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RAD51

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Symbol:	RAD51
Name(s):	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)
Type:	protein-coding
Organism:	Homo sapiens
Synonyms:	BRCC5, HRAD51, HsRad51, HsT16930, RAD51A, RECA
Links:	Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications
Publication Link	Summary of findings
18256600	fission yeast (Rhp51) and human (hRad51) RecA homologues promote duplex-duplex DNA-strand exchange in vitro
17549502	The output 3D molecular structure from the combination between BRCA2-RAD51 is derived
18033323	XRCC3 Thr241Met, RAD51 G135C and GSTM1 genotypes did not increase susceptibility to AML when assessed singly, but when XRCC3 and RAD51 genotypes were examined together an increase in susceptibility to AML was seen in children with variant alleles
11248061	Observational study of gene-gene interaction. (HuGE Navigator)
11535547	Observational study of gene-disease association. (HuGE Navigator)
12023982	Observational study of gene-disease association. (HuGE Navigator)
12036913	Observational study of gene-disease association. (HuGE Navigator)
12673366	Observational study of gene-disease association. (HuGE Navigator)
12750242	Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
12883740	Observational study of gene-disease association. (HuGE Navigator)
→View more information from publications.

Interacting gene products
Interaction Type	Gene 1	Gene 2	Interaction description	Complex	Publication Link
HPRD	BLM	RAD51 homolog protein isoform 1	-	-	Pubmed
HPRD	Bloom syndrome protein	RAD51	-	-	Pubmed
BIND	Bloom syndrome protein	RAD51 homolog protein isoform 1	BLM interacts with RAD51.	-	Pubmed
HPRD	breast cancer 1, early onset isoform 1	RAD51 homolog protein isoform 1	-	-	Pubmed
HPRD	breast cancer 1, early onset isoform 1	RAD51 homolog protein isoform 1	-	-	Pubmed
BIND	breast cancer 1, early onset isoform 1	RAD51 homolog protein isoform 1	BRCA1 and Rad51 associate in mitotic and meiotic cells	-	Pubmed
BIND	breast cancer 1, early onset isoform 1	RAD51 homolog protein isoform 2	BRCA1 and Rad51 associate in mitotic and meiotic cells	-	Pubmed
HPRD	BRCA2	RAD51 homolog protein isoform 1	-	-	Pubmed
HPRD	breast cancer 2, early onset	RAD51	-	-	Pubmed
BIND	breast cancer 2, early onset	-	BRCA2 interacts with an unspecified isoform of RAD51.	-	Pubmed

Recent Publications on RAD51:
Two modules in the BRC repeats of BRCA2 mediate structural and functional interactions with the RAD51 recombinase. The breast and ovarian cancer suppressor protein BRCA2 controls the RAD51...	31st October, 2009	The Medical Research Council Cancer Cell Unit, Hutchison/MRC Research	Nucleic Acids Res. 2009 Oct 29. DOI Direct Link
RAD51 paralogs promote homology-directed repair at diversifying immunoglobulin V regions. ABSTRACT: BACKGROUND: Gene conversion depends upon the same factors that...	30th October, 2009		BMC Mol Biol. 2009 Oct 28;10(1):98. DOI Direct Link
Differential Cellular Responses to Prolonged LDR-IR in MLH1-Proficient and MLH1-Deficient Colorectal Cancer HCT116 Cells. PURPOSE: MLH1 is a key DNA mismatch repair (MMR) protein involved in...	29th October, 2009	Authors' Affiliation: Department of Radiation Oncology and the Case	Clin Cancer Res. 2009 Oct 27. DOI Direct Link
Involvement of a chromatin remodeling complex in damage tolerance during DNA replication. ATP-dependent chromatin remodeling complexes have been shown to...	27th October, 2009	[1] Department of Carcinogenesis, Science Park Research Division, M.D.	Nat Struct Mol Biol. 2009 Oct 25. DOI Direct Link
Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation. Smad4 is a central mediator of TGF-beta signaling, and its expression is...	21st October, 2009		J Clin Invest. 2009 Nov 2;119(11):3408-3419. doi: 10.1172/JCI38854. Epub DOI Direct Link
→View more research publications.

Press Releases on RAD51:
Pharmacyclics announces Global Strategic Alliance with Les Laboratoires Servier	17th April, 2009	Pharmacyclics	Pharmacyclics to maintain all US Rights Conference Call to discuss the company's third quarter financial results is scheduled for April 23, 2009 at 11:00 a.m. EDT

BioNews Results for RAD51 :
GSK to Exploit SuperGens Epigenetics Expertise in Cancer Collaboration	Genetic Engineering News: Oct 26 2009 2:46PM Matching: rad51

Clinical Trials:
MP470 and Chemotherapy in Treating Patients With Cancer

Patents:
US Patent No.	Title
7332277	Methods for detection of genetic disorders
7407957	Phthalazinone derivatives
7435561	Methods for multiplexing recombinase polymerase amplification
7435589	Methods of diagnosis of ovarian cancer, compositions and methods of screening for modulators of ovarian cancer
7442506	Methods for detection of genetic disorders
→View more patents.

RAD51 results (if any) from reagent suppliers

The Abcam catalog Rad51 antibodies. ... Rad51 antibody [51RAD01]. IHC-P, IP, WB, ICC/IF, IHC-Fr ... Rad51 antibody [51RAD01] (Biotin). IHC-P, WB, IP. Mouse monoclonal ... http://www.abcam.com/index.html?t=200&pt=1&c=879...
Rad51 antibody, Rad51 [13E4] Antibody, Mouse Monoclonal Antibody Buy quality mouse Rad51 antibody (interacts with human - not yet tested in other species ), anti-Rad51, Rad51 [13E4] antibody, mouse monoclonal antibody, ... http://www.genwaybio.com/product_info.php?products_id=193366...
Rad51 antibody [Rad51 3C10] (ab20240) \| Abcam Mouse monoclonal [Rad51 3C10] to Rad51. Rad51 is a recombinase that is essential for homologous recombination and double-strand break repair. http://www.abcam.com/Rad51-antibody-Rad51-3C10-ab20240.html...
Anti-RAD51 Polyclonal Antibody Polyclonal Antibody against RAD51 for use in ELISA, Immunoprecipitation, Western Blot. http://www.bioreagents.com/products/productDetails/productDe...
Rad51 antibody (ab63801) \| Abcam Rabbit polyclonal to Rad51. Rad51 is a recombinase that is essential for homologous recombination and double-strand break repair. http://www.abcam.com/Rad51-antibody-ab63801.html...
Rad51 (3C10) Antibody sc-53428 See how others have used Rad51 (3C10): sc-53428 antibody and or Rad51 (3C10) ... Western blot analysis of Rad51 expression in non-transfected: sc-117752 (A) ... http://www.scbt.com/datasheet-53428-rad51-3c10-antibody.html...
R1528 Anti-RAD51 antibody produced in rabbit affinity isolated ... R1528 Anti-RAD51 antibody produced in rabbit affinity isolated antibody, ammonium sulfate suspension. http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=R152...

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