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JARID1A


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Symbol:JARID1A
Name(s):jumonji, AT rich interactive domain 1A
Type:protein-coding
Organism:Homo sapiens
Synonyms:KDM5A, RBBP2, RBP2
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17573780 RBP2 associates with MRG15 complex to maintain reduced H3K4 methylation at transcribed regions, which may ensure the transcriptional elongation state
16645588 that RBP2-H1 exerts a broad tumor-suppressive function partially mediated by pRb modulation
17320161 Study shows that RBP2 is displaced from Hox genes during embryonic stem cell differentiation correlating with an increase of their di- and trimethylated histone 3 lysine 4 levels and expression.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDHomo sapiens chromosome 1retinoblastoma binding protein 2RBP2 interacts with OC promoter.-Pubmed
BINDestrogen receptor 1retinoblastoma binding protein 2Rbp2 interacts with ER.-Pubmed
BINDnuclear receptor subfamily 3, group C, member 1 isoform alpharetinoblastoma binding protein 2Rbp2 interacts with GR. This interaction was modeled on a demonstrated interaction between human Rbp2 and rat GR.-Pubmed
HPRDLIM domain only 2retinoblastoma binding protein 2--Pubmed
HPRDLIM domain only 2retinoblastoma binding protein 2--Pubmed
BINDretinoic acid receptor, alpha isoform aretinoblastoma binding protein 2Rbp2 interacts with RAR.-Pubmed
HPRDretinoblastoma 1retinoblastoma binding protein 2--Pubmed
BINDretinoblastoma 1retinoblastoma binding protein 2Rbp2 interacts with Rb. This interaction was modeled on a demonstrated interaction between human Rbp2 and Rb from an unspecified species.-Pubmed
BINDretinoblastoma 1retinoblastoma binding protein 2pRB interacts with RBP2.-Pubmed
HPRDRetinoblastoma binding protein 2vitamin D receptor--Pubmed

Recent Publications on JARID1A:

Pubmed Logo
Role of hypoxia-inducible factors in epigenetic regulation via histone demethylases.
Eukaryotic chromatin is subject to multiple posttranslational histone...
3rd November, 2009
Cancer Research UK, Molecular Oncology Laboratories, Weatherall Institute Ann N Y Acad Sci. 2009 Oct;1177:185-97.
DOI Direct Link
Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger.
Histone H3 lysine 4 methylation (H3K4me) has been proposed as a critical...
6th August, 2009
Laboratory of Chromatin Biology & Epigenetics, The Rockefeller University, Nature. 2009 Jun 11;459(7248):847-51.
DOI Direct Link
Mapping and expression analyses during porcine foetal muscle development of 12 genes involved in histone modifications.
Histone modifications (methylation and demethylation) regulate gene...
14th July, 2009
Lab of Molecular Biology and Animal Breeding, Key Lab of Agricultural Anim Genet. 2009 Apr;40(2):242-6. Epub 2008 Dec 30.
DOI Direct Link
Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells.
Multipotential naive CD4(+) T cells differentiate into distinct lineages...
12th February, 2009
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Immunity. 2009 Jan 16;30(1):155-67.
DOI Direct Link
Genome-wide analysis of the H3K4 histone demethylase RBP2 reveals a transcriptional program controlling differentiation.
Retinoblastoma protein (pRB) mediates cell-cycle withdrawal and...
17th September, 2008
Research Unit on Biomedical Informatics, Experimental and Health Science Mol Cell. 2008 Aug 22;31(4):520-30.
DOI Direct Link

View more research publications.

JARID1A results (if any) from reagent suppliers

Google CSE Logo
JARID1A/RBP2 Antibody Bethyl Laboratories
Rabbit anti-JARID1A/RBP2 Antibody, Affinity Purified.
http://www.bethyl.com/go/?product/A300-897A/TreeKey=20abcfbd...

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KDM5A / Jarid1A / RBBP2 antibody (ab70892) | Abcam
Rabbit polyclonal to KDM5A / Jarid1A / RBBP2. KDM5A / JARID1A / RBBP2 is a ubiquitously expressed nuclear protein. KDM5A specifically demethylates di and
...
http://www.abcam.com/KDM5A-Jarid1A-RBBP2-antibody-ab70892.ht...

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JARID1A (D28B10) XP™ Rabbit mAb #3876
JARID1A (D28B10) XP™ Rabbit mAb detects endogenous levels of total JARID1A protein (both isoforms). The antibody does not cross-react with other JARID ...
http://www.cellsignal.com/products/3876.html...

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KDM5A / Jarid1A / RBBP2 antibodies: Chromatin and Nuclear ...
KDM5A / Jarid1A / RBBP2 antibodies. ... KDM5A / Jarid1A / RBBP2 antibody. Fast Track. Rabbit polyclonal. Predicted: Hu. ab45301 · KDM5A / Jarid1A / RBBP2 ...
http://www.abcam.com/index.html?t=125887&pt=1&c=3580&ei=&mu=...

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JARID1A (D28B10) XP™ Rabbit mAb
containing protein) family contains four members: JARID1A ... mAb detects endogenous levels of total JARID1A protein. (both isoforms). ...
http://www.cellsignal.com/pdf/3876.pdf...

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KDM5A / Jarid1A / RBBP2 antibodies: Cancer > Oncoproteins ...
KDM5A / Jarid1A / RBBP2 antibodies. ... KDM5A / Jarid1A / RBBP2 antibody - ChIP Grade. IHC-P, IP, ChIP. Specific publication references. Rabbit polyclonal ...
http://www.abcam.com/index.html?t=125887&pt=1&c=4335&ei=&mu=...

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JARID1B Antibody #3273
JARID1A is a critical RB-interacting protein and is required for ... A JARID1A- NUP98 gene fusion is associated with myeloid leukemia (9). ...
http://www.cellsignal.com/products/3273.html...

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