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RAB4A
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 15689494 |
In contrast to Rab11, Rab4 is not involved in exocytosis |
| 15292453 |
Data suggest that abnormal membrane recycling in Niemann-Pick type A and C lipid storage disease fibroblasts results from specific inhibition of rab4 function by excess cholesterol in early endosomes. |
| 16413502 |
The study suggests that Rab4 regulates the channel through multiple mechanisms that include protein-protein interaction, GTP/GDP exchange, and channel protein trafficking. |
| 16389071 |
critical element that regulates epithelial sodium channel (ENaC) function by GTP-GDP recycling and concomitant changes in ENaC expression at the cell surface and in intracellular pool |
| 16926431 |
CT229 of Chlamydia trachomatis interacts with and recruits Rab4A to the inclusion membrane and therefore may play a role in regulating the intracellular trafficking or fusogenicity of the chlamydial inclusion. |
| 15907487 |
Rab4 specific residue His39 modulates the nucleotide binding pocket giving rise to a reduced rate for nucleotide hydrolysis and exchange |
| 16935861 |
Regulation of CD4 expression via recycling by HRES-1/RAB4 controls susceptibility to HIV infection |
| 11786538 |
Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein |
Recent Publications on RAB4A: |  |
Rab4b is a small GTPase involved in the control of the glucose transporter GLUT4 localization in adipocyte.
BACKGROUND: Endosomal small GTPases of the Rab family, among them Rab4a,... | 23rd September, 2009
| INSERM U895, Centre Mediterraneen de Medecine Moleculaire (C3M), Team 7,
| PLoS One. 2009 Apr 17;4(4):e5257.
DOI Direct Link |
Activation of protein kinase C alpha is necessary for sorting the PDGF beta-receptor to Rab4a-dependent recycling.
Previous studies showed that loss of the T-cell protein tyrosine... | 22nd September, 2009
| Ludwig Institute for Cancer Research, Uppsala University, Biomedical
| Mol Biol Cell. 2009 Jun;20(12):2856-63. Epub 2009 Apr 15.
DOI Direct Link |
VEGFR1 (Flt1) regulates Rab4 recycling to control fibronectin polymerization and endothelial vessel branching.
The cell's main receptor for VEGF, VEGFR2 (Kdr) is one of the most... | 24th March, 2009
| Beatson Institute for Cancer Research (Cancer Research UK), Garscube
| Traffic. 2009 Jun;10(6):754-66.
DOI Direct Link |
Recycling of the human prostacyclin receptor is regulated through a direct interaction with Rab11a GTPase.
The human prostacyclin receptor (hIP) undergoes agonist-induced... | 7th February, 2009
| UCD School of Biomolecular and Biomedical Sciences, UCD Conway Institute
| Cell Signal. 2008 Dec;20(12):2332-46. Epub 2008 Sep 7.
DOI Direct Link |
Substrate uptake and metabolism are preserved in hypertrophic caveolin-3 knockout hearts.
Caveolin-3 (Cav3), the primary protein component of caveolae in muscle... | 26th September, 2008
| Dept. of Cancer Biology, Thomas Jefferson Univ., 233 S. 10th St., BLSB
| Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H657-66. Epub 2008 Jun
DOI Direct Link |
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RAB4A results (if any) from reagent suppliers | 
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