|
| |
PTPN6
| Symbol: | PTPN6 | | Name(s): | protein tyrosine phosphatase, non-receptor type 6 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
|
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18209728 |
Mononuclear leukocytes of multiple sclerosis patients have a deficiency in SHP-1 and increased inflammatory gene expression. |
| 18174230 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17561098 |
SHP-1 and SHP-2, two structurally related cytoplasmic protein-tyrosine phosphatases with different cellular functions and cell-specific expression patterns, were compared for their intrinsic susceptibility to oxidation by H(2)O(2). |
| 17142110 |
increased activity of inhibitory molecules, such as Src homology domain-containing protein tyrosine phosphatase-1 (SHP-1) and suppressors of cytokine signalling (SOCS), is responsible for age-related failure of GM-CSF to stimulate neutrophil functions |
| 17218319 |
findings provide an insight into the structure of the hematopoietic cell-specific P2 promoter of the SHP-1 gene and identify PU.1 as the transcriptional activator of the P2 promoter |
| 14976049 |
hypermethylated in multiple myeloma |
| 15070900 |
SHP-1 can dephosphorylate alpha-actinin in vitro and in vivo. |
| 12917349 |
Vav1 trapping was independent of actin polymerization, suggesting that inhibition of cellular cytotoxicity occurs through an early dephosphorylation of Vav1 by SHP-1, which blocks actin-dependent activation signals. |
| 12591278 |
show the existence of multiple transcripts of SHP-1 in human transformed T cells and normal PBMCs and give evidence supporting the concept that SHP-1 can negatively regulate growth of malignant T cells |
| 15870198 |
STAT3 may transform cells by inducing epigenetic silencing of SHP-1 in cooperation with DNMT1 and histone deacetylase 1 | →View more information from publications. |
Recent Publications on PTPN6: |  |
Siglec-9 and SHP-1 are differentially expressed in neonatal and adult neutrophils.
Neonatal PMN (polymorphonuclear neutrophils) exhibit altered inflammatory... | 29th October, 2009
| Department of Pediatrics, Saint Louis University School of Medicine, St.
| Pediatr Res. 2009 Sep;66(3):266-71.
DOI Direct Link |
DNA methylation regulates constitutive expression of Stat6 regulatory genes SOCS-1 and SHP-1 in colon cancer cells.
PURPOSE: Stat6 signaling is active in cancer cells and IL-4-induced Stat6... | 9th October, 2009
| Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University
| J Cancer Res Clin Oncol. 2009 Dec;135(12):1791-8. Epub 2009 Jun 24.
DOI Direct Link |
Pivotal advance: CEACAM1 is a negative coreceptor for the B cell receptor and promotes CD19-mediated adhesion of B cells in a PI3K-dependent manner.
Upon antigen binding, the BCR transduces a signal culminating in... | 3rd September, 2009
| Division of Immunology, Beckman Research Institute at City of Hope,
| J Leukoc Biol. 2009 Aug;86(2):205-18. Epub 2009 May 19.
DOI Direct Link |
Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5.
Given its catalytic activity to generate diacylglycerol and inositol... | 22nd August, 2009
| Division of Cell Biology, La Jolla Institute for Allergy and Immunology,
| Cancer Cell. 2009 Aug 4;16(2):161-71.
DOI Direct Link |
The SPS affair: a complex tale of illicit proliferation.
In this issue of Cancer Cell, Xiao et al. report that PLC-beta3 mutant... | 22nd August, 2009
| Department of Pediatrics, Helen Diller Family Comprehensive Cancer Center,
| Cancer Cell. 2009 Aug 4;16(2):87-8.
DOI Direct Link |
→View more research publications. |
PTPN6 results (if any) from reagent suppliers | 
|
CKOZFN1061 CompoZr™ Knockout ZFN Kit human PTPN6 (NM_002831)
CKOZFN1061 CompoZr Knockout ZFN Kit human PTPN6 (NM_002831) CompoZr Knockout ZFNs create targeted double strand breaks at a gene specific target locus.
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...
|
 |
EPO receptor antibody, EPO receptor Antibody, Goat Polyclonal Antibody
The N-terminal SH2 domain of PTPN6 binds Tyr-454 and inhibits signaling through ... Phosphorylation on Tyr-454 is required for PTPN6 interaction, ...
http://www.genwaybio.com/product_info.php?products_id=195181...
|
 |
Abgent Antibodies and Peptides
AP7998a, MAPKAPK3 Antibody (N-term), WB, E, H, 2009-10-28. AP2811b, PTPN6 Antibody (C-term), WB, E, H, 2009-10-28. AP7254a, CDK7 Antibody (N-term K42) ...
http://www.abgent.com/products/new_release...
|
 |
SH-PTP1 (D-11) Antibody sc-7289
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, PTPN6, 5777, 12p13.31, NM_002831, ...
http://www.scbt.com/datasheet-7289-sh-ptp1-d-11-antibody.htm...
|
 |
Monoclonal Anti-SHP-1 antibody produced in mouse (S8315) - Datasheet
SH2-containing tyrosine phosphatase (PTPN6). Genomics, 13, 869-872 (1992). ... splicing of hematopoietic cell phosphatase (PTPN6). ProductInformation ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...
|
 |
Abgent - Stem Cell
AP2827bNEW, PTGS1 Antibody (C-term), WB, IHC, E, H. AP2811bNEW, PTPN6 Antibody ( C-term), WB, E, H. AP2811cNEW, PTPN6 Antibody (Center), WB, IHC, E, H ...
http://www.abgent.com/products/category/stem_cell...
|
 |
SSTR2 (H-50) Antibody sc-25676
Tumoral prostate shows different expression pattern of somatostatin receptor 2 ( SSTR2) and phosphotyrosine phosphatase SHP-1 (PTPN6) according to tumor ...
http://www.scbt.com/datasheet-25676-sstr2-h-50-antibody.html...
|
 |
Search Bioportfolio and other Life Science Sites for PTPN6,
or search for PTPN6 on BioPortfolio's antibody search engine.
This page has been viewed 295 times
Recent Search Terms used to find this page: protein tyrosine phosphatase non-receptor type 6 isoform 1 | protein tyrosine phosphatase, non-receptor type 6 isomform 1 | chromosomal location of ptpn6 | epigenetic protein tyrosine phosphatase 2009 | gene location neutrophilic tyrosine kinase receptor type 3 | protein tyrosine phosphatase receptor type sigma isoform 3 precursor | Protein tyrosine phosphatase non-receptor type 6 | PTPN6 protein | ptpn4 neutrophil | .
Resources from the NCBI used on this page, NCBI's standard disclaimer applies.
|
