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PTPN1


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Gene DB Home
Symbol:PTPN1
Name(s):protein tyrosine phosphatase, non-receptor type 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:PTP1B
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18253097 It may be possible to increase proliferative activity of human corneal endothelial cells, particularly in cells from older donors, by inhibiting the activity of this important protein tyrosine phosphatase.
11756316 Observational study of gene-disease association. (HuGE Navigator)
11836311 Observational study of genotype prevalence and gene-disease association. (HuGE Navigator)
15097232 Observational study of gene-disease association. (HuGE Navigator)
15189365 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
15235769 Observational study of gene-disease association. (HuGE Navigator)
15504984 Observational study of gene-disease association. (HuGE Navigator)
15504985 Observational study of gene-disease association. (HuGE Navigator)
15715684 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
15919813 Observational study of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDserine/threonine protein kinaseprotein tyrosine phosphatase, non-receptor type 1--Pubmed
HPRDcaveolin 1PTPN1--Pubmed
BINDcaveolin 1protein tyrosine phosphatase, non-receptor type 1caveolin-1 interacts with PTP1B.-Pubmed
HPRDcadherin 2, type 1 preproproteinPTPN1--Pubmed
HPRDcatenin, beta 1, 88kDaPTPN1--Pubmed
HPRDepidermal growth factor receptor oncogene homolog, avian)PTPN1--Pubmed
HPRDgrowth factor receptor-bound protein 2 isoform 1protein tyrosine phosphatase, non-receptor type 1--Pubmed
HPRDglycogen synthase kinase 3 betaPTPN1--Pubmed
HPRDinsulin-like growth factor 1 receptor precursorprotein tyrosine phosphatase, non-receptor type 1--Pubmed
HPRDinsulin receptorprotein tyrosine phosphatase, non-receptor type 1--Pubmed

Recent Publications on PTPN1:

Pubmed Logo
An integrated approach for experimental target identification of hypoxia-induced miR-210.
miR-210 is a key player of cell response to hypoxia, modulating cell...
15th October, 2009
IRCCS-Policlinico San Donato, San Donato Milanese, Milan., Italy; J Biol Chem. 2009 Oct 13.
DOI Direct Link
Sphingosine 1-phosphate increases glucose uptake through trans-activation of insulin receptor.
Sphingosine 1-phosphate (S1P) is a bioactive lipid that acts through a...
10th October, 2009
Department of Biochemical Sciences, University of Florence, Viale G.B. Cell Mol Life Sci. 2009 Oct;66(19):3207-18. Epub 2009 Aug 7.
DOI Direct Link
Design and synthesis of 3,5-diarylisoxazole derivatives as novel class of anti-hyperglycemic and lipid lowering agents.
We have designed 1,3-disubstituted-5-membered heteroaromatic ring system...
9th October, 2009
Medicinal and Process Chemistry Division, Central Drug Research Institute, Bioorg Med Chem. 2009 Jul 15;17(14):5285-92. Epub 2009 May 18.
DOI Direct Link
Characterization of novel oxidation products of cysteine in an active site motif peptide of PTP1B.
We investigated the formation of hydroxyl radical (OH(*)) and H(2)O(2)...
7th October, 2009
Kimmel Center for Biology and Medicine at the Skirball Institute and J Am Soc Mass Spectrom. 2009 Aug;20(8):1540-8. Epub 2009 May 4.
DOI Direct Link
Protein tyrosine phosphatase 1B, a major regulator of leptin-mediated control of cardiovascular function.
BACKGROUND: Obesity causes hypertension and sympathoactivation, a process...
24th September, 2009
Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, Circulation. 2009 Sep 1;120(9):753-63. Epub 2009 Aug 17.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
5801021 Amplifications of chromosomal region 20q13 as a prognostic indicator in breast cancer
6808878 Genes from the 20Q13 amplicon and their uses
6872533 STK15 (STK6) gene polymorphism and methods of determining cancer risk
6905827 Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
6936417 Gene expression in bladder tumors

View more patents.

PTPN1 results (if any) from reagent suppliers

Google CSE Logo
non-receptor type 1 protein tyrosine phosphatase (PTPN1 - Orbigen ...
Non-receptor type 1 protein tyrosine phosphatase (PTPN1) is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and ...
http://www.orbigen.com/commerce/catalog/product.jsp?product_...

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PTP1B/PTPN1, active-Echelon Biosciences Inc.
PTP1B/PTPN1 is protein tyrosine phosphatase, non-receptor type 1. Recombinant human catalytic domain (amino acids 1-321) of PTP1B with N-terminal GST tag ...
http://www.echelon-inc.com/ccp1809-ptp1b-ptpn1--active-e-p00...

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Recombinant PTP1B (1–321)/PTPN1 Active Enzyme
know as Protein-tyrosine phosphatase 1B, PTPN1 is a PTP. (protein tyrosine phosphatase) first isolated from human placenta. ...
http://www.exalpha.com/pdfs/X1659E.pdf...

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non-receptor type 1 protein tyrosine phosphatase (PTPN1 - Orbigen ...
PTP1B (PTPN1)is a non-receptor type 1 protein tyrosine phosphatase and the founding member of the protein tyrosine phosphatase (PTP) family, ...
http://www.orbigen.com/commerce/catalog/product.jsp?product_...

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PTP1B Antibody Bethyl Laboratories
Alternative names for PTPN1 include protein tyrosine phosphatases non-receptor type 1, PTPN1, and PTP-1B. [taken from NCBI GeneID:5770] ...
http://www.bethyl.com/go/?product/A302-297A...

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Phosphatases
non-receptor type 1 protein tyrosine phosphatase (PTPN1) polyclonal antibody ... tyrosine phosphatase non-receptor type 1 (PTPN1) polyclonal antibody ...
http://www.orbigen.com/dictionary/cat1055.htm...

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PTP1B (H-135) Antibody sc-14021
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, PTPN1, 5770, 20q13.13, NM_002827 ...
http://www.scbt.com/datasheet-14021-ptp1b-h-135-antibody.htm...

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