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EIF2AK2
| Symbol: | EIF2AK2 | | Name(s): | eukaryotic translation initiation factor 2-alpha kinase 2 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | EIF2AK1, MGC126524, PKR, PRKR | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18023289 |
PrP aggresomes initiate a cell stress response by activating the RNA-dependent protein kinase (PKR). |
| 18063576 |
PKR and PKR-like endoplasmic reticulum kinase induce the proteasome-dependent degradation of cyclin D1 via a mechanism requiring eukaryotic initiation factor 2alpha phosphorylation |
| 18087277 |
Phosphorylation of PKR may be an important initiator of muscle wasting in cancer patients. |
| 12447867 |
Observational study of gene-environment interaction. (HuGE Navigator) |
| 12944978 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17851256 |
Airway smooth muscle cells expressed PKR but it did not seem to be involved in poly I:C effects on muscarinic receptors. |
| 17977969 |
the paramyxovirus P/V gene products limit induction of PKR by limiting the synthesis of aberrant viral mRNAs and double-stranded RNA and thus prevent the shutdown of translation |
| 17959656 |
the single-cycle yield of delta-E3L virus was increased by nearly 2 log10 in PKR-deficient cells over the impaired growth in PKR-sufficient cells. |
| 17686861 |
PKR was not necessary for Sendai virus-induced IFN synthesis, suggesting that PKR is particularly important for recognition of WNV infection |
| 18048689 |
study reports that RNAs with very limited secondary structures activate PKR in a 5'-triphosphate-dependent fashion in vitro and in vivo | →View more information from publications. |
Recent Publications on EIF2AK2: |  |
Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors.
Protein kinase PKR (also known as EIF2AK2) is activated during viral... | 30th January, 2009
| Laboratory of Gene Regulation and Development, Eunice Kennedy Shriver
| Nat Struct Mol Biol. 2009 Jan;16(1):63-70. Epub 2008 Nov 30.
DOI Direct Link |
Dengue virus regulates type I interferon signalling in a strain-dependent manner in human cell lines.
Outbreaks of dengue disease are constant threats to tropical and... | 13th January, 2009
| Novartis Institute for Tropical Diseases, 10, Biopolis Road, #05-01
| J Gen Virol. 2008 Dec;89(Pt 12):3052-62.
DOI Direct Link |
Double stranded RNA activated EIF2 alpha kinase (EIF2AK2; PKR) is associated with Alzheimer's disease.
Sporadic Alzheimer's disease (AD) appears to be the consequence of the... | 22nd August, 2008
| Departamento de Biologia Molecular and Centro de Biologia Molecular Severo
| Neurobiol Aging. 2008 Aug;29(8):1160-6. Epub 2007 Apr 8.
DOI Direct Link |
Interactions between the products of the Herpes simplex genome and Alzheimer's disease susceptibility genes: relevance to pathological-signalling cascades.
The products of the Herpes simplex (HSV-1) genome interact with many... | 29th July, 2008
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| Neurochem Int. 2008 May;52(6):920-34. Epub 2007 Nov 23.
DOI Direct Link |
Comparative analysis of vertebrate EIF2AK2 (PKR) genes and assignment of the equine gene to ECA15q24-q25 and the bovine gene to BTA11q12-q15.
The structures of the canine, rabbit, bovine and equine EIF2AK2 genes were... | 10th November, 2006
| Biology Department, Georgia State University, Atlanta, 30302, USA.
| Genet Sel Evol. 2006 Sep-Oct;38(5):551-63. Epub 2006 Sep 6.
DOI Direct Link |
→View more research publications. |
EIF2AK2 results (if any) from reagent suppliers | 
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PKR (PRKR) Antibody (C-term)
(RIGHT)Western blot analysis of EIF2AK2 (arrow) using PRKR Antibody (C-term) ( Cat.#AP8151b). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or
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http://www.abgent.com/products/catalog_no/AP8151b...
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CKOZFN1130 CompoZr™ Knockout ZFN Kit human EIF2AK2 (NM_002759)
CKOZFN1130 CompoZr Knockout ZFN Kit human EIF2AK2 (NM_002759) CompoZr Knockout ZFNs create targeted double strand breaks at a gene specific target locus.
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...
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PKR (B-10) Antibody sc-6282
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, EIF2AK2, 5610, 2p22.2, NM_002759 ...
http://www.scbt.com/datasheet-6282-pkr-b-10-antibody.html...
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PRKR Antibody
Cells were transfected with Transfection Reagent alone (Lane 1), 100nM ON- TARGETplus siCONTROL Non-Targeting Pool (Lane 2), or 100nM ONTARGETplus EIF2AK2
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http://www.piercenet.com/Products/browse.cfm?fldID=E890ABFE-...
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P6493 Anti-phospho-PKR (pThr451) antibody produced in rabbit ...
application(s), immunoblotting: 1:1000 using human HeLa cells stimulated with IFNγ and calyculin. Gene Information, human ... EIF2AK2(5610) ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=P649...
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Polyclonal Antibody to Protein kinase R (PRKR)
Principal Names: EIF2AK2; PRKR; PKR; EIF2AK1, eukaryotic translation ... Official Gene Symbol: EIF2AK2 Gene ID: 5610 (Human) 19106(Mouse) Gene Map Locus:
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http://www.imgenex.com/tds/IMG-5120A.pdf...
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Hepatitis C Virus E2 antibody (ab20044) | Abcam
Hepatitis C E2 is a virus envelope glycoprotein which forms a heterodimer with the E1 protein. E2 inhibits human EIF2AK2/PKR activation, preventing t...
http://www.abcam.com/Hepatitis-C-Virus-E2-antibody-ab20044.h...
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