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PTN
| Symbol: | PTN | | Name(s): | pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | HARP, HBGF8, HBNF, NEGF1 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17881084 |
HARP negatively affects diverse biological activities in C6 glioma cells, mainly due to binding of HARP to VEGF, which may sequester secreted VEGF from signalling through VEGFR2. |
| 17823238 |
An autologous PTN-pleiotrophin receptor (PTPRZ1) signaling loop is present in human embryonic stem cells and functions here predominantly via an antiapoptotic effect. |
| 17925408 |
pleiotrophin potentiates cardiomyocyte cell death, at least partially, through inhibition of AKT signaling |
| 17578909 |
secretion of PTN through stimulation of the stromal cell microenvironment alone may be sufficient to account for significant features of breast cancer progression. |
| 17727841 |
identified the exact molecular domain involved in inhibition of HARP-induced mitogenesis |
| 17904822 |
Pleiotrophin failed to activate anaplastic lymphoma kinase (ALK) in neuroblastoma/glioblastoma cells expressing this receptor. ALK is still an orphan receptor in vertebrates. |
| 17908800 |
MMP-2 processing of HARP and CTGF released vascular endothelial growth factor (VEGF) from angiogenic inhibitory complexes. |
| 17607711 |
Inhibition of the mitogenic, angiogenic, and tumorigenic activities of PTN by a synthetic peptide corresponding to its C-thrombospondin repeat-I domain. |
| 17681947 |
phosphorylation of ALK in PTN-stimulated cells is mediated through the PTN/RPTPbeta/zeta signaling pathway |
| 17443289 |
PTN expression is associated with histopathological grade of astrocytomas | →View more information from publications. |
Recent Publications on PTN: |  |
PTP4A3 expression increases strongly in lymph node metastases from colorectal carcinoma.
BACKGROUND: Numerous studies have proven that protein tyrosine phosphatase... | 23rd October, 2009
| Department of General Pathomorphology, Medical University of Bialystok,
| Anticancer Res. 2009 Oct;29(10):3913-6.
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Pleiotrophin induces neurite outgrowth and up-regulates growth-associated protein (GAP)-43 mRNA through the ALK/GSK3beta/beta-catenin signaling in developing mouse neurons.
Pleiotrophin (PTN) is highly expressed in the nervous system during... | 17th October, 2009
| Department of Developmental Morphology, Tokyo Metropolitan Institute for
| Neurosci Res. 2009 Oct 13.
DOI Direct Link |
In vivo protein tyrosine nitration in S. cerevisiae: identification of tyrosine-nitrated proteins in mitochondria.
Protein tyrosine nitration (PTN) is a selective post-translational... | 14th October, 2009
| Department of Biochemistry, University College of Science, University of
| Biochem Biophys Res Commun. 2009 Oct 23;388(3):612-7. Epub 2009 Aug 18.
DOI Direct Link |
Effect of single-chain antibody targeting of the ligand-binding domain in the anaplastic lymphoma kinase receptor.
The tyrosine kinase receptor anaplastic lymphoma kinase (ALK) and its... | 9th October, 2009
| Lombardi Cancer Center, Georgetown University, Washington, DC 20057, USA.
| Oncogene. 2009 Sep 17;28(37):3296-306. Epub 2009 Jul 27.
DOI Direct Link |
Does prematurity affect platelet indices?
Purpose: The current study objective was to compare blood platelet indices... | 8th October, 2009
| Department of Neonatology, Medical University of Bialystok, Bialystok,
| Adv Med Sci. 2009 Oct 6:1-3.
DOI Direct Link |
→View more research publications. |
Press Releases on PTN:
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| Palatin Technologies, Inc. Reports First Quarter Fiscal Year 2010 Results; Teleconference and Webcast to be held on November 16, 2009 |
16th November, 2009 |
Palatin Technologies, Inc. |
CRANBURY, N.J., Nov. 16 /PRNewswire-FirstCall/ -- Palatin Technologies, Inc. (NYSE Amex: PTN) today announced results for its quarter ended September 30, 2009. Palatin reported a net
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| Palatin Technologies, Inc. To Report Fiscal Year 2010 First Quarter Results; Teleconference and Webcast to be held on November 16, 2009 |
12th November, 2009 |
Palatin Technologies, Inc. |
CRANBURY, N.J., Nov. 12 /PRNewswire-FirstCall/ -- Palatin Technologies, Inc. (NYSE Amex: PTN) will announce its first quarter, fiscal year 2010 financial results on Monday, November 16, 2009
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| Palatin Technologies to Present at 8th Annual BIO Investor Forum |
28th October, 2009 |
Palatin Technologies, Inc. |
CRANBURY, N.J., Oct. 28 /PRNewswire-FirstCall/ -- Palatin Technologies, Inc. (NYSE Amex: PTN) announced that it will be presenting at the 2009 BIO Investor Forum on Thursday, October 29, 2009
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| Palatin Technologies to Receive $5 Million from AstraZeneca |
29th September, 2009 |
Palatin Technologies, Inc. |
CRANBURY, N.J., Sept. 29 /PRNewswire-FirstCall/ -- Palatin Technologies, Inc. (NYSE Amex: PTN) today announced that it will receive $5 million from AstraZeneca relating to an amendment of
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| Palatin Technologies, Inc. Reports Fiscal Year 2009 Third Quarter Results; Teleconference and Webcast to be held on May 15, 2009 |
15th May, 2009 |
Palatin Technologies, Inc. |
CRANBURY, N.J., May 15 /PRNewswire-FirstCall/ -- Palatin Technologies, Inc. (NYSE Amex: PTN) announced today results for its third quarter ended March 31, 2009. Palatin reported net income of
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PTN results (if any) from reagent suppliers | 
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