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B2M


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Gene DB Home
Symbol:B2M
Name(s):beta-2-microglobulin
Type:protein-coding
Organism:Homo sapiens
Synonyms:-
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17597407 Beta-2 microglobulin accumulates in the majority of gastric tissue of patients with active gastritis who were H pylori positive, whereas no accumulation was found in H. pylori negative patients.
18036353 High molecular weight B27 is characterized by high secondary structural content, structural stability, stability to proteolysis by trypsin, and structural features that are both partly native-like, and partly non-native-like.[
17852800 The cystatin C, beta2-microglobulin and beta-trace protein levels displayed changes with increased levels in the third trimester but unaltered levels during the first and second trimesters.
17929129 HLA-B27 has a role in Beta 2-microglobulin amyloid deposit, as shown in transgenic rats
17646174 although the formation of beta2-microglobulin fibrils was enhanced under acidic conditions, it remains unknown if it is related to the increased propensity for the disappearance of the beta-bulge in strand D
18022010 B2M level measured at first autologous hematopoietic stem cell transplantation is a useful predictor for progressin in multiple myeloma.
17693474 biophysical analysis of the protofibril model for the full-length beta2m protein
18024396 beta2M level was an independent prognostic marker in patients with follicular lymphoma treated with anthracycline
17681531 Results describe the heat-induced conversion of beta(2)-microglobulin and hen egg-white lysozyme into amyloid fibrils.
17766066 Significant association between urinary beta2-microglobulin excretion and cancer mortality in cadmium polluted area.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDalpha-2-macroglobulin precursorbeta-2-microglobulin precursor--Pubmed
HPRDalpha-2-macroglobulin precursorbeta-2-microglobulin precursor--Pubmed
HPRDBeta 2 microglobulinhemochromatosis protein isoform 1 precursor--Pubmed
HPRDBeta 2 microglobulinCD1D antigen precursor--Pubmed
HPRDBeta 2 microglobulinmajor histocompatibility complex, class I, G precursor--Pubmed
HPRDBeta 2 microglobulincalreticulin precursor--Pubmed
HPRDBeta 2 microglobulinmajor histocompatibility complex, class I, E precursor--Pubmed
HPRDBeta 2 microglobulinCD1E antigen, e polypeptide--Pubmed
HPRDbeta-2-microglobulin precursorCalreticulin--Pubmed
HPRDbeta-2-microglobulin precursorHLA G--Pubmed

Recent Publications on B2M:

Pubmed Logo
Conceptus-uterus interactions in pigs: endometrial gene expression in response to estrogens and interferons from conceptuses.
This review highlights information on conceptus-uterus interactions in the...
24th October, 2009
Department of Veterinary Integrative Biosciences, College of Veterinary Soc Reprod Fertil Suppl. 2009;66:321-32.
Enhanced solute removal with intermittent, in-center, 8-hour nocturnal hemodialysis.
Advances in the dialysis technique and increasing urea Kt/V have not...
21st October, 2009
Milford Hemodialysis Center, Renal Research Institute, Milford, Hemodial Int. 2009 Oct;13(4):487-91.
DOI Direct Link
Identification of beta2-microglobulin as a potential target for ovarian cancer.
Ovarian cancer is one of the most lethal gynecological cancers....
16th October, 2009
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Cancer Biol Ther. 2009 Dec 2;8(24).
Reference gene selection for head and neck squamous cell carcinoma gene expression studies.
BACKGROUND: It is no longer adequate to choose reference genes blindly. We...
14th October, 2009
Service d'ORL et Chirurgie Maxillo-faciale, Centre Hospitalier BMC Mol Biol. 2009 Aug 3;10:78.
DOI Direct Link
Identification of valid reference genes during the differentiation of human myoblasts.
BACKGROUND: Analysis of RNA expression using real-time PCR (qRT-PCR)...
14th October, 2009
Department of Otolaryngology, Head and Neck Surgery, University Hospital BMC Mol Biol. 2009 Jul 2;10:66.
DOI Direct Link

View more research publications.

Press Releases on B2M:

BioPortfolio Logo
DermTech Names Herbert A. Fritsche, Ph.D., Chief of Clinical Chemistry at M.D. Anderson Cancer Center to Company's Scientific Advisory Board 3rd June, 2008 DermTech

LA JOLLA, Calif., June 3 /PRNewswire/ -- DermTech, a biotechnology company developing molecular diagnostics for the early detection of melanoma and other diseases, today announced that Herbert

Clinical Trials:

Clinical Trials Logo
Study of beta2-Microglobulin Removal by Standard Versus New High Cut-Off Haemodialysis Membrane

Patents:

Patents logo
US Patent No.Title
7323300 Methods for cancer prognosis and diagnosis
7399838 Single chain class I major histo-compatibility complexes
7411048 Diagnostic method for diseases by screening for hepcidin in human or animal tissues, blood or body fluids
7416851 Method of diagnosis/prognosis of human chronic lymphocytic leukemia comprising the profiling of LPL/ADAM genes
7432049 Compositions and methods relating to osteoarthritis

View more patents.

B2M results (if any) from reagent suppliers

Google CSE Logo
beta-2-Microglobulin Antibody / beta-2-Microglobulin Antibodies
β-2-Microglobulin (B2M-01) Antibody, sc-51509, mouse IgG2a, FL (h) ... beta-2- Microglobulin specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles ...
http://www.scbt.com/table-beta-2-microglobulin.html...

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beta 2 Microglobulin antibody [B2M-01] (ab759) | Abcam
Mouse monoclonal [B2M-01] to beta 2 Microglobulin. Beta 2 Microglobulin non- covalently associates with the 44 kDa alpha chain to form the HLA Class I ...
http://www.abcam.com/beta-2-microglobulin-antibody-b2m-01-ab...

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β-2-Microglobulin (B2M-01) Antibody sc-51509
Indirect FCM analysis of human peripheral blood leukocytes stained with β-2- Microglobulin (B2M-01), followed by PE-conjugated goat anti-mouse IgG2a: sc-3765
...
http://www.scbt.com/datasheet-51509-beta-2-microglobulin-b2m...

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The Abcam catalog
beta 2 Microglobulin antibodies. ... beta 2 Microglobulin antibody [B2M-01] ( Phycoerythrin). Flow Cyt. Specific publication references. Mouse monoclonal ...
http://www.abcam.com/index.html?t=225&pt=1&c=488...

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B2M monoclonal antibody (M01)
Immunofluorescence of monoclonal antibody to B2M (AT1251a) on HeLa cell . ... Western blot analysis of B2M over-expressed 293 cell line, cotransfected with
...
http://www.abgent.com/products/catalog_no/AT1251a_B2M_monocl...

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Exbio antibodies - Mouse Monoclonal to beta2-microglobulin B2M-01 ...
The antibody B2M-01 reacts with beta2-microglobulin (β2M) associated with cell- surface MHC Class I molecules and other membrane antigens as well as with ...
http://www.exbio.cz/products/clone.py?idclone=CLO00000000000...

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Anti-beta-2 Microglobulin Monoclonal Antibody
Monoclonal Antibody against beta-2 Microglobulin for use in ELISA, Flow Cytometry, Immunoprecipitation, Radioimmune Assays, Western Blot.
http://www.bioreagents.com/products/productDetails/productDe...

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2-microglobulin lateral flow | bovine b2m cd1d | b2m ko | microglobulin beta 2 | Biochemistry of b2m | beta 2 microglobulin real time PCR | b2m conversion | beta 2 microglobulin placenta | b2m structural features | .


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