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BAK1


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Symbol:BAK1
Name(s):BCL2-antagonist/killer 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:BAK, BAK-LIKE, BCL2L7, CDN1, MGC117255, MGC3887
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17724463 Bak-positive cells showed an increased sensitivity to apoptosis induction by staurosporine.
16988840 Observational study of gene-disease association. (HuGE Navigator)
17991745 Galpha(s) protects neuroblastoma cells from hydrogen peroxide-induced apoptosis by repressing Bak induction.
17686864 FPV039 is a functional Bcl-2 homologue that inhibits apoptosis by neutralizing the proapoptotic Bcl-2 family member Bak.
18056640 transfection of synthetic miR-125b stimulated androgen-independent growth of Cprostate cancer cells and down-regulated the expression of Bak1
17880809 We conclude that alteration in the expression of proapoptotic (Bax, Bak) and antiapoptotic (Bcl-2, Bcl-XL) proteins on surface of thyroid follicular cells may play a role in the pathogenesis of thyroid autoimmune disorders.
17698840 Mcl-1 confers TRAIL resistance by serving as a buffer for Bak, Bim, and Puma, and sorafenib is a potential modulator of TRAIL sensitivity
17699158 Bcl-x(L) interacts with the DNA binding site of p53, but Bak does not interact with this site
17015472 inhibiting the fission machinery in Bax/Bak-mediated apoptosis, by down-regulating of Drp1 or hFis1, prevents the fragmentation of the mitochondrial network
15248898 Overexpression of the BAK gene can lead to apoptosis of gastric cancer cells in vitro, which does not appear to be dependent on p53 status.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDBCL2 antagonist killer 1Homo sapiens porin mRNA, and translated products--Pubmed
HPRDBCL2 antagonist killer 1BH3 interacting domain death agonist isoform 2--Pubmed
HPRDBCL2 antagonist killer 1chaperonin--Pubmed
HPRDBCL2 antagonist killer 1BCL2-related protein A1 isoform 1--Pubmed
HPRDBCL2-antagonist/killer 1BCL2 related protein A1--Pubmed
HPRDBCL2-antagonist/killer 1Heat shock 60 KD protein 1--Pubmed
HPRDBCL2-antagonist/killer 1VDAC2--Pubmed
BINDBCL2-antagonist/killer 1p53 transformation suppressorMitochondrial p53-P72 interacts with Bak.-Pubmed
BINDBCL2-antagonist/killer 1tumor protein p53Mitochondrial p53-R72 interacts with Bak.-Pubmed
HPRDBCL2-antagonist/killer 1B-cell lymphoma protein 2 alpha isoform--Pubmed

Recent Publications on BAK1:

Pubmed Logo
Response to: BAK1 gene variation and abdominal aortic aneurysms - variants are likely due to sequencing of a processed gene on chromosome 20.
We have identified two novel human genes homologous to BAI1...
23rd October, 2009
Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Hum Mutat. 2009 Oct 21.
DOI Direct Link
BAK1 gene variation and abdominal aortic aneurysms - variants are likely due to sequencing of a processed gene on chromosome 20.
We have identified two novel human genes homologous to BAI1...
23rd October, 2009
Department of Pathology, HSC-T8, Room 053, State University of New York, Hum Mutat. 2009 Oct 21.
DOI Direct Link
Requirement of voltage-dependent anion channel 2 for pro-apoptotic activity of Bax.
Mitochondrial membrane permeabilization is central to apoptotic signaling...
23rd October, 2009
Department of Medical Genetics, Osaka University Medical School, Suita, Oncogene. 2009 Oct 8;28(40):3563-72. Epub 2009 Jul 20.
DOI Direct Link
Regulation of cell death and innate immunity by two receptor-like kinases in Arabidopsis.
Upon recognition of bacterial flagellin, the plant receptor FLS2...
23rd October, 2009
College of Biological Sciences, China Agricultural University, Beijing Cell Host Microbe. 2009 Jul 23;6(1):34-44.
DOI Direct Link
Engineering OsBAK1 gene as a molecular tool to improve rice architecture for high yield.
Generating a new variety of plant with erect-leaf is a critical strategy...
22nd October, 2009
Research Center for Molecular & Developmental Biology, Key Laboratory of Plant Biotechnol J. 2009 Oct;7(8):791-806.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Study of Biomarkers in Blood and Bone Marrow Samples From Patients With Previously Untreated Chronic Lymphocytic Leukemia

Patents:

Patents logo
US Patent No.Title
4790637 Color-corrected catadioptric systems
6516116 High speed optical receiver
6584538 Information processing system
6586209 Xylanase production
6673908 Tumor necrosis factor receptor 2

View more patents.

BAK1 results (if any) from reagent suppliers

Google CSE Logo
Anti-BAK Polyclonal Antibody
PA1-9014 detects BAK1 in human samples. PA1-9014 has been successfully used in ... Figure 1 illustrates Western blot detection of BAK1 in A431 lysate using ...
http://www.bioreagents.com/products/productDetails/productDe...

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Bak (G-23) Antibody sc-832
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, BAK1, 578, 6p21.31, NM_001188 ...
http://www.scbt.com/datasheet-832-bak-g-23-antibody.html...

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BCL2 peptide, BCL-2 (Ab-56) Antibody Blocking Peptide peptide
BCL-2 (Ab-56) Antibody Blocking Peptide interacts with BAK1, IgG (GenWay Catalog #: 06-785-213274). BCL-2 (Ab-56) Antibody Blocking Peptide interacts with ...
http://www.genwaybio.com/product_info.php?products_id=213274...

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B5897 Anti-Bak antibody produced in rabbit IgG fraction of ...
... 1:100 using sections of human colon carcinoma. microarray: suitable. Gene Information, human ... BAK1(578). shipped in, dry ice. storage temp. −20°C ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=B589...

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MCL1 antibody, Induced myeloid leukemia cell differentiation ...
Isoform 1 interacts with BAX, BAK1, TPT1 and BCL2L11. Heterodimer of isoform 1 and isoform 2. Homodimers of isoform 1 or isoform 2 are not detected. ...
http://www.genwaybio.com/product_info.php?products_id=15230...

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Antibodies to Bcl-2 Family Proteins
WB, pricing. B5897, Anti-Bak antibody produced in rabbit, (polyclonal), IgG fraction of antiserum, human ... BAK1(578), human, ARR, IHC (p), WB, pricing ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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BAX antibody, Apoptosis regulator BAX, membrane isoform alpha ...
Apoptosis regulator BAX, membrane isoform alpha interacts with BAK1, IgG (GenWay Catalog #: 18-661-15197). Apoptosis regulator BAX, membrane isoform alpha ...
http://www.genwaybio.com/product_info.php?products_id=15197...

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