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RASA1
| Symbol: | RASA1 | | Name(s): | RAS p21 protein activator (GTPase activating protein) 1 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | CM-AVM, CMAVM, DKFZp434N071, GAP, PKWS, RASA, RASGAP, p120GAP, p120RASGAP | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18024870 |
Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 11751853 |
We show a novel alternative pathway of apoptosis in human primary cells that is mediated by transcriptionally dependent decreases in p53 and c-Myc and decreases in p21. |
| 15010862 |
p21Ras, hSOS1, and p120GAP are not involved in polycystic ovary disease |
| 11847220 |
N-terminal fragment generated by caspase cleavage protects cells in a Ras/PI3K/Akt-dependent manner that does not rely on NFkappa B activation |
| 15688026 |
p52Shc couples tyrosine kinase receptors to Ras by recruiting Grb2/Sos complexes. |
| 12730209 |
mutual regulation of Ras and NF1-GAP is essential for normal neuronal differentiation |
| 16046410 |
an uncleavable N-terminal RasGAP fragment in insulin-secreting cells has a role in increasing resistance toward apoptotic stimuli without affecting glucose-induced insulin secretion |
| 15187129 |
ligation of CD40 on EC increased association of Ras with its effector molecules Raf, Rho, and PI3K. But, it was determined that only PI3K was functional for Ras-induced VEGF transcription. |
| 15041706 |
The induction of p21 gene expression is mediated by PPARgamma ligands in lung carcinoma. |
| 15542850 |
executioner caspases control the extent of their own activation by a feedback regulatory mechanism initiated by the partial cleavage of RasGAP that is crucial for cell survival under adverse conditions | →View more information from publications. |
Recent Publications on RASA1: |  |
Genetic alterations and oncogenic pathways associated with breast cancer subtypes.
Breast cancers can be divided into subtypes with important implications... | 15th May, 2009
| Department of Bioinformatics, Genentech, Inc., South San Francisco, CA,
| Mol Cancer Res. 2009 Apr;7(4):511-22.
DOI Direct Link |
p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities.
DLC1 (deleted in liver cancer 1), which encodes a Rho GTPase-activating... | 2nd April, 2009
| Laboratory of Experimental Carcinogenesis, Center for Cancer Research,
| Oncogene. 2009 Mar 19;28(11):1401-9. Epub 2009 Jan 19.
DOI Direct Link |
A novel mutation in RASA1 causes capillary malformation and limb enlargement.
Capillary malformations are common vascular malformations. Several... | 17th December, 2008
| Department of Dermatology and Laboratory of Molecular Dermatology, Rambam
| Arch Dermatol Res. 2008 Aug;300(7):385-8. Epub 2008 Mar 8.
DOI Direct Link |
Parkes Weber syndrome, vein of Galen aneurysmal malformation, and other fast-flow vascular anomalies are caused by RASA1 mutations.
Capillary malformation-arteriovenous malformation (CM-AVM) is a newly... | 30th August, 2008
| Laboratory of Human Molecular Genetics, de Duve Institute, Universite
| Hum Mutat. 2008 Jul;29(7):959-65.
DOI Direct Link |
RASA1 mutations may cause hereditary capillary malformations without arteriovenous malformations.
BACKGROUND: Capillary malformation (CM), a common vascular abnormality, is... | 30th August, 2008
| Laboratory of Molecular Dermatology, Department of Dermatology, Rambam
| Br J Dermatol. 2008 May;158(5):1035-40. Epub 2008 Mar 20.
DOI Direct Link |
→View more research publications. |
RASA1 results (if any) from reagent suppliers | 
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RASA1 monoclonal antibody (M01)
RASA1 monoclonal antibody (M01), clone 2C12 Western Blot analysis of RASA1 ... Immunoperoxidase of monoclonal antibody to RASA1 ( Cat # AT3574a ) on ...
http://www.abgent.com/products/catalog_no/AT3574a_RASA1_mono...
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Antibodies to Rho and Related Proteins
purified immunoglobulin, rat ... Rasa1(25676) human ... RASA1(5921) mouse ... Rasa1(218397), mouse, bovine, rat, human, hamster, ICC, IP, WB ...
https://www.sigmaaldrich.com/etc/controller/controller-page....
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Ras GAP (D4B4) Antibody sc-64
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, RASA1, 5921, 5q14.3, NM_002890, ...
http://www.scbt.com/datasheet-64-ras-gap-d4b4-antibody.html...
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Lck antibody, Lck phospho Y192 Antibody, Rabbit Polyclonal Antibody
Also binds to effector molecules, such as PI4K, VAV1, RASA1, FYB and to other protein kinases including CDC2, RAF1, ZAP70 and SYK. ...
http://www.genwaybio.com/product_info.php?products_id=197396...
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Abgent - Cell and Structure Antibodies - Cell_structure
AT3574aNEW, RASA1 monoclonal antibody (M01), ELISA,IHC-P,WB-Ce,WB-Re, H. AT3575a NEW, RASA3 monoclonal antibody (M01), ELISA,S-ELISA,WB-Re, H ...
http://www.abgent.com/products/category/cell_function/cell_s...
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Ras GAP Antibody / Ras GAP Antibodies
PRODUCT NAME, CATALOG #, ISOTYPE, EPITOPE, APPLICATIONS, SPECIES. Ras GAP (B4F8) Antibody, sc-63, mouse IgG2a, FL (h), WB, IP, IF, FCM, ELISA, m, r, h ...
http://www.scbt.com/table-ras_gap.html...
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Cell Death Survey
RASA1. TNF. TRAF2. RIPK1. TNFRSF1A*. CASP3*. TRAF1. TRAF3. CASP8*. CASP10*. TRAF6. CYLD*. TRAF7. TTRAP. TRAF5. IKBKG. TRAIP. SPATA2*. HSP90AA1. PARP2. GRB2
...
http://www.abgent.com/downloads/posters/necroptosis.pdf...
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