Monday November 23 2009 | Biotechnology feed | All feeds

BioPortfolio Biotechnology Pharmaceutical Healthcare Medical Life Science Drug Discovery Disease

RAB5A


Suggest Content
Advertise Here
Gene DB Home
Symbol:RAB5A
Name(s):RAB5A, member RAS oncogene family
Type:protein-coding
Organism:Homo sapiens
Synonyms:RAB5
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18005733 B coxsackievirus entry depends on occludin and require the activity of Rab34, Ras, and Rab5, GTPases known to regulate macropinocytosis.
17524504 Results suggest that Rab5 and RalA regulate P-gp trafficking between the plasma membrane and an intracellular compartment.
17581628 The crystal structures of human APPL1 N-terminal BAR-PH domain motif, is reported.
17301141 Rab5 participates in the hepatitis C virus RNA replication machinery.
17301152 Rab 5 is required for the cellular entry of dengue and West Nile viruses.
17473071 TSH controls Rab5a activity by promoting its GTP-bound state
14644159 increase in the concentration of copper in the medium (189 microM) rapidly induces a redistribution of the MNK protein from early sorting endosomes, positive for Rab5-myc protein, to late endosomes, containing the Rab7-myc protein
15328530 Rab5 regulates and coordinates different endocytic mechanisms through its effector Rabankyrin-5
15023538 Guanine nucleotide binding state of rab5 has no bearing on the rate of EGFR endocytosis. However, expression of dominant negative rab5 affects downstream endocytic trafficking by slowing the ligand-induced disappearance of total cellular EGFR.
11792815 Expression of a GTPase-hydrolysis-defective rab5a affects lysosome biogenesis by alteration of traffic between lysosomes and endosomes.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDAngiotensin receptor 1RAB5A, member RAS oncogene family--Pubmed
HPRDangiotensin II receptor, type 1Ras related protein Rab 5A--Pubmed
HPRDchoroideremia-like Rab escort protein 2RAB5A, member RAS oncogene family--Pubmed
HPRDchoroideremia-like Rab escort protein 2RAB5A, member RAS oncogene family--Pubmed
HPRDGDP dissociation inhibitor 2RAB5A, member RAS oncogene family--Pubmed
HPRDGDP dissociation inhibitor 2 isoform 1Ras related protein Rab 5A--Pubmed
HPRDRas related protein Rab 5Atuberous sclerosis 2 isoform 1--Pubmed
HPRDRas related protein Rab 5Arabaptin, RAB GTPase binding effector protein 1 isoform 1--Pubmed
HPRDRas related protein Rab 5ARas and Rab interactor 2--Pubmed
HPRDRas related protein Rab 5ARAB37, member RAS oncogene family isoform 3--Pubmed

Recent Publications on RAB5A:

Pubmed Logo
Subcellular localization of the neuronal glycine transporter GLYT2 in brainstem.
The neuronal glycine transporter GLYT2 belongs to the...
15th October, 2009
Departamento de Biologia Molecular and Centro de Biologia Molecular Traffic. 2009 Jul;10(7):829-43. Epub 2009 Mar 17.
DOI Direct Link
Insight into the molecular switch mechanism of human Rab5a from molecular dynamics simulations.
Rab5a is currently a most interesting target because it is responsible for...
13th October, 2009
Key Laboratory of Systems Biology, Shanghai Institutes for Biological Biochem Biophys Res Commun. 2009 Oct 9.
DOI Direct Link
Rab5 isoforms differentially regulate the trafficking and degradation of epidermal growth factor receptors.
Ligand-mediated endocytosis is an intricate regulatory mechanism for...
3rd September, 2009
Department of Cell Biology and Physiology, Washington University School of J Biol Chem. 2009 Oct 30;284(44):30328-38. Epub 2009 Sep 1.
DOI Direct Link
CFTR and defective endocytosis: new insights in the renal phenotype of cystic fibrosis.
Inactivation of the chloride channel cystic fibrosis transmembrane...
21st August, 2009
Division of Nephrology, Universite catholique de Louvain Medical School, Pflugers Arch. 2009 Apr;457(6):1227-36. Epub 2008 Oct 7.
DOI Direct Link
Sequential signaling in plasma-membrane domains during macropinosome formation in macrophages.
Macropinosomes are large endocytic vesicles that form in ruffling regions...
20th August, 2009
Department of Microbiology and Immunology, University of Michigan Medical J Cell Sci. 2009 Sep 15;122(Pt 18):3250-61. Epub 2009 Aug 18.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
6750012 Method of identifying a psychotropic agent using differential gene expression
7348469 Plant farnesyltransferases
7427489 Screening assay to identify modulators of the sleep/wake cycle
7447594 Molecular cardiotoxicology modeling
7467046 Geranylgeranyl transferase type I (GGTase-I) structure and uses thereof

View more patents.

RAB5A results (if any) from reagent suppliers

Google CSE Logo
Antibodies to Endosomes
mouse ... Rab5a(271457), human, rat, mouse, IF (i), WB, pricing ... rat ... Rab5a(64633), cat, mouse, rat, human, bovine, ARR, ELISA (i), ICC, WB, pricing
...
https://www.sigmaaldrich.com/etc/controller/controller-page....

Thumbshot
Rab 5A (S-19) Antibody sc-309
Agonist-dependent internalization and trafficking of the human prostacyclin receptor: A direct role for Rab5a GTPase [Epub ahead of print]. ...
http://www.scbt.com/datasheet-309-rab-5a-s-19-antibody.html...

Thumbshot
Phosphotyrosine antibody (HRP) (ab9329) | Abcam
... of p67phox and p40phox That Requires Recruitment and Activation of p38 MAPK, Rab5a, and Phosphatidylinositol 3-Kinase in Human Neutrophils. ...
http://www.abcam.com/Phosphotyrosine-antibody-HRP-ab9329.htm...

Thumbshot
Rab 5 (D-11) Antibody sc-46692
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIMâ„¢ Number. Human, RAB5A, 5868, 3p24.3, NM_004162 ...
http://www.scbt.com/datasheet-46692-rab-5-d-11-antibody.html...

Thumbshot
Rab5 antibody - Early Endosome Marker (ab13253) | Abcam
Synthetic peptide: PKNEPQNPGANSARGR conjugated to KLH, corresponding to amino acids 182-197 of Human Rab5 (Rab5A) BLAST 'PKNEPQNPGANSARGR' with BLAST the ...
http://www.abcam.com/r-antibody-early-endosome-marker-ab1325...

Thumbshot
Home | ARP American Research Products, Inc.
Anti-ACOT11, human · Rab5a, human · Anti-HSP105 alpha, human · Anti-BHMT, human · Anti-p62 Protein (C) · Anti-Clusterin, human · Anti-Nanog, human ...
http://www.arp1.com/...

Thumbshot
APPL1
The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. ...
http://www.immuquest.com/AntibodyDetails.asp?AntibodyID=1314...

Thumbshot

Search Bioportfolio and other Life Science Sites for RAB5A, or search for RAB5A on BioPortfolio's antibody search engine.
This page has been viewed 200 times
Recent Search Terms used to find this page:
Rab5a role | abcam rab5 antibody and mouse icc | Rab5a Cat. | .


Resources from the NCBI used on this page, NCBI's standard disclaimer applies.

 

Nothing in this website should be used in place of personal medical advice from your own qualified medical practitioner.

All rights reserved. All other trademarks recognized.
Copyright 1997-2009 - BioPortfolio Limited.