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RB1


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Gene DB Home
Symbol:RB1
Name(s):retinoblastoma 1 (including osteosarcoma)
Type:protein-coding
Organism:Homo sapiens
Synonyms:OSRC, RB
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17916908 compromise of either p53 or Rb pathways during melanocyte transformation leads to up-regulation of survivin expression in melanoma
18306932 Analysis of the pattern of expression of these biomolecules showed increased p16-positive phenotypes and decreased cyclin D1- and pRB-positive phenotype among the invasive tumors compared to low-grade CIN lesions
18281541 Observational study of gene-disease association. (HuGE Navigator)
11568901 Observational study of genetic testing. (HuGE Navigator)
11832063 Observational study of gene-disease association. (HuGE Navigator)
14631100 Observational study of genotype prevalence and gene-disease association. (HuGE Navigator)
14722923 Observational study of genetic testing. (HuGE Navigator)
15162822 Observational study of genotype prevalence. (HuGE Navigator)
15523694 Observational study of gene-disease association. (HuGE Navigator)
15763650 Observational study of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDABLretinoblastoma 1--Pubmed
HPRDv-abl Abelson murine leukemia viral oncogene homolog 1 isoform aRetinoblastoma 1--Pubmed
HPRDv-abl Abelson murine leukemia viral oncogene homolog 1 isoform aretinoblastoma 1--Pubmed
BINDv-abl Abelson murine leukemia viral oncogene homolog 1 isoform aretinoblastoma 1Rb interacts with c-Abl-Pubmed
HPRDaryl hydrocarbon receptorretinoblastoma 1--Pubmed
HPRDaryl hydrocarbon receptorretinoblastoma 1--Pubmed
BINDHuman apoptosis inhibitor survivin gene, and translated productsretinoblastoma 1RB1 (pRB) interacts with the BIRC5 (survivin) promoter.-Pubmed
HPRDandrogen receptor isoform 1retinoblastoma 1--Pubmed
HPRDandrogen receptor isoform 1retinoblastoma 1--Pubmed
BINDandrogen receptor isoform 1retinoblastoma 1Rb interacts with AR.-Pubmed

Recent Publications on RB1:

Pubmed Logo
Retinoblastoma 1 Protein Modulates XY Germ Cell Entry into G1/G0 Arrest During Fetal Development in Mice.
During mouse germ cell development, the first sign of sex differentiation...
30th October, 2009
Biol Reprod. 2009 Oct 28.
DOI Direct Link
Emerging roles of E2Fs in cancer: an exit from cell cycle control.
Mutations of the retinoblastoma tumour suppressor gene (RB1) or components...
24th October, 2009
Human Cancer Genetics Program, Department of Molecular Virology, Nat Rev Cancer. 2009 Nov;9(11):785-97.
DOI Direct Link
[Application of fluorescence in-situ hybridization technique in multiple myeloma.]
OBJECTIVE: To investigate the common chromosome abnormalities of the...
16th October, 2009
Department of Hematology, The First Affiliated Hospital of Sun Yat-sen Zhejiang Da Xue Xue Bao Yi Xue Ban. 2009 Sep;38(5):459-64.
Partial purification and characterization of three ginsenoside-metabolizing beta-glucosidases from Pythium irregulare.
The ginseng pathogen Pythium irregulare is able to selectively metabolize...
13th October, 2009
Department of Biology, University of Western Ontario, London, Ontario, Phytochemistry. 2009 Oct 7.
DOI Direct Link
Ginsenoside Rh2 ameliorates scopolamine-induced learning deficit in mice.
To understand memory-enhancing effect of red ginseng biotransformed by...
6th October, 2009
Department of Life and Nanopharmaceutical Sciences, Kyung HeeUniversity, Biol Pharm Bull. 2009 Oct;32(10):1710-5.

View more research publications.

BioNews Results for RB1

: RSS Logo
BioPortfolio Logo
Emerging roles of E2Fs in cancer: an exit from cell cycle control
Nature:  Oct 23 2009 4:45AM Matching: rb1
Allelic imbalance at 13q31 is associated with reduced GPC6 in Chinese with sporadic retinoblastoma
British Journal of Ophthalmology:  Oct 14 2009 11:30PM Matching: rb1
AnaSpec introduces Z-Fish antibodies for cell cycle control research
PharmaBiz:  Aug 17 2009 8:04AM Matching: rb1

Clinical Trials:

Clinical Trials Logo
Genetic Mutations and Environmental Exposure in Young Patients With Retinoblastoma and in Their Parents and Young Healthy Unrelated Volunteers

Patents:

Patents logo
US Patent No.Title
7560253 HLS-5 tumor suppressor factor
7577076 Tilt sensor using diffraction grating
7580212 Magnetic disk having efficiently stored WRRO compensation value redundancy information and method for using the redundancy information
7581072 Method and device for data buffering
7582065 Air pulse generator with multiple operating modes

View more patents.

RB1 results (if any) from reagent suppliers

Google CSE Logo
Rb (Rb1) Antibody sc-73598
Rb (Rb1): sc-73598. Western blot analysis of Rb expression in non-transfected: sc-117752 (A) and human Rb transfected: sc-114014 (B) 293T whole cell lysates
...
http://www.scbt.com/datasheet-73598-rb-rb1-antibody.html...

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RB1 Antibody
Specific antibody for the gene product of RB1, the protein Retinoblastoma 1. Validated for specificity by gene-silencing with siRNA followed by Western blot
...
http://www.piercenet.com/Products/Browse.cfm?fldID=7CAA58DB-...

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Rb antibody [Rb1 1F8] - Nuclear Marker (ab24) | Abcam
Mouse monoclonal [Rb1 1F8] to Rb - Nuclear Marker. Rb is a tumor suppressor gene which functions as a negative regulator of the cell cycle by interacting ...
http://www.abcam.com/Rb-antibody-Rb1-1F8-Nuclear-Marker-ab24...

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RB1 antibody, retinoblastoma 1 (including osteosarcoma) (RB1 ...
Buy quality mouse RB1 antibody (interacts with human), anti-RB1, retinoblastoma 1 (including osteosarcoma) (RB1) antibody, mouse monoclonal antibody, ...
http://www.genwaybio.com/product_info.php?products_id=60054...

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RB1 Antibody (S608)
Western blot analysis of anti-RB Antibody (S608) (Cat.#AP6265e) in Ramos cell line lysates (35ug/lane). RB1(arrow) was detected using the purified Pab. ...
http://www.abgent.com/products/catalog_no/AP6265e_RB1_Antibo...

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RB1 antibody, RB1 phospho S780 Antibody, Rabbit Polyclonal Antibody
Buy quality rabbit RB1 antibody (interacts with human mouse rat - not tested in other species - expected to cross-react with chicken (93% identity with ...
http://www.genwaybio.com/product_info.php?products_id=197345...

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Antibodies to Retinoblastoma (Rb) and Related Proteins
RB1(5925) rat ... Rb1(24708), rat, mouse, human, WB CL, pricing ... rat ... Rb1( 24708), human, hamster, mouse, bovine, rat, ARR, ELISA (i), IHC, WB, pricing ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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