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KIAA1303


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Gene DB Home
Symbol:KIAA1303
Name(s):raptor
Type:protein-coding
Organism:Homo sapiens
Synonyms:-
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17656678 Proarteriosclerotic effects of interferon gamma are associated with mammalian target of rapamycin raptor complex (mTORC1) and PI-3 kinase activiation.
17329400 ASCT2 silencing inhibits mTORC1 (mTOR/raptor) signaling and leads to growth repression, followed by enhanced survival signaling via mTORC2 (mTOR/rictor) and apoptosis of hepatoma cells.
12150925 Raptor is a missing component of the mTOR pathway that through its association with mTOR regulates cell size in response to nutrient levels
12150926 raptor is an essential scaffold for the mTOR-catalyzed phosphorylation of 4EBP1 and mediates TOR action in vivo.
16914728 These studies suggest that, through serine phosphorylation, Raptor-mTOR and S6K1 promote the depletion of IRS1 from specific intracellular pools in pathological states of insulin and IGF-I resistance and in lesions associated with tuberous sclerosis.
16354680 Raptor directly binds to and serves as a scaffold for mTOR-mediated phosphorylation of IRS-1 on Ser636/639.
16959881 These data suggest that, during HCMV infection, the rictor- and raptor-containing complexes are modified such that their substrate specificities and rapamycin sensitivities are altered.
12604610 raptor binds to p70S6k and 4E-BP1 through their respective TOS (conserved TOR signaling) motifs.
16183647 A redox-sensitive mechanism regulates the phosphorylation of the raptor-mTOR effector S6K1, the interaction between raptor and mTOR, and the kinase activity of the raptor-mTOR complex.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDFK506 binding protein 12-rapamycin associated protein 1raptor--Pubmed
HPRDFK506 binding protein 12-rapamycin associated protein 1raptor--Pubmed
BINDFK506 binding protein 12-rapamycin associated protein 1raptormTOR interacts with raptor.-Pubmed
BINDRas homolog enriched in brainraptorRaptor interacts with Rheb.-Pubmed

Clinical Trials:

Clinical Trials Logo
Early Versus Interval Appendectomy for Ruptured Appendicitis in Children

Patents:

Patents logo
US Patent No.Title
7547687 Therapeutic treatment methods
7482334 Therapeutic treatment methods

KIAA1303 results (if any) from reagent suppliers

Google CSE Logo
Raptor Antibody Bethyl Laboratories
Alternate Names, Raptor, regulatory associated protein of mTOR; p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats, KIAA1303. ...
http://www.bethyl.com/go/?product/A300-506A...

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Phospho-Raptor-S863 Antibody
Regulatory-associated protein of mTOR; Raptor; P150 target of rapamycin (TOR)- scaffold protein; KIAA1303. Application Data: Calculated MW: 149038 Da ...
http://www.abgent.com/products/catalog_no/AP3495a_Phospho_Ra...

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Raptor (10E10) Antibody sc-81537
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, KIAA1303, 57521, 17q25.3, NM_020761
...
http://www.scbt.com/datasheet-81537-raptor-10e10-antibody.ht...

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CompoZr™ Knockout ZFN Kits
CKOZFN1034, CompoZr™ Knockout ZFN Kit human KIAA1303 (NM_020761) New, human ... KIAA1303(57521), pricing. CKOZFN1035, CompoZr™ Knockout ZFN Kit human LRP1 ...
http://www.sigmaaldrich.com/life-science/functional-genomics...

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Raptor Antibody / Raptor Antibodies
제품명, 카탈로그 번호, ISOTYPE, EPITOPE, APPLICATIONS, SPECIES. Raptor (10E10) Antibody, sc-81537, mouse IgG1, FL (h), WB, IP, m, r, h, dog ...
http://www.scbt.com/ko/table-raptor.html...

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Interferon (IFN)
AKT1 · IFNA · KIAA1303 (raptor), PIK3R1 (p85). AKT2 · IFNA1 · MAP2K3 (MEK3), PRKCA · AKT3 · IFNA2 · MAP2K6 (MEK6), PRKCD ...
http://www.invitrogen.com/site/us/en/home/Products-and-Servi...

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Raptor (10E10) Antibody sc-81537
... Locus cromosoma, Isoform (mRNA) Accession #, codice accesso proteina, Numero d' ordine. Human, KIAA1303, 57521, 17q25.3, NM_020761 · Q8N122 ...
http://www.scbt.com/it/datasheet-81537-raptor-10e10-antibody...

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