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RAF1
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18241070 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18182859 |
These results suggest that 0.05 Gy of ionizing radiation stimulates cell proliferation through the transient activation of Raf and Akt in CCD-18 Lu cells. |
| 18006502 |
Raf-1 in beta-cells led to a striking loss of Bad phosphorylation at serine 112 and an increase in the protein levels of both Bad and Bax |
| 17998336 |
activated Ras, Golgi apparatus-localized Lck is needed for the full activation of Raf-1 |
| 17572489 |
results show overexpression of RAF-1 in mantle cell leukemia compared with tonsilar B-lymphocytes |
| 17018604 |
cAMP suppresses CRAF in melanocytes. This suppresses the oncogenic potential of CRAF. When RAS is mutated in melanoma, the cells switch their signaling from BRAF to CRAF, dysregulating cAMP signaling & allowing CRAF to signal to MEK. |
| 17635919 |
In contrast to C-RAF that requires farnesylated H-Ras, cytosolic B-RAF associates effectively and with significantly higher affinity with both farnesylated and nonfarnesylated H-Ras. |
| 17724343 |
reveal a paradigm of spatial regulation of Raf kinase by RKTG via sequestrating Raf-1 to the Golgi apparatus and thereby inhibiting the ERK signaling pathway |
| 17603482 |
Study identified 5 mutations in RAF1 in 10 individuals with Noonan syndrome; those with mutations causing changes in the CR2 domain of RAF1 had hypertrophic cardiomyopathy, while those with mutations leading to changes in the CR3 domain did not. |
| 17603483 |
Study reports that 18 of 231 individuals with Noonan syndrome and 2 of 6 individuals with LEOPARD syndrome without PTPN11 mutations have missense mutations in RAF1, which encodes a serine-threonine kinase that activates MEK1 and MEK2. | →View more information from publications. |
Recent Publications on RAF1: |  |
Protein chip analysis of pluripotency-associated proteins in NIH3T3 fibroblast.
Specific transcription factors regulate the totipotent and pluripotent... | 30th October, 2009
| Department of Biomedical Sciences, CHA Stem Cell Institute, CHA
| Proteomics. 2009 Aug;9(16):3968-78.
DOI Direct Link |
Selective antagonism of anticancer drugs for side-effect removal.
By interfering with signal transduction events that control cell... | 22nd October, 2009
| Department of Bioengineering, Rice University, Houston, TX 77005, USA.
| Trends Pharmacol Sci. 2009 Aug;30(8):403-10.
DOI Direct Link |
Amplification and expression of EGFR and ERBB2 in Wilms tumor.
Wilms tumor is one of the most common solid tumors in children. We... | 9th October, 2009
| Department of Pathology, Shiraz Medical School and Shiraz Institute of
| Cancer Genet Cytogenet. 2009 Oct 15;194(2):88-95.
DOI Direct Link |
Effect of curcumin on nuclear factor kappaB signaling pathways in human chronic myelogenous K562 leukemia cells.
Curcumin, a natural product isolated from the plant Curcuma longa, has a... | 24th September, 2009
| Laboratoire de Biologie Moleculaire et Cellulaire du Cancer, Hopital
| Ann N Y Acad Sci. 2009 Aug;1171:436-47.
DOI Direct Link |
Tumor suppressor Ras-association domain family 1 isoform A is a novel regulator of cardiac hypertrophy.
BACKGROUND: Ras signaling regulates a number of important processes in the... | 22nd September, 2009
| Cardiovascular Medicine Research Group, School of Clinical and Laboratory
| Circulation. 2009 Aug 18;120(7):607-16. Epub 2009 Aug 3.
DOI Direct Link |
→View more research publications. |
RAF1 results (if any) from reagent suppliers | 
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