Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18029351 |
COX-2 has the ability to enhance iNOS-induced cPLA(2)alpha S-nitrosylation and maximal PG synthesis is achieved by the synergistic interaction among iNOS, cPLA(2)alpha, and COX-2 |
| 18000398 |
Tumor COX-2 expression portends a poor prognosis for patients with resected adenocarcinoma of the pancreas, particularly in tumors > or =3 cm. |
| 18214026 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18234542 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18287876 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18311113 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18330937 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 18349295 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18350611 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 18172254 |
COX-2 overexpression in glottic cancer was associated with increased overall mortality and an increased risk of second primary cancers in head and neck cancer patients during the early follow-up period |
| 17553653 |
COX-2 overexpression was significantly correlated with depth of invasion, tumor stage and survival in esophageal squamous cell carcinoma. |
| 17350020 |
We have found the COX-2 G-765C polymorphism to be a risk factor for incident stroke in African-Americans |
| 16760271 |
COX-2 may play a key role in the development and progression of gastric adenoma |
| 17962194 |
PAR2 up-regulates cyclooxygenase-2 expression via an ERK1/2-mediated activation. |
| 18173398 |
The results of the study suggest that the -765G to C polymorphism of the COX-2 gene is associated with a decreased risk for periodontitis in Taiwanese, especially in AgP. However, the biological meaning needs further investigation. |
| 18097055 |
HIV-1 Tat was able to induce COX-2 and PGE2 synthesis in astrocytic cells through an NFAT/AP-1-dependent mechanism. |
| 18214026 |
results suggest that the polymorphisms examined in COX1 and COX2 do not affect the risk of gastric cancer |
| 18190720 |
COX-2 may up-regulate VEGF-C expression and thus promote lymph node metastasis via lymphangiogenesis pathway in human breast cancer. |
| 11309440 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12164325 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 12377741 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12433707 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12718655 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12920574 |
Observational study of genotype prevalence and gene-disease association. (HuGE Navigator) |
| 14604894 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14749922 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14754878 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15138244 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15150618 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 15167446 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15173859 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 15544595 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15550453 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 15596291 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15767339 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 15777967 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 15882925 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15930344 |
Observational study of genotype prevalence and gene-disease association. (HuGE Navigator) |
| 16024651 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16083713 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16150050 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 16181776 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16205694 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16273614 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16309832 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16344721 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 16361272 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16407418 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 16453284 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16458279 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16479190 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16489098 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18006935 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16506214 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16542464 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 16678543 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 16702043 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16733888 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16762620 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 16775170 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 16788380 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 16821264 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16840740 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16871410 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16879213 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16905570 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16959787 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17006983 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17058024 |
Observational study of gene-disease association, gene-gene interaction, and genetic testing. (HuGE Navigator) |
| 17066444 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17151091 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17171651 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17178263 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17181859 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17202846 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17214885 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17234302 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17307204 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17350020 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17355643 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 17356794 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17373929 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 17404026 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17460548 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 17479405 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17495879 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17573729 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17578436 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17581270 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17581413 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17609663 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17631383 |
Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17640058 |
Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17702963 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17851225 |
Observational study of gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17924829 |
Observational study of gene-gene interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17968676 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17999989 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18038187 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 18085997 |
Observational study of genetic testing. (HuGE Navigator) |
| 18164040 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 18167131 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 18173398 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16489533 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 18064329 |
Alternative splicing of platelet COX2 mRNA after coronary bypass grafting may be a posttranscriptional mechanism opposing transactivation of COX-2. Prevents COX-2-dependent thromboxane synthesis in the platelet, increasing the likelihood of thrombosis. |
| 17604853 |
the transcriptional activity of the COX-2 gene in colorectal cancer cells and the identification of regulatory promoter elements |
| 17936921 |
transactivation of the COX-2 promoter and MAPK pathway by cholecystokinin-2/gastrin receptor |
| 18156149 |
LPS-activated monocytes suppress T cell immune responses and induce FOXP3 expression in resting CD4+CD25- T cells through a COX-2-PGE2-dependent mechanism. |
| 17455223 |
PRKCD-mediated CREB activation regulates ghrelin-induced COX-2 expression and dinoprostone production in colonic epithelial cells. |
| 17977913 |
COX-1 and COX-2 are constitutively expressed at relatively high levels in human patellar tendon and are likely targets of COX-inhibiting drugs at rest and after physical activity. |
| 17640750 |
These results demonstrate for the first time that PLD1 and PLD2 isozymes enhance cobalt chlorde-induced COX-2 expression through differential signaling pathways in astroglioma cells. |
| 18199541 |
COX-2 expression is decreased in breast cancer cell lines and cancer specimens as compared with normal mammary epithelial cells. |
| 18027256 |
There was a statistically significant correlation between COX-2 immunoreactivity and the cytoplasmic HuR expression level in laryngeal squamous cell carcinoma. |
| 18032824 |
Stromal myofibroblasts surrounding colon adenocarcinomas are an important source of VEGF and COX-2 production. |
| 18097584 |
we analyzed the signal transduction and COX-2 expression in endometrial cancer cells |
| 18212353 |
upon stimulation with the same upstream signals, different downstream intracellular pathways regulate PTGS2 and PGDH mRNA expression |
| 18181047 |
Osteopontin, cyclooxygenase-2 and vascular endothelial growth factor synergically promote angiogenesis and metastasis in gastric cancer. |
| 17876541 |
CDX2 inhibits transcription of Cox-2 by interfering with the binding of NF-kappaB on the NF-kappaB binding site. |
| 18064740 |
Methylation may predict biochemical recurrence in prostate cancer patients undergoing radical prostatectomy. in prostate cancer patients undergoing radical prostatectomy |
| 17495879 |
Genetic variation in PTGS1 and PTGS2 may be important risk factors for the development of cardiovascular disease events. |
| 17693978 |
COX-2 and iNOS was significantly higher in chronic fatigue syndrome patients than in normal controls. |
| 17823287 |
AhR activation and COX-2 overexpression likely represent a mechanism of resistance to apoptosis in lymphoma cell lines that might be relevant for the development of lymphoma in vivo. |
| 17982644 |
COX-2 mRNA and proteins were significantly reduced by up to 80% on day 2 after COX-2 siRNA transfection to the gastric cancer cell line. |
| 18094075 |
COX-2 expression is dependent on calcium and protein kinase C |
| 17955050 |
The experiments presented here demonstrated that COX-2 transfection of a TGF-beta-sensitive cell line abrogates the growth inhibitory effects of TGF-beta. |
| 17991613 |
LTD(4) promotes formation of an atherosclerosis-protective and anti-thrombotic eicosanoid by markedly up-regulating EC cyclooxygenase-2 (COX-2). |
| 17916229 |
In healthy volunteers, COX-2 inhibition inhibited systemic PGE2/PGI2 synthesis and stimulated TXB2 release from activated platelets. |
| 17581270 |
COX-2 CA-haplotype is a risk factor for development of esophageal adenocarcinoma. |
| 17303142 |
human aortic smooth muscle cells prostacyclin 2 synthase(PGIS) gene transfer reduced peroxisome proliferator-activated receptor delta(PPAR-delta) expression and inhibited neointimal formation after balloon injury |
| 17643350 |
Data show that the Ca2+-dependent type IV cytosolic phospholipase A2 (cPLA2) is pivotally involved in the COX-2-mediated generation of PGE2 in response to a calcium ionophore. |
| 17982107 |
Jak2 ordinarily dampens and limits the duration of the PGHS-2 induction by IL-1beta. |
| 17244951 |
Our present study demonstrated a significant overexpression of COX-2 at the mRNA and protein level in the Barrett's epithelium |
| 17711445 |
The switching of linoleic acid metabolism by reversal of the expression of 15LOX-1 and COX-2 is associated with acquisition of malignant potential in colonic neoplasia. |
| 17968936 |
microparticles up-regulate the production of PGE(2) in synovial fibroblasts by inducing COX-2 and mPGES-1 in rheumatoid arthritis |
| 17222248 |
Increasing COX-2 expression in Barrett's metaplasia is significantly associated with a change in the local inflammatory reaction, but not during further progression through dysplasia to cancer |
| 17927697 |
We report that Bordetella persussis ACT ( adenylate cyclase toxin) induces COX-2 in HEK293T cells expressing Mac-1. |
| 17961495 |
Together, our results demonstrated that COX-2 expression could be induced by vanadium pentoxide in NFAT-dependent way and played an anti-apoptotic role in Beas-2B cells. |
| 17855346 |
We report that arachidonic acid lipid hydroperoxide metabolites of 5-, 12-, 15-lipoxygenase-1, and cyclooxygenase-2 oxidize the 2-Cys-peroxiredoxins 1, 2, and 3 to their sulfinic and sulfonic forms. |
| 17881124 |
Three classes of inflammatory repressors act synergistically in modulating PAF-induced up-regulation of COX-2, TNFalpha, and PGE(2) by quenching oxidative stress or inflammatory signaling, resulting in increased HN cell survival. |
| 17651852 |
These data suggest that the COX-2-dependent pathway appears to assist TMT-induced degeneration of CA1 pyramidal cells but not CA3 pyramidal cells in a corticosterone-independent manner. |
| 17970040 |
These results suggested that tumor-produced COX-2, which was associated with inhibiting apoptosis and promoting angiogenesis, provided additional prognostic information in endometrial cancer patients. |
| 17673564 |
COX-2 is expressed and enzymatically active in myocytes of skeletal muscles and hearts of humans. |
| 17560572 |
Results indicate that COX-2 is highly up-regulated during both normal and stress-induced fibroblast senescence and contributes to the establishment of the senescent characteristics. |
| 17627037 |
Results indicate that gp120 induces COX-2 transcription through NF-kappaB activation in astrocytoma cells. |
| 18006811 |
Rho-GDI beta has two roles: one that suppresses tumor progression by inhibiting migration and the other that stimulates it by enhancing Cox-2 expression |
| 17707579 |
High concentrations of specific COX2 inhibitors inhibited proliferation of esophageal tumor cell lines. |
| 16912190 |
Discoidin domain receptor family member 1-mediated Cox-2 induction is NF-kappaB dependent in breast cancer. |
| 17671679 |
VEGF, MMP2, 7 and 9, and COX-2 expression is related to progression of advanced uterine cervical cancer in young women |
| 17671709 |
High frequency of expression in central nervous system lymphomas may be associated with tumorigenesis may lead to futural therapeutic trials. |
| 17640058 |
polymorphisms are unlikely to influence colorectal adenoma recurrence and cannot be used to identify individuals who derive benefit from aspirin interventio |
| 16912160 |
Reintroduction of wild-type LKB1 into cells induced down-regulation of PEA3 resulted in reduced cyclooxygenase-2 RNA and protein expression. |
| 17657731 |
This study demonstrates a strong positive relationship between COX-2 and aromatase mRNA expression, and lends further support to the hypothesis that COX-2 is an upregulator of aromatase in breast tissue |
| 17018629 |
Aldose reductase is an obligatory mediator of growth factor-induced up-regulation of COX-2. |
| 17952860 |
Breast cancer progression is associated with the accumulation of glucocorticoid receptor in the cytoplasm of tumoral cells and the decrease of COX-2 expression. |
| 17868457 |
these results demonstrate that vGPCR induces expression of COX-2 and PGE2 that may mediate the paracrine effects of this key viral protein in KS pathogenesis. |
| 17392515 |
Data show that regulation of HuR via protein kinase C alpha-dependent phosphorylation emphasizes the importance of posttranslational modification for stimulus-dependent HuR shuttling. |
| 17578436 |
COX-2 common variants -765G-->C and -1195A-->G appear to be associated with risk of nonmelanoma skin cancer, although in different ways in the squamous cell skin carcinoma and basal cell carcinoma subgroups |
| 17683115 |
mechanism of COX-2 protein induction expression in PMN is substantially different from that operative in mononuclear phagocytes, which is highly dependent on transcriptional regulation |
| 16979925 |
The results demonstrated statistically significant increased oral mucosal staining for NF-kappaB and COX-2 following cytotoxic chemotherapy and provide further support for the role of NF-kappaB and COX-2 in the pathogenesis of mucositis. |
| 16979927 |
This study failed to demonstrate any prognostic significance of COX-2 expression alone or co-expression with HIF-1alpha or VEGF in advanced NPC. |
| 17868881 |
COX-2 probably mediates inflammatory reaction in myocardial infarction. COX-1 and COX-2 are associated with the healing processes and scar formation after myocardial infarction. |
| 17635918 |
GS-HCl inhibits COX-2 activity by preventing COX-2 co-translational N-glycosylation and by facilitating COX-2 protein turnover during translation in a proteasome-dependent manner |
| 17581812 |
low density lipoprotein (LDL) that had been denatured by freeze-thawing or oxidized LDL might be involved in the COX-2 induction |
| 17650224 |
The expression of cyclooxygenase-2 COX2) was significantly higher in esophogeal squamous cell neoplasm than in non-tumorous tissue. |
| 17550984 |
Signaling pathways involved in PTGS2 induction by hepatocyte growth factor in non-small-cell lung carcinoma are reported. |
| 17562850 |
dexamethasone reduces vasoconstriction to electrical field stimulation in rat mesenteric arteries from spontaneously hypertensive rats by decreasing COX-2 expression, decreasing the smooth muscle TXA(2) release induced by alpha-adrenoceptor activation |
| 17724132 |
Metabolism of endocannabinoids by the endothelial cell COX-2 coupled to the prostacyclin (PGI(2)) synthase activates the nuclear receptor peroxisomal proliferator-activated receptor delta, which negatively regulates the expression of tissue factor. |
| 17457030 |
results suggest that COX-2 expression may be differentially regulated among subdivisions of the hippocampus and that elevated COX-2 expression in the CA1 of Alzheimer's disease (AD) brains may be associated with AD pathology and thus cognitive dysfunction |
| 17308999 |
Patients with tumor lacking cyclooxygenase-2 expression before chemoradiotherapy are more likely to demonstrate good response to treatment. |
| 17609663 |
Our findings suggest that variation in COX2 is associated with prostate cancer risk. |
| 17710160 |
Cytoplasmic beta-catenin is associated with COX-2 overexpression, supporting the role of cytoplasmic beta-catenin in stabilizing PTGS2 (COX-2) mRNA. |
| 17572069 |
E-prostanoid receptors 2-4, but not 1, transactivated the epidermal growth factor receptor, through tumor necrosis factor-alpha converting enzyme. |
| 17525067 |
participates in placentation through EVT invasion by up-regulating PGE2 production and PGE2 receptor expression in first trimester extravillous trophoblasts |
| 17395887 |
Results show for the first time acetylation via selective degradation of histone deacetylase 1, and that recruitment of histone acetyltransferase plays an important role in diesel exhaust particulate matter-induced expression of the cyclooxygenase-2 gene. |
| 17542993 |
COX-2 is highly expressed in lobular in situ neoplasia, supporting a role for this protein in the early stage of breast carcinogenesis, representing the rationale for using COX-2 selective inhibitors in the earliest stages of breast cancer. |
| 17624243 |
Expression might be addressed as a new prognostic tool in the clinical management of oral squamous cell carcinoma. |
| 17581403 |
Results suggest that the cytoplasmic overexpression of HuR is associated with uterine cervical carcinomas with aggressive clinicopathologic features and that HuR might contribute to the stabilization of COX-2 mRNA in some uterine cervical carcinomas. |
| 17581404 |
Data support that there are significant differences between EGFR and COX-2 expressions in the 3 different histogenetic types of cervical cancer. |
| 17581413 |
A fetal polymorphism in the COX-2 gene influences the occurrence of placental malperfusion and ischemia, which may be of sufficient severity to promote or allow the development of intrauterine growth retardation. |
| 17611676 |
Results show co-expression of cyclooxygenase-2 and prostaglandin E2 receptors EP1, 2 and 4 in non-small cell lung cancer cells concomitant with the synthesis of PGE2. |
| 17573729 |
PTGS2.8473 polymorphism is associated with asthma, atopy and lung function but not plasma IgE in Chinese children. |
| 17678966 |
mechanisms leading to microglial COX-2 expression as well as its potential implication in prion disease pathogenesis remain to be established--REVIEW |
| 17681165 |
Slow transit constipation is due to abnormal levels of COX1/2 and prostaglandins, probably caused by overexpression of progesterone receptors in colonic smooth muscle. |
| 17624083 |
COX-2, MMP-2 and MMP-9 were expressed in a high percentage of primary endometrial carcinomas and their expressions may be associated closely with parameters of tumor aggressiveness. |
| 17631744 |
YKL-40 release by intervertebral disc culture may better clarify its role in the pathophysiology of discal degeneration and inflammation and its relationships with COX-2 and NO in disc tissue culture. |
| 17011110 |
Human labor is associated with increased expression of COX-2 in the myometrium. |
| 17645803 |
The major subtypes of renal epithelial neoplasms display differential aberrant CDH1, PTGS2, and RASSF1A promoter methylation levels. This gene panel might contribute to a more accurate discrimination among common renal tumors. |
| 11981837 |
COX-2 appears to be constitutively and selectively present in medullary epithelial cells of the human thymus. |
| 12124799 |
Inhibitory effect of a selective cyclooxygenase-2 inhibitor on liver metastasis of colon cancer. |
| 15013358 |
COX-2 mrna expression in peripheral blood monocytes showed marginal increase in eary postoperative period. |
| 15328521 |
Cox-2 expression is highly variable in Dukes' C colorectal tumors. |
| 15383564 |
In situ processing of COX-2-overexpressing glioma by tumor-infiltrating dendritic cells induces a tolerogenic T cell response by means of generating a CD4+ T regulatory type 1 (Tr1) response. |
| 15978332 |
COX-2 upregulation showed to be a late event and in a multivariate analysis it was associated independently with a reduced survival after surgery compared with low COX-2 expressed esophageal tumors |
| 16243808 |
High COX-2 is an independent prognostic factor in gastric cancer. |
| 11844819 |
increased expression associated with chemotherapy resistance and poor survival in cervical cancer |
| 12050157 |
expression induced by interleukin-1beta and amyloid beta 42 peptide is potentiated by hypoxia in primary human neural cells |
| 12050227 |
cyclooxygenase gene expression in human preimplantation embryos. |
| 11959891 |
Cyclooxygenase-2, player or spectator in cyclooxygenase-2 inhibitor-induced apoptosis in prostate cancer cells |
| 15756444 |
COX-2 has a role in response of esophageal squamous cell carcinoma to chemoradiotherapy |
| 15812311 |
under specific conditions of cellular stress, a common variation in cyclooxygenase-2 promoter structure may enhance cyclooxygenase-2 transcription, and this may contribute to the proliferation of an inflammatory response in brain cells |
| 11880271 |
in intestinal myofibroblasts, IL-1-mediated induction of COX-2 expression is a complex process that requires input from multiple signaling pathways. |
| 11972392 |
Cyclooxygenase-2 (COX-2), epidermal growth factor receptor (EGFR), and Her-2/neu are expressed in ovarian cancer. |
| 14517215 |
COX-2 induction by bradykinin in human pulmonary artery smooth muscle cells is mediated by the cyclic AMP response element through a novel autocrine loop involving endogenous prostaglandin E2, EP2 receptor, and EP4 receptor |
| 15968728 |
Augmented tumor neovascularization induced by VEGF may be one of the several effects of COX-2 responsible for poor prognosis of human gallbladder carcinoma |
| 16497971 |
a selective induction of cox-2 in multiple myeloma cells containing RAS mutations, results in heightened binding to extracellular matrix protein and chemotherapeutic drug resistance |
| 17006983 |
The -765G > C COX-2 polymorphism should be considered as another susceptibility marker for gastric adenocarcinoma development in patients with atrophy or intestinal metaplasia. |
| 17113084 |
COX-2 turnover appears to depend upon glycosylation of the 72kDa glycoform. |
| 17218407 |
Stretch of the amnion, on onset of labor, may contribute to increased expression of COX-2. |
| 12865795 |
potential involvement transplant rejection |
| 14726416 |
TXA2 produced by COX-2 plays an important role in megakaryocytopoiesis. |
| 15063780 |
We propose that a component of the cytokine-induced Cox-2 mRNA stabilization pathway is sensitive to acetylation. |
| 12397176 |
mediates the proliferative action of mast-cell tryptase: possible relevance to human fibrotic disorders |
| 14616542 |
Expression of Cox-2 is elevated in gastric adenocarcinomas, which correlates with several clinicopathological parameters, including depth of invasion and lymph node metastasis. |
| 15221958 |
Fibronectin stimulates human lung carcinoma cell proliferation and diminishes apoptosis by inducing COX-2 gene expression and PGE2 biosynthesis. |
| 15222024 |
iNOS and COX-2 may play a synergistic role in the pathogenesis of gastric MALT lymphoma. |
| 15222037 |
half of the cases expressed iNOS and COX-2, but these two enzymes do not seem to be the key step in angiogenesis or carcinogenesis of pancreatic adenocarcinomas. |
| 15272284 |
COX-2 expression was observed in 30 of the 68 tumor samples (44%). |
| 15319438 |
cyclooxygenase-2 expression is stimulated by endoplasmic reticulum stress through activation of NF-kappaB and pp38 mitogen-activated protein kinase |
| 16110762 |
there is higher stromal COX-2 mRNA expression compared to that within the epithelium for colorectal adenomas and carcinomas |
| 16111807 |
cyclooxygenase-2 elevation is related to lymph node metastasis in adenocarcinoma of uterine cervix |
| 16203768 |
histamine exerts both a proproliferative and a proangiogenic effect via H2/H4 receptor activation, mediated by increasing COX-2-related PGE2 production in COX-2-expressing colon cancer cells |
| 12349897 |
NFkappaB transcription factor is a key regulator of COX-2 expression in TNF-alpha-induced PGE2 production |
| 12391278 |
Cyclooxygenase-2 acts as an endogenous brake on endothelin-1 release by human pulmonary artery smooth muscle cells: implications for pulmonary hypertension. |
| 12767532 |
Orthotopic implantation of a colon cancer xenograft induces high expression of cyclooxygenase-2.COX-2 plays an important role in organ-specific liver metastasis of colon cancer. |
| 14729623 |
Expression of cyclooxygenase (COX)-2 is related to poor prognosis in ovarian carcinoma. |
| 16875891 |
Study suggests that COX-2 enzyme is important regulator of bone mineral density and bone strength. |
| 17507659 |
Identification of PSF, p54(nrb), PTB, and U1A as proteins specifically bound to the COX-2 polyadenylation signal upstream sequence elements . |
| 12444028 |
Induction of COX-2 may contribute to the inhibition of hypoxia-induced pulmonary vascular remodeling. |
| 12498388 |
The COX-2 expression in PC-3 High Invasive cells was approximately 3-fold higher than in PC-3 Low Invasive cells while the COX-1 expression was similar in both cell sublines. |
| 14501677 |
Over expression of COX-2 in reflux nephropathy suggests that COX-2 may be involved in the pathogenesis of tubulointerstitial damage associated with severe reflux nephropathy. |
| 15692221 |
Renal medullary oxygenation is improved by water diuresis in normal young women in a way that is blocked by a selective inhibitor of COX-2 as well as non-selective cyclooxygenase inhibitors. |
| 15800927 |
results suggest E1A-F is overexpressed in early stages of human CRC development and may be an important factor in the overexpression of COX-2 and MMP-7 |
| 15929167 |
Helicobacter pylori infection transactivates COX-2 promoter activity and increases the binding of NF-kappaB to this promoter. |
| 15929174 |
The demethylation of 5' CpG island of gene is necessary for COX-2 expression in human gastric cancer. |
| 15994313 |
Histone deacetylase inhibitors suppress the induction of c-Jun and its target genes including COX-2 |
| 16157291 |
Expression in kidney is a useful maker for tumorigenesis of the renal call carcinoma in vivo. |
| 16612568 |
Data show that substance P stimulates production of prostaglandin E2 and receptor activator of nuclear factor- B ligand, and promotes bone resorption. |
| 17265445 |
correlation between COX-2 and polo-like kinase-1 in a malignant prostate tumor |
| 12401798 |
PGE(2) production via a COX-2-catalyzed pathway plays a critical role in HIF-1alpha regulation by hypoxia; COX-2 inhibitors can prevent hypoxic induction of HIF-mediated gene transcription |
| 12777984 |
Cox-2 was established as a specific tumour marker for melanoma of potential interest for targeted therapeutics. |
| 14724276 |
COX-2-mediated cross-linking may inhibit Abeta catabolism and possibly generate toxic intracellular forms of oligomeric Abeta |
| 14966191 |
costimulatory effect of DEP & LPS led to enhanced production of COX-2 protein and to increased release of prostaglandin E(2); the effect was specific |
| 17264103 |
Analysis of gene expression demonstrated a significant elevation in expression of COX-1 and COX-2 mRNA in endometrium obtained from women with heavy MBL (menstrual blood loss) when compared with endometrium obtained from women with normal MBL. |
| 17459764 |
n-3 and n-6 polyunsaturated fatty acids increase PPARG activity is necessary for cyclooxygenase-2 induction in a human keratinocyte cell line. |
| 17536311 |
COX-2 is expressed at high levels in high grade osteosarcomas |
| 15550400 |
COX-2-positive prostate cancer cells can have impaired p53 function even in the presence of wild-type p53 and that p53 activity can be restored in these cells via inhibition of COX-2 activity. |
| 16203985 |
The COX-2-related pathway, which is essential in mediating cellular inflammatory response, is the critical signaling link for the bystander phenomenon. |
| 16273614 |
Allele 5209G was weakly associated with Crohn's disease (odds ratio (OR) 1.63, 95% confidence interval (CI) 1.03-2.57), and allele 8473T with ulcerative colitis (OR 1.50, 95%CI 1.00-2.27). |
| 16481301 |
Logistic regression analysis showed p53 and COX-2 as dependent predictors in pancreatic carcinogenesis, and a reciprocal relationship to neoplastic progression between p53 and COX-2. |
| 16675095 |
Vaginal administration of the nitric oxide donor isosorbide mononitrate (IMN) induces increased cervical expression of COX-2;this pathway may act in cervical ripening at term. |
| 16782382 |
study demonstrates that when cytomegalovirus replicates in retinal pigment epithelial cells, COX-2 induction augments virus replication via the PGE pathway |
| 16921134 |
Decreased PGI2S protein and mRNA in the lungs from patients with emphysema. |
| 17095859 |
The first evidence of the presence of COX-2 in mature neutrophils in bone marrow. Its expression varied with stage of differentiation. It may have a role in residual hematopoiesis in myelodysplastic marrow. |
| 17105783 |
COX-2 expression and mPGES-1 expression are co-ordinately up-regulated in lower segment myometrium with term labour. |
| 17341442 |
These data demonstrate that IGF-I induces COX-2 expression in human ovarian cancer cells, which is mediated by three parallel signaling cascades--PI3K, MAPK, and PKC pathways that differentially regulate COX-2 expression. |
| 17413988 |
In this test set, cyclooxygenase 2 and Caspase 3 seem to be immunohistochemical markers with prognostic significance for vulva cancer. |
| 17570496 |
data demonstrated that chronic inflammation appeared to play roles in induction of CCAAT/enhancer-binding protein beta expression in prostate epithelium which was associated with increased Cyclooxygenase-2 expression and androgen receptor downregulation |
| 12533667 |
The pathway of this enzyme is potentially involved in the regulation of tumor-associated angiogenesis and growth in pancreatic cancer |
| 12875991 |
Data describe the correlation between inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 activities and p53 gene status in head and neck squamous cell carcinomas in vivo and in vitro. |
| 14630807 |
p300 is the predominant coactivator that is essential for COX-2 transcriptional activation by proinflammatory mediators. |
| 14871981 |
COX-2 and mPGES-1 are overexpressed in squamous cell carcinoma of the penis |
| 15478052 |
Gene expression regulation plays a role in prognosis of ovarian carcinoma. |
| 11897504 |
the effects of several paracrine and/or autocrine signaling pathways in the regulation of expression of aromatase, COX-1, and COX-2 in breast cells has identified complex relationships |
| 15950941 |
Altogether our findings revealed that IL-20 is a negative modulator of COX-2/PGE(2) and inhibits angiogenesis. |
| 16393343 |
EP1 receptor level increase in sensory neurones, and macrophage infiltration, appears to precede increased Cox-2 expression by macrophages in nerve injuries |
| 11948128 |
In advanced gallbladder carcinoma, enhanced expression of cyclooxygenase-2 is observed in the adjacent stroma. |
| 12720297 |
COX-1 and COX-2 protein expression levels were determined in sets of tumor and normal colon tissue |
| 15000150 |
COX-2 has a role in colorectal tumorigenesis [review] |
| 15704107 |
COX-2 expression in both cancer cells and stromal cells within the lung cancer microenvironment may play an important role in upregulating the expression of the angiogenic factor VEGF in lung cancer. |
| 15334675 |
COX-2 expression induced by H pylori infection is a relatively early event during carcinogenesis in the stomach. |
| 15869467 |
The generation and antifungal activity of hydroxyeicosanoids from 3-HETE by COX-2 are reported. |
| 16323955 |
functional and physiological significance of COX-2 in the placenta and in fetal development. |
| 12881220 |
VEGF is one of the principal factors produced by hypoxic myocytes that is responsible for the induction of endothelial cell COX-2 expression. |
| 16820889 |
COX-2 is downregulated by PC-SPES via inhibition of NF-kappaB and C/EBPbeta in non-small cell lung cancer cells |
| 16930602 |
results suggest that COX-1 and COX-2 activities are decreased in the placental tissue of women with pre-eclampsia, probably by oxidative stress |
| 16950767 |
Lipopolysaccharide-induced up-regulation of COX-2 depends on the activity of the Mg(+2)-dependent phosphatidic acid phosphohydrolase 1 (PAP-1) |
| 17050069 |
Results suggest that irrespective of the underlying disease, lung injury that causes extensive fibrosis induces wide expression of COX-2 in the regenerating metaplastic epithelium. |
| 12748469 |
COX-2 expression is significantly more common in endometrial adenocarcinoma and ovarian serous cystadenocarcinoma, but not in cervical squamous carcinoma, compared with normal tissue. |
| 14566822 |
NO can be associated with carcinogenesis through the upregulation of COX-2 |
| 15754118 |
High cyclooxygenase-2 expression is associated with breast cancer |
| 15654517 |
gene expression regulation in Lyme disease |
| 15720413 |
Results showed a stepwise increase in the expression of COX-2 as mucosal damage progressed from normal to gastritis to gastric ulcer. |
| 15831295 |
Regulation of COX-2 may alter peritoneal healing and may provide the opportunity to reduce postoperative adhesion development. |
| 16473553 |
Expression of cyclooxygenase-2 enhances survival of chronic lymphocytic leukemia B cells. |
| 16786043 |
This effect is statistically significant in lung cancer stage I, suggesting that COX-2 expression could be useful at early stages to distinguish those with a worse prognosis. |
| 16984258 |
These studies suggest that SZ95 sebocytes express functional PAF-Rs and PAF-Rs are involved in regulating the expression of inflammatory mediators, including COX-2, PGE(2) and IL-8. |
| 12920574 |
association of a promoter variant in the inducible cyclooxygenase-2 gene (PTGS2) with type 2 diabetes mellitus in Pima Indians |
| 17418864 |
COX-2 expression in MCF10A breast epithelial cells confers a premalignant phenotype that includes enhanced genomic instability and altered cell-cycle regulation. |
| 12532440 |
Association of cyclooxygenase-2 expression with Hp-cagA infection in gastric cancer. |
| 12532441 |
Expression of cyclooxygenase-2 and clinicopathologic features in human gastric adenocarcinoma. Expression of COX-2 mRNA in gastric carcinoma was significantly higher. Staging classification was significantly correlated with COX-2 over-expression. |
| 15501771 |
expression in urethral epithelium upregulated by Neisseria gonorrhoeae PorB IB and upregulation dependent on NF-kappaB activation |
| 12743126 |
biochemical pathway exists wherein fluid shear activates cyclooxygenase-2, via a c-Jun N-terminal kinase2/c-Jun-dependent pathway, which in turn elicits downstream prostaglandin EP2 and EP3a1 receptor mRNA synthesis |
| 14747187 |
increased cyclooxygenase-2 expression in the endometriotic ovarian cyst wall was observed |
| 15816645 |
cyclooxygenase-2 enzyme expression differs in radiosensitive versus radioresistant glioblastoma multiforme cell lines |
| 12591723 |
Abnormal interleukin 10Ralpha expression contributes to the maintenance of elevated cyclooxygenase-2 in non-small cell lung cancer cells. |
| 12692419 |
Results suggest that expression of cyclooxygenase-2 is not correlated with clinicopathologic and biologic features of ampulla of Vater cancer. |
| 14607721 |
Overexpression of COX-2 plays crucial role in carcinogenesis and development of extra-hepatic cholangiocarcinoma, indicating that COX-2 may serve as target for chemoprevention of extra-hepatic cholangiocarcinoma. |
| 16681759 |
Increased cyclooxygenase-2 expression is correlated with suppressed antitumor immunity in cervical adenocarcinomas |
| 16699947 |
Forced COX-2 expression in gastric cancer cells did not inhibit apoptosis caused by NAG-1 expression. |
| 16314473 |
COX-2 overexpression likely represents an additional mechanism of resistance to apoptosis in B chronic lymphoid leukemia. |
| 17405913 |
H. pylori induces COX-2 expression, which is mediated by both activation and expression of PAR-2 in gastric epithelial cells |
| 12821125 |
COX-2 has a role in generating prostaglandin e2 which increases VEGF secretion in human pancreatic cancer |
| 14596920 |
sodium butyrate inhibits angiogenesis through down-regulation of COX-2 expression and prostaglandin (PG)E2 and PGI2 production |
| 14749287 |
Glucose-induced induction of COX-2 in human islets suggest that this is one route through which hyperglycemia may contribute to beta-cell dysfunction |
| 14989896 |
Cyclooxygenase-2 may be involved in the early stage of squamous carcinogenesis of the esophagus, and may be a target of prevention and treatment for esophageal squamous cell carcinoma. |
| 15010822 |
Up-regulation of cyclooxygenase 2 correlates with vascular endothelial growth factor expression and tumor angiogenesis in HBV-associated hepatocellular carcinoma |
| 15190260 |
COX1, but not COX2, is induced during ATRA-dependent maturation and appears to contribute to myeloid differentiation both in vitro and ex vivo, and COX-1 activity may potentiate the differentiation of human acute promyelocytic leukemia |
| 15673847 |
Noncoplanar PCBs alter HL-60 cell function and COX-2 expression via an Ah-receptor-independent mechanism. |
| 15804367 |
Atorvastatin down-regulates LPS-induced expression of the COX-2 and consequently inhibits production of PGE2 in cultured A549 cells. |
| 11847219 |
Up-regulation of prostaglandin E2 synthesis by interleukin-1beta in human orbital fibroblasts involves coordinate induction of prostaglandin-endoperoxide H synthase-2 and glutathione-dependent prostaglandin E2 synthase expression |
| 12070598 |
Cox-2 could participate in the carcinogenic process of oral mucosa |
| 16361272 |
a common PTGS2 variant increases bile duct cancer risk |
| 14669280 |
Increase in Cox-2 expression is correlated with the loss of epithelial basement membrane in morphologically normal areas |
| 12324457 |
mediation by NF-kappa B and Ku70 or Ku80 |
| 12679908 |
There is a correlation between expression of cyclooxygenase-2 and angiogenesis in human gastric adenocarcinoma. |
| 15146435 |
Basic calcium phosphate crystals may be an important amplifier of PGE(2) production through induction of the COX enzymes and the proinflammatory cytokine IL-1beta. |
| 15375804 |
Review of COX-2 expression in squamous cell head and neck neoplasms. |
| 15375805 |
Review of COX-2 in lung cancer treatment. COX-2 plays a role in lung cancer and may be a marker of prognosis. |
| 15767259 |
The main signaling pathway for toxin A induction of human COX-2 involves ROS-mediated activation of p38 MAPK, MSK-1, CREB, and ATF-1 |
| 15867220 |
Findings suggest that COX-2 may be an effective therapeutic target in prostate cancer treatment. |
| 16010419 |
Expression of COX2 is common in advanced urinary bladder cancer (BC) with poor prognostic characteristics, supporting efforts to initiate clinical trials on the efficacy of COX2 inhibitors in the adjuvant treatment of high-risk urinary BC. |
| 16076963 |
MMP-1 expression by latanoprost requires prior up-regulation of COX-2 |
| 16331686 |
Findings disclose a cross-talk between the COX-2/PGE(2)/EP(1) and EGFR/c-Met signaling pathways that coordinately regulate human hepatocellular carcinoma cell invasion. |
| 16357062 |
These results suggest that HRG might be a new member of the growth factor family involved in the COX-2-dependent ulcer repair process. |
| 16399783 |
CCAAT/enhancer-binding protein beta (C/EBPbeta) DNA-binding sites are crucial for the function of the COX-2 gene promoter. |
| 16632868 |
COX-2 and 15-PGDH are regulated reciprocally in A549 cells |
| 17171651 |
Possible influence of the COX-2 C8473T SNP in Parkinson's disease, although it only seems to be of importance in men. |
| 17404026 |
No association of COX-2 and inducible nitric oxide (NOS2) polymorphisms with cervical cancer is found in Korean women. |
| 17404027 |
Vulvar cancer in elderly patients may be associated with inflammation, and thus with increased COX-2 expression. |
| 12450219 |
COX-2 influences APP processing and promotes amyloidosis in the brain |
| 12462194 |
inducible nitric oxide synthase-cyclooxygenase 2 interactions are involved in tumor cell angiogenesis and migration |
| 12761889 |
regulation of expression by ATP |
| 14555963 |
cell-cell contacts induce an actively programmed necrotic process that functionally involves COX-2, a known hallmark of inflammation and cancer |
| 12701770 |
activation may be one of the distinct host degradative pathways in the pathogenesis of microbial-induced pulpal/periapical inflammation |
| 14511332 |
COX-2 expression was dramatically increased in the spinal cord of patients with ALS. |
| 16868662 |
These results implicate COX-2 in the angiogenesis and biological aggressiveness of diffuse astrocytomas. |
| 11850206 |
Aromatase and COX-2 expression in human breast cancers. |
| 11913955 |
Reduced prostate cancer growth after exposure to saw palmetto extract may relate to decreased expression of Cox-2 |
| 12162677 |
expression in pancreatic adenocarcinoma and pancreatic intraepithelial neoplasia |
| 11901151 |
overexpresssion in HER-2 positive breast cancer with involvement of AP-1 and PEA3 |
| 12664576 |
Activity is modulated in colorectal carcinoma cells. |
| 12684668 |
hypermethylation of the CpG island in the cox-2 gene is a major mechanism that mediates transcriptional silencing in a subset of gastric cancers |
| 12821538 |
COX-2 is induced in retinal astrocytes in human diabetic retinopathy, in the murine and rat model of ischemic proliferative retinopathy in vivo, and in hypoxic astrocytes in vitro. COX-2 but not COX-1 inhibitors prevented intravitreal neovascularization |
| 14535998 |
H. pylori LPS is of low biological activity when compared with E. coli LPS in its ability to induce the expression of cyclooxygenase 2 and synthesis of prostaglandin E2 |
| 14645117 |
cross-linking of the RelA subunit of NF-kappa B but not C/EBP beta to the cox-2 promoter and flanking sequences after IL-1 treatment |
| 14702352 |
COX-2-dependent prostanoids may play an important role in the regulation of hypoxia-induced Ang2 expression |
| 14769824 |
COX2 and some prostanoids play a key role in IL-1beta-induced angiogenesis |
| 14748725 |
Studies with the COX-2-selective inhibitor NS-398 confirmed the COX-2 dependency of the later increase in prostanoid production |
| 15138244 |
We found that the -765G-->C polymorphism of the COX-2 gene is associated with a decreased risk of MI and stroke. |
| 15246970 |
COX-2 plays a key role in VEGF production in gastric fibroblasts stimulated by IL-1 in vitro, and angiogenesis induced by the COX-2-VEGF pathway might be involved in gastric ulcer healing. |
| 15100359 |
renovascular COX-2 expression was a constitutive feature encountered in human kidneys at all ages, whereas COX-2 was seen in macula densa only in fetal kidney. |
| 15231484 |
Acid-induced activation of both ERK and p38 causes a significant increase in COX-2 promoter activity, and acid-activated ERK stabilizes COX-2 mRNA in Barrett's esophagus |
| 15653566 |
high glucose, via PI3K/Akt signaling, induces NF-kappaB-related upregulation of COX-2, which in turn triggers the caspase-3 activity that facilitates vascular endothelium apoptosis |
| 15789615 |
PGH synthase-2, CYP4F8, and PGE synthase-1 likely forms 19-hydroxy-PGE compounds in seminal vesicles and vas deferens |
| 11911965 |
Overexpression of cyclooxygenase-2 (COX-2) in human primitive neuroectodermal tumors |
| 15896711 |
These results suggested that the combination of 5-FU and genistein exert a novel chemotherapeutic effect in colon cancers, and AMPK may be a regulatory molecule of COX-2 expression, further implying its involvement in cytotoxicity caused by genistein. |
| 15921850 |
Elevated expression of cyclooxygenase-2 in colorectal adenocarcinoma is associated with p53 accumulation and hdm2 overexpression |
| 15963597 |
novel anti-inflammatory property of recombinant HBsAg which involves inhibition of COX-2. |
| 12205039 |
Protein kinase C-epsilon mediates bradykinin-induced cyclooxygenase-2 expression in human airway smooth muscle cells |
| 12698187 |
COX-2 upregulation contributes to oesophageal squamous carcinogenesis in head and neck cancer patients. |
| 12885872 |
Data suggest that TIA-1 functions as a translational silencer of cyclooxygenase-2 (COX-2) expression and support the hypothesis that dysregulated RNA-binding of TIA-1 promotes COX-2 expression in neoplasia. |
| 14534699 |
COX-2 expression is down-regulated in cervical and vulvar tumor cells invading the regional lymph nodes with respect to primary tumors |
| 15872218 |
Alternative polyadenylation of COX-2 may be an important post-transcriptional regulatory event. |
| 15919917 |
data indicate that hepatitis C virus core suppresses IKK signalsome activity, which blunts COX-2 expression in macrophages |
| 16044148 |
The loss of TNF-alpha-regulated COX-2 expression in ovarian neoplasms is associated closely with epithelial neoplastic morphological transformation. |
| 16278387 |
Cyclooxygenase-2-dependent activation of STAT3 by interleukin-6 has a role in non-small cell lung cancer |
|
