641-9.
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→View more research publications. |
PRKDC results (if any) from reagent suppliers | 
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PRKDC Antibody
Specific antibody for the gene product of PRKDC, the protein Protein kinase DNA- activated, catalytic. Validated for specificity by gene-silencing with siRNA ...
http://www.piercenet.com/Products/browse.cfm?fldID=C7219480-...
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DNA-Dependent Protein Kinase (DNA-PK)
P9870, Anti-PRKDC antibody produced in rabbit, (polyclonal), affinity isolated antibody ... human ... PRKDC(5591), human, IF (i), IHC (p), IP, WB, pricing ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...
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DNA-PK antibody, DNA PKcs (Ab-2609) Antibody, Rabbit Polyclonal ...
Subunit: DNA-PK is a heterotrimer of PRKDC and the Ku p70-p86 (XRCC6-XRCC5) dimer. ... MCM4 and PRKDC, human genes encoding proteins MCM4 and DNA-PKcs, ...
http://www.genwaybio.com/product_info.php?products_id=210107...
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DNA-PKCS (C-19) Antibody sc-1552
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, PRKDC, 5591, 8q11.21, NM_006904 ...
http://www.scbt.com/datasheet-1552-dna-pkcs-c-19-antibody.ht...
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Search Results
Cg-Prkdc Tg(TcrLCMV)327Sdz/Dvs JAX® Mice Database ... Cg-Prkdc H2- Ab1 Tg(HLA-DQA1,HLA-DQB1)1Dv/SzJ JAX® Mice Database ...
http://www.jax.org/search/Main.jsp?sg=4&qt=preclinical&page=...
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Abgent - Chromatin and Regulation Antibodies - Chromatin_regulation
AP6136a, DMAP1 Antibody (C-term), WB, IHC, E, H. AP7053b, DNA PK (PRKDC) Antibody (C-term), IHC, E, H. AP7053c, DNA PK (PRKDC) Antibody (Center), IHC, E,
H ...
http://www.abgent.com/products/category/nuclear_signaling/ch...
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Search Results
Cg-Prkdc Emv30 Tg(HLA-A/H2-D/B2M)1Dvs/DvsJ JAX® Mice Database ... Cg- Prkdc B2m Il2rg/SzJ JAX® Mice Database ...
http://www.jax.org/search/Main.jsp?sg=0&qt=xenograft&page=3...
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