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BAX
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18034190 |
findings identify RelA/NF-kappaB as a critical regulator of T-cell survival by affecting the balance of Bcl-2 family members. |
| 18158779 |
Patients bearing bax positive/cytochrome c positive tumors have a decreased 4-year disease-free survival rate compared to the rest of the group. |
| 17997990 |
Translocation of Bax was essential for TIP30-induced apoptosis, whereas overexpression of the anti-apoptotic protein Bcl-xL delayed both second mitochondria-derived activator of caspases (Smac/DIABLO) release and onset of apoptosis. |
| 18023359 |
IL-10 modulated the pro-apoptotic capacity of TNF-alpha in chondrocytes as shown by the decrease in caspase activities and bax/bcl-2 ratio |
| 18211414 |
The low frequency of apoptotic phenomena (caspase-3 and Bax) in epithelial cells of oral lichen planus may create a favourable substrate for malignant transformation. |
| 17562177 |
Bcl-2 immunohistochemical profile may be useful in detecting adenomas with a malignant potential, and in combination with Dukes stage, may predict prognosis in colorectal cancer. |
| 17996028 |
critical involvement of p38 MAPK, PUMA, and Bax in 6-OHDA-induced apoptosis |
| 16215676 |
To evaluate the importance of Bax in apoptosis after photodynamic therapy (PDT), we compared the PDT responses of Bax-proficient (Bax(+/-)) and Bax knock-out (BaxKO) HCT116 human colon cancer cells. |
| 17668322 |
These results suggest that PKCepsilon mediates its effects on TNFalpha- based apoptosis partly by preventing activation and translocation of Bax to the mitochondria. |
| 18006502 |
Raf-1 in beta-cells led to a striking loss of Bad phosphorylation at serine 112 and an increase in the protein levels of both Bad and Bax | →View more information from publications. |
Recent Publications on BAX: |  |
Inhibitory role of cAMP on doxorubicin-induced apoptosis in pre-B ALL cells through dephosphorylation of p53 serine residues.
Exposure of cells to chemotherapeutic drug doxorubicin, a DNA-damaging... | 3rd November, 2009
| Department of Hematology, Faculty of Allied Medicine, Iran University of
| Apoptosis. 2009 Nov 1.
DOI Direct Link |
Cell Apoptosis Induced by delta-Elemene in Colorectal Adenocarcinoma Cells via a Mitochondrial-mediated Pathway.
The chemical compound delta-elemene, isolated from the Chinese herbal... | 3rd November, 2009
| The Sixth Affiliated Hospital, SUN YAT-SEN University.
| Yakugaku Zasshi. 2009 Nov;129(11):1403-13.
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Bax contains two functional mitochondrial targeting sequences and translocates to mitochondria in a conformational change- and homo-oligomerization-driven process.
The apoptosis gateway protein Bax normally exists in the cytosol as a... | 3rd November, 2009
| Univ. of Nebraska Medical Ctr., United States;
| J Biol Chem. 2009 Oct 30.
DOI Direct Link |
Honokiol induces cell apoptosis in human chondrosarcoma cells through mitochondrial dysfunction and endoplasmic reticulum stress.
Chondrosarcoma is a malignant primary bone tumor that responds poorly to... | 3rd November, 2009
| Institute of Toxicology, National Taiwan University, Taipei, Taiwan, ROC.
| Cancer Lett. 2009 Oct 30.
DOI Direct Link |
A novel Podophyllotoxin derivative (YB-1EPN) induces apoptosis and down-regulates express of P-gp in multidrug resistance cell line KBV200.
Our group synthesized a new potent antitumor podophyllotoxin derivative,... | 3rd November, 2009
| Medical College of Chinese People's Armed Police Forces; Tianjin 300162,
| Eur J Pharmacol. 2009 Oct 29.
DOI Direct Link |
→View more research publications. |
Press Releases on BAX:
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| Innocoll Announces Provisional Findings From Its Three Phase 2 Clinical Trials Investigating CollaRx(R) GENTAMICIN TOPICAL for the Treatment and Prevention of Diabetic Foot Infections |
18th June, 2009 |
Innocoll, Inc. |
ASHBURN, Va., June 18 /PRNewswire/ -- Innocoll, Inc., a privately-held biopharmaceutical company, announced positive provisional findings from its three phase 2 clinical trials sponsored by its
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| Baxter International Shareholders Meeting |
27th April, 2009 |
Baxter International Inc. |
DEERFIELD, Ill., April 27 /PRNewswire-FirstCall/ -- Baxter International (NYSE: BAX), will host its annual shareholders meeting on Tuesday, May 5, 2009, at 11:30 a.m. Eastern Time (10:30 a.m.
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| Baxter International First Quarter 2009 Financial Results Conference Call |
13th April, 2009 |
Baxter International |
DEERFIELD, Ill., April 13 /PRNewswire-FirstCall/ -- Baxter International (NYSE: BAX), will host a quarterly conference call to discuss its first quarter 2009 financial results on Thursday, April 16
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| Innocoll, Inc. Files 510 (k) Application for CollaRx Lidocaine Sponge |
31st March, 2009 |
Innocoll, Inc. |
ASHBURN, Va., March 31 /PRNewswire/ --- Innocoll, Inc. announced that its wholly-owned subsidiary, Innocoll Pharmaceuticals, has filed a US 510k application for its CollaRx(TM) Lidocaine Sponge for
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| Innocoll Announces Dosing of Last Patient in Second US Phase 3 Clinical Trial to Investigate GENTAMICIN SURGICAL IMPLANT for Prevention of Surgical Site Infections in Colorectal Surgery Patients |
19th March, 2009 |
Innocoll, Inc. |
ASHBURN, Va., March 19 /PRNewswire/ -- Innocoll, Inc., a privately-held biopharmaceutical company, announced that the last patient has been dosed in the second of two ongoing U.S. phase 3 clinical
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