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AZGP1


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Symbol:AZGP1
Name(s):alpha-2-glycoprotein 1, zinc-binding
Type:protein-coding
Organism:Homo sapiens
Synonyms:ZA2G, ZAG
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17724461 Elevated mRNA levels of AZGP1 is associated with lung adenocarcinoma
16598739 This study characterized ZAG protein (AZGP1) expression in prostate cancer using a semi-automated system. ZAG expression level found to have an independent prognostic value for pT2 patients.
15620688 Human adipocytes express and secrete ZAG, with ZAG expression being regulated particularly through TNF-alpha and the PPARgamma nuclear receptor.
14983038 ZAG gene expression and protein were detected in human adipose tissue.
16475792 Arg-73 projects into one end of the binding groove and is the sole charged amino acid adjacent to the ligand. Replacing this amino acid with alanine abolished ligand binding and closed the groove to solvent.
15477100 x-ray crystallographic analysis of ligand binding by Zn-alpha2-glycoprotein

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDZn-alpha2-glycoproteinintegrin alpha-V precursor--Pubmed
HPRDZn-alpha2-glycoproteinintegrin alpha-V precursor--Pubmed

Recent Publications on AZGP1:

Pubmed Logo
A role for GATA-2 in transition to an aggressive phenotype in prostate cancer through modulation of key androgen-regulated genes.
GATA-2, a member of the GATA family of transcription factors, is involved...
18th August, 2009
Cancer Research Program, Garvan Institute of Medical Research, Sydney, New Oncogene. 2009 Oct 29;28(43):3847-56. Epub 2009 Aug 17.
DOI Direct Link
Serum zinc-alpha2-glycoprotein correlates with adiposity, triglycerides, and the key components of the metabolic syndrome in Chinese subjects.
CONTEXT: Zinc-alpha2-glycoprotein (ZAG) is a 40-kDa circulating...
7th August, 2009
Department of Medicine, The University of Hong Kong, Hong Kong SAR, China. J Clin Endocrinol Metab. 2009 Jul;94(7):2531-6. Epub 2009 Apr 7.
DOI Direct Link
Cigarette smoking induces overexpression of a fat-depleting gene AZGP1 in the human.
BACKGROUND: Smokers weigh less and have less body fat than nonsmokers....
12th June, 2009
Department of Medicine, Weill Medical College of Cornell University, New Chest. 2009 May;135(5):1197-208. Epub 2009 Feb 2.
DOI Direct Link
Differential gene expression in human conducting airway surface epithelia and submucosal glands.
Human conducting airways contain two anatomically distinct epithelial cell...
4th February, 2009
Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA. Am J Respir Cell Mol Biol. 2009 Feb;40(2):189-99. Epub 2008 Aug 14.
DOI Direct Link
AZGP1 autoantibody predicts survival and histone deacetylase inhibitors increase expression in lung adenocarcinoma.
INTRODUCTION: The importance of alpha-2-glycoprotein 1, zinc (AZGP1) in...
30th January, 2009
Department of Surgery, University of Michigan Medical School, Ann Arbor, J Thorac Oncol. 2008 Nov;3(11):1236-44.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7612181 Dual variable domain immunoglobulin and uses thereof
7588771 Microorganisms for therapy
7588767 Microorganisms for therapy
7371736 Gene expression profiling based identification of DKK1 as a potential therapeutic targets for controlling bone loss
7308364 Diagnosis of multiple myeloma on gene expression profiling

View more patents.

AZGP1 results (if any) from reagent suppliers

Google CSE Logo
ZAG (1D4) Antibody sc-13585
AZGP1 mRNA levels in normal human lung tissue correlate with lung cancer disease status. Oncogene. 27: 1650-1656. View PubMed Entry ...
http://www.scbt.com/datasheet-13585-zag-1d4-antibody.html...

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BioVendor R&D - Molecules \ Zinc-Alpha-2-Glycoprotein
Zinc-Alpha-2-Glycoprotein (ZA2G, ZAG, AZGP1). Zinc-alpha-2-glycoprotein (ZAG) is found in body fluids such as serum, sweat, and seminal and breast cyst ...
http://www.biovendor.com/molecule/zinc-alpha-2-glycoprotein...

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ZAG (6G2) Antibody sc-21721
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIMâ„¢ Number. Human, AZGP1, 563, 7q22.1, NM_001185 ...
http://www.scbt.com/datasheet-21721-zag-6g2-antibody.html...

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BioVendor R&D - Antibodies \ Zinc-Alpha-2-Glycoprotein (ZA2G ...
Other names: ZA2G, ZAG, AZGP1, Product of BioVendor. Product: Size: New: RD184093100, 0.1 mg. Files: Datasheet PDFMSDS ...
http://www.biovendor.com/product/antibodies/zinc-alpha-2-gly...

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GCDFP15 antibody, GCDFP15 [23A3] Antibody, Mouse Monoclonal Antibody
Interacts with AZGP1. Subcellular Location: Secreted (Probable). Tissue Specificity: Expressed in pathological conditions of the mammary gland and in
...
http://www.genwaybio.com/product_info.php?products_id=192220...

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Zinc-Alpha-2-Glycoprotein (ZA2G) Human, Rabbit Polyclonal Antibody
Other names: ZA2G, ZAG, AZGP1. Research topic. Energy metabolism and body weight regulation, Oncology. Preparation. The antibody was raised in rabbits by ...
http://www.biovendor.com/product/antibodies/zinc-alpha-2-gly...

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ZAG (E-20) Antibody sc-11243
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIMâ„¢ Number. Mouse, Azgp1, 12007, 5 G2, Q64726 ...
http://www.scbt.com/datasheet-11243-zag-e-20-antibody.html...

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