Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18006502 |
Raf-1 in beta-cells led to a striking loss of Bad phosphorylation at serine 112 and an increase in the protein levels of both Bad and Bax |
| 17900801 |
AG490 enhances UCN-01-induced cytotoxicity in p53 defective cell lines by suppression of BAD phosphorylation and induction of BAX and PARP cleavage |
| 17696989 |
reelin binds to apoE receptors activating the PI3 K/Akt pathway causing phosphorylation of BAD which protects cells from apoptosis |
| 17499381 |
The presence of wild type PRV US3, but not of the point-mutated PRV US3, results in phosphorylation of the pro-apoptotic Bad protein in PRV-infected HEp-2 cells. |
| 17670745 |
a novel role for BAD in cell cycle regulation dependent upon its phosphorylation state and independent of the BAD/BCL2 interaction and apoptosis. |
| 17393317 |
Expression of p-BAD was increased in the colorectal cancer cells and may possibly alter the cell death regulation during colorectal tumorigenesis. |
| 17696955 |
decreased expression of p-BAD in malignant gastric epithelial cells suggested loss of p-BAD expression may play a role in gastric tumorigenesis; data also suggest BAD mutation may not be a direct target of inactivation in gastric tumorigenesis |
| 17404594 |
p53 can form a complex with dephosphorylated Bad thereby converting it to a pro-apoptotic player. |
| 17287851 |
Akt/Bad pathway generates a progressive resistance to apoptosis, at a time HTLV-I genes expression is silenced. |
| 17541305 |
Bcl-2 induces the expression of matrix metalloproteinases in renal cell tumors grown in the orthotopic sites, though no appreciable effects were observed in vitro. |
| 17544220 |
Lysophosphatidic acid prevents apoptosis of Caco-2 colonic neoplasms via activation of mitogen-activated protein kinase and phosphorylation of BAD. |
| 17438366 |
BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between BECN1 and BAX and Bcl-2. |
| 11781193 |
expression in normal, hyperplastic and carcinomatous human prostate |
| 11878929 |
results suggest that direct interaction of Bad with pro-survival members of the Bcl-2 family contributes to the progress of Sindbis virus-induced apoptosis |
| 16728406 |
antiapoptotic signaling pathways activated by vasoactive intestinal polypeptide, epidermal growth factor, and phosphatidylinositol 3-kinase in prostate cancer cells converge on BAD |
| 12965220 |
Mutation of BAD within the BH3 domain modulates its apoptotic function. |
| 14767529 |
Bad is increased in quercetin-treated nasopharyngeal carcinoma cells |
| 15767261 |
AR and IGF1 cooperate to prevent apoptosis by activating a specific PKC-p90(rsk)-dependent pathway, which leads to Bad and Bax inactivation. |
| 12084714 |
BAD cleavage and apoptosis in tumor cells in response to raloxifene |
| 15731037 |
degraded during Chlamydia trachomatis infection |
| 15751984 |
A recombinant fusion protein linking human granulocyte-macrophage colony-stimulating factor to the N-terminus of the proapoptotic protein BAD delivers BAD into tumor cells, where it restores the apoptotic pathway. |
| 12239175 |
role of PI3-kinase-dependent phosphorylation and altered transcription in cytokine-mediated neutrophil survival |
| 15226424 |
constitutively active Rac1 is shown to stimulate the phosphorylation of Bad, thereby suppressing drug-induced caspase activation and apoptosis in human lymphoma cells; Rac1 activation leads to Bad phosphorylation specifically at serine-75 |
| 12657644 |
study suggests that the cleavage of 14-3-3 protein during apoptosis promotes cell death by releasing the associated Bad protein from the 14-3-3 protein and facilitates Bad translocation to the mitochondria and its interaction with Bcl-x(L) |
| 15901741 |
BAD induces apoptosis upon detecting the coincidence of G2/M phase and growth factor deprivation |
| 16603546 |
the interaction of BAD with membranes is tied to binding of 14-3-3 protein and activation and membrane translocation of Bcl-XL |
| 17011751 |
Raf-1 and B-Raf promote protein kinase C theta interaction with BAD. |
| 17446862 |
The functional and physical interaction between Bcl-X(L) and a BH3-like domain in BECN1 was studied. |
| 16297499 |
Bcl-xL mRNA overexpression may suggest poor prognosis in NSCLC. |
| 17110373 |
dissociation of Bad from Bcl-xL and an increase in the intracellular level of Bcl-xL are responsible for development of acquired TRAIL resistance |
| 16148027 |
Bax, Bad, and Bim are upregulated, while Bcl-2 is downregulated in human neuroblastoma cells treated with propargylamine |
| 16484005 |
There was no somatic mutation of BH3 domains of Bad, Bmf and Bcl-G genes in transitional cell carcinoma samples. The data presented here indicate that BH3 domain mutation of these genes is rare in TCCs and may not contribute to the pathogenesis of TCCs. |
| 16785131 |
Cytogenetic investigation of a nodal diffuse large B cell lymphoma carrying an IGH-BCL2-fusion revealed a homogeneously staining region at chromosome 1p21-22. |
| 16847055 |
EGF protects prostate cancer cells from apoptosis by inducing BAD phosphorylation via redundant signaling pathways |
| 12087097 |
effects of paclitaxel on BAD phosphorylation in ovarian cancer cells |
| 12954615 |
BAD is a substrate for pim-2 oncogene proto-oncogene |
| 16767165 |
Phosphorylation of BAD or inhibition of its translocation to the mitochondria are critical survival pathways in LNCaP tumor cells. |
| 16908594 |
Bad translocation to mitochondria plays a critical role in Tetrahydrocannabinol-induced apoptosis in Jurkat cells. |
| 16978419 |
Mycobacterium leprae inhibits apoptosis in THP-1 cells by downregulation of Bad and Bak and upregulation of Mcl-1 gene expression. |
| 17557568 |
data presented here indicate that BH3 domain mutation of the proapoptotic genes Bad, Bmf and Bcl-G is rare in laryngeal squamous cell carcinoma and may not contribute to the apoptosis-resistance mechanisms of laryngeal squamous cell carcinoma |
| 15231831 |
mechanisms that regulate the conversion of BAD from an anti-death to a pro-death factor include alternative splicing that produces N-terminally truncated BAD(S)and conversion by caspases into a pro-death fragment that resembles the short splice variant |
| 15849194 |
Pak1-dependent Raf-1 phosphorylation regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association |
| 12754297 |
BAD-mediated sensitivity of prosstatic cancer cells to TRAIL depends on the phosphorylation status of BAD WT and tBAD. |
| 17420275 |
GATA1 and GFI1B interplay to regulate bcl-X protein transcription. |
| 11839683 |
Protein kinase A RIalpha antisense inhibition of PC3M prostate cancer cell growth: Bcl-2 hyperphosphorylation, Bax up-regulation, and Bad-hypophosphorylation |
| 15033904 |
Bad gene is occasionally mutated in colon cancer |
| 16843435 |
doxorubicin-stimulated phosphorylation of Bad in cells expressing dominant negative p38 MAPK was impeded by the inhibition of PI3-kinase |
| 16932738 |
AKT-induced BAD phosphorylation and its subsequent cytoplasmic sequestration by 14-3-3zeta is a major mechanism responsible for the postponement of UVB-induced apoptosis in human keratinocytes. |
| 16949642 |
The high expression of bad in Hodgkin and Reed-Sternberg cells in most classical Hodgkin's lymphomas (HLs)indicates that this protein may play predominant role in the regulation of apoptosis in classical HLs. |
| 16710454 |
Sequestration of BAD away from mitochondria provides C. trachomatis with mechanism to protect host cell from apoptosis via interaction of a C. trachomatis-encoded inclusion protein with host-cell phosphoserine-binding protein. (BAD protein) |
