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BAD


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Gene DB Home
Symbol:BAD
Name(s):BCL2-antagonist of cell death
Type:protein-coding
Organism:Homo sapiens
Synonyms:BBC2, BCL2L8
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18006502 Raf-1 in beta-cells led to a striking loss of Bad phosphorylation at serine 112 and an increase in the protein levels of both Bad and Bax
17900801 AG490 enhances UCN-01-induced cytotoxicity in p53 defective cell lines by suppression of BAD phosphorylation and induction of BAX and PARP cleavage
17696989 reelin binds to apoE receptors activating the PI3 K/Akt pathway causing phosphorylation of BAD which protects cells from apoptosis
17499381 The presence of wild type PRV US3, but not of the point-mutated PRV US3, results in phosphorylation of the pro-apoptotic Bad protein in PRV-infected HEp-2 cells.
17670745 a novel role for BAD in cell cycle regulation dependent upon its phosphorylation state and independent of the BAD/BCL2 interaction and apoptosis.
17393317 Expression of p-BAD was increased in the colorectal cancer cells and may possibly alter the cell death regulation during colorectal tumorigenesis.
17696955 decreased expression of p-BAD in malignant gastric epithelial cells suggested loss of p-BAD expression may play a role in gastric tumorigenesis; data also suggest BAD mutation may not be a direct target of inactivation in gastric tumorigenesis
17404594 p53 can form a complex with dephosphorylated Bad thereby converting it to a pro-apoptotic player.
17287851 Akt/Bad pathway generates a progressive resistance to apoptosis, at a time HTLV-I genes expression is silenced.
17541305 Bcl-2 induces the expression of matrix metalloproteinases in renal cell tumors grown in the orthotopic sites, though no appreciable effects were observed in vitro.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDBCL2 antagonist of cell deathalpha-synuclein isoform NACP140--Pubmed
HPRDBCL2 antagonist of cell deathB-cell lymphoma protein 2 alpha isoform--Pubmed
HPRDBCL2 antagonist of cell deathprotein phosphatase 1, catalytic subunit, alpha isoform 3--Pubmed
HPRDBCL2 antagonist of cell deathS100 calcium binding protein A10--Pubmed
HPRDBCL2 antagonist of cell deathtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide--Pubmed
HPRDBCL2 antagonist of cell deathtyrosine 3/tryptophan 5 -monooxygenase activation protein, eta polypeptide--Pubmed
HPRDBCL2 antagonist of cell deathtyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide--Pubmed
HPRDBCL2 antagonist of cell deathBCL2-related protein A1 isoform 1--Pubmed
HPRDBCL2 antagonist of cell deathBCL2-like 2 protein--Pubmed
HPRDBCL2 antagonist of cell deathtyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide--Pubmed

Recent Publications on BAD:

Pubmed Logo
Immunohistochemical Detection of Phospho-Akt, Phospho-BAD, HER2 and Oestrogen Receptors alpha and beta in Malaysian Breast Cancer Patients.
Activation of Akt signaling pathway has been documented in various human...
3rd November, 2009
Department of Pathology, Faculty of Medicine and Health Sciences, Pathol Oncol Res. 2009 Nov 1.
DOI Direct Link
Homology modelling of a sensor histidine kinase from Aeromonas hydrophila.
Aeromonas hydrophila has been implicated in extra-intestinal infection and...
3rd November, 2009
Infectious Disease Biology, Institute of Life Sciences, Nalco Square, J Mol Model. 2009 Oct 29.
DOI Direct Link
Left superior vena cava conduction to the left atrium unmasked by adenosine in a patient with paroxysmal atrial fibrillation during pulmonary vein isolation.
The use of adenosine in unmasking potential 'trigger' activity in a...
3rd November, 2009
1Division of Cardiology, Arrhythmia and Electrophysiology Section, Europace. 2009 Oct 31.
DOI Direct Link
[Contribution of electronic data interchange to haemovigilance in a hospital - Experience in the University Hospital of Reims.]
OBJECTIVE: This study aims to describe concret results, in a hospital, of...
3rd November, 2009
Unite d'hemovigilance, CHU, 45, rue Cognacq-Jay, 51092 Reims, France. Transfus Clin Biol. 2009 Oct 30.
DOI Direct Link
Big Bad BCCs: craniofacial resection and reconstruction for atypical basal cell carcinoma.
Basal cell carcinoma (BCC) is the most common malignancy of the body and...
3rd November, 2009
St Andrews Centre for Plastic Surgery and Burns, Regional Head and Neck J Plast Reconstr Aesthet Surg. 2009 Oct 28.
DOI Direct Link

View more research publications.

Press Releases on BAD:

BioPortfolio Logo
Octapharma Group and Fresenius Kabi Enter Into an Exclusive License, Development and Supply Agreement for a HESylated Recombinant Protein 28th October, 2009 Octapharma

BAD HOMBURG, Germany and LACHEN, Switzerland, Oct. 28 /PRNewswire/ -- Octapharma Group and Fresenius Kabi have signed a License, Development and Supply Agreement regarding the use of Fresenius

Waylon Lewis of elephantjournal.com: YOGA JOURNAL CONFERENCE... & GHEE VS. OLIVE OIL. 2nd October, 2009 elephantjournal.com

BOULDER, Colo., Oct. 2 /PRNewswire/ -- elephantjournal.com: CAN OLIVE OIL BE BAD FOR YOU? AND WHAT IS GHEE?

One benefit of using ghee over olive oil? It has a smoking

Treatment Approval - a Step Forward in Managing Severe Psoriasis in Children 8th January, 2009

TAPLOW, England, January 8 /PRNewswire/ -- Wyeth Pharmaceuticals has today announced that Enbrel(R) (etanercept) is approved for the treatment of chronic severe plaque psoriasis in children aged 8

SuperGen Reports 2008 Second Quarter Financial Results 4th August, 2008 SuperGen, Inc.

DUBLIN, Calif., Aug. 4 /PRNewswire-FirstCall/ -- SuperGen, Inc. (Nasdaq: SUPG), a pharmaceutical company dedicated to the discovery, rapid development and commercialization of therapies for

EntreMed's ENMD-2076 Demonstrates Antitumor Activity in Multiple Myeloma Model 2nd June, 2008 EntreMed, Inc.

ROCKVILLE, Md., June 2 /PRNewswire-FirstCall/ -- EntreMed, Inc. (Nasdaq: ENMD), a clinical-stage pharmaceutical company developing therapeutics for the treatment of cancer and inflammatory

BioNews Results for BAD

: RSS Logo
BioPortfolio Logo
Swine flu blog: Black elderberry - the latest miracle cure
Whitehaven News:  Nov 14 2009 2:33PM Matching: bad
No need to fast for cholesterol test
PhysOrg.com:  Nov 14 2009 10:32PM Matching: bad
Breakthrough in cancer studies
Chelmsford Weekly News:  Nov 14 2009 2:46PM Matching: bad
Other facts about the mayors 'leadership'
Northwest Explorer:  Nov 14 2009 2:11PM Matching: bad
Geisinger centers report seeing recent decrease in flu cases
Pocono Record:  Nov 14 2009 7:17AM Matching: bad
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Clinical Trials:

Clinical Trials Logo
Dose Intensification Study in Refractory Germ Cell Tumors With Relapse and Bad Prognosis

Patents:

Patents logo
US Patent No.Title
7612829 2:2 and 3:2 pull-down detection techniques
7613180 Media communication apparatus and media communication method
7613182 Distributed and secured method and system for protecting and distributing audiovisual flows
7613209 System and method for egress packet marking
7613212 Centralized clock synchronization for time division multiplexed traffic transported over Ethernet networks

View more patents.

BAD results (if any) from reagent suppliers

Google CSE Logo
Bad antibody (ab13998) | Abcam
Chicken polyclonal to Bad. Bad is a member of the Bcl2 family and acts to promote apoptosis by forming heterodimers with the survival proteins Bcl2 and
...
http://www.abcam.com/bad-antibody-ab13998.html...

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Phospho-Bad (Ser112) Antibody #9291
Phospho-Bad (Ser112) Antibody detects endogenous levels of Bad only when phosphorylated at Ser112. The Ser112 nomenclature is based upon the mouse
sequence. ...
http://www.cellsignal.com/products/9291.html...

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Bad Antibody / Bad Antibodies
Bad Antibody / Bad Antibodies. ... Bad specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-bad.html...

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Phospho-Bad Antibody Sampler Kit #9105
The Phospho-Bad Antibody Sampler Kit provides an economical means to investigate the role of Bad protein in apoptosis. The kit contains primary and ...
http://www.cellsignal.com/products/9105.html...

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p-Bad (Ser 136) Antibody sc-12969
See how others have used p-Bad (Ser 136): sc-12969 antibody and or p-Bad (Ser 136) antibody ... p-Bad (Ser 136)-R: sc-12969-R. Western blot analysis of Bad
...
http://www.scbt.com/datasheet-12969-p-bad-ser-136-antibody.h...

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Phospho-Bad (Ser155) Antibody #9297
Phospho-Bad (Ser155) Antibody detects transfected levels of Bad only when phosphorylated at Ser155. This antibody does not detect Bad phosphorylated at
...
http://www.cellsignal.com/products/9297.html...

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p-Bad (Ser 112) Antibody sc-7998
See how others have used p-Bad (Ser 112): sc-7998 antibody and or p-Bad (Ser ... p-Bad (Ser 112)-R: sc-7998-R. Western blot analysis of phosphorylated Bad ...
http://www.scbt.com/datasheet-7998-p-bad-ser-112-antibody.ht...

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