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PTCH1
| Symbol: | PTCH1 | | Name(s): | patched homolog 1 (Drosophila) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | BCNS, FLJ26746, FLJ42602, HPE7, NBCCS, PTC, PTC1, PTCH, PTCH11 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18059486 |
prevalence of PTCH and p53 mutations for basal cell carcinoma is 63% and 46% in psoralen /UVA associated cancer |
| 12516098 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 15534865 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15598212 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15888139 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16645598 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18068533 |
there was no evidence of methylation in the PTCH1-1B promoter in the MB cases examined, nor was there methylation in the control cerebellum samples. |
| 17950424 |
A patient with nevoid basal-cell carcinoma syndrome and West syndrome. The patient had a heterozygous mutation (insertion of TGGC) in the PTCH gene. |
| 17295047 |
Reduced expression of PTCH is associated with breast cancer |
| 17597822 |
a (UV-) mutated PTCH gene is important for sporadic BCC formation independent of clinical phenotype and the IVS16-80G/C and/or IVS17+21G/A SNP site might be important for tumorigenesis in certain BCC patients | →View more information from publications. |
Recent Publications on PTCH1: |  |
The metalloendopeptidase gene Pitrm1 is regulated by hedgehog signaling in the developing mouse limb and is expressed in muscle progenitors.
Pitrm1 is a zinc metalloendopeptidase that has been implicated in... | 31st October, 2009
| The University of Queensland, Institute for Molecular Bioscience,
| Dev Dyn. 2009 Oct 29.
DOI Direct Link |
Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation.
Hedgehog signaling is aberrantly activated in glioma, medulloblastoma,... | 29th October, 2009
| M & M Medical Bioinformatics, Hongo 113-0033, Japan.
| Curr Mol Med. 2009 Sep;9(7):873-86.
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Identification of novel antigens with induced immune response in monoclonal gammopathy of undetermined significance.
The transformation from monoclonal gammopathy of undetermined significance... | 29th October, 2009
| Jerome Lipper Multiple Myeloma Center and LeBow Institute for Myeloma
| Blood. 2009 Oct 8;114(15):3276-84. Epub 2009 Jul 8.
DOI Direct Link |
Methylation of PTCH1a gene in a subset of gastric cancers.
AIM: To establish if PTCH1a transcriptional regulation region (TRR) is... | 23rd October, 2009
| Department of Surgery, Shanghai Xinhua Hospital, Shanghai Jiao Tong
| World J Gastroenterol. 2009 Aug 14;15(30):3799-806.
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Role of Sonic hedgehog signaling and the expression of its components in human embryonic stem cells.
Human embryonic stem cells (hESC) are characterized by their ability to... | 20th October, 2009
| Stem Cell Group, Bioprocessing Technology Institute, ASTAR (Agency for
| Stem Cell Res. 2009 Sep 16.
DOI Direct Link |
→View more research publications. |
PTCH1 results (if any) from reagent suppliers | 
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PTCH2 (L849) Antibody #2464
It does not recognize transfected levels of human PTCH1. ... Patched1 and 2 ( PTCH1 and PTCH2) are twelve-pass transmembrane proteins that function as the ...
http://www.cellsignal.com/products/2464.html...
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patched (G-19) Antibody sc-6149
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, PTCH1, 5727, 9q22.32, NM_000264 ...
http://www.scbt.com/datasheet-6149-patched-g-19-antibody.htm...
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PTCH2 (L849) Antibody
mutations that impair the ability of PTCH1 to suppress. Smo are frequently found in patients with ... transfected levels of human PTCH1. This antibody also ...
http://www.cellsignal.com/pdf/2464.pdf...
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Anti-PTCH Polyclonal Antibody
Figure 1 illustrates Western blot detection of human PTCH1 from human fetal brain lysate using PA1-4134. Mutations of the human Patched tumor suppressor ...
http://www.bioreagents.com/products/productDetails/productDe...
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GLI2 (R770) Antibody
PTCH1 (C53A3) Rabbit mAb #2468. PTCH2 (L849) Antibody #2464. PTCH2 (G1191) Antibody #2470. SUFU (C54G2) Rabbit mAb #2520. SUFU (C81H7) Rabbit mAb #2522 ...
http://www.cellsignal.com/pdf/2585.pdf...
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< 다음 5 논문 >
Mouse, Ptch1, 19206, 13 B3, Q61115 ... Basal cell carcinoma and its development: insights from radiation-induced tumors in Ptch1-deficient mice. Cancer Res. ...
http://www.scbt.com/ko/product.php?datasheet=6149&page=2&tot...
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Shh (C9C5) Rabbit mAb
PTCH1 (C53A3) Rabbit mAb #2468. PTCH2 (G1191) Antibody #2470. Phototope®-HRP Western Blot Detection System, Anti-rabbit IgG,. HRP-linked Antibody #7071 ...
http://www.cellsignal.com/pdf/2207.pdf...
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