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CCND1


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Symbol:CCND1
Name(s):cyclin D1
Type:protein-coding
Organism:Homo sapiens
Synonyms:BCL1, D11S287E, PRAD1, U21B31
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17941827 that Rac1 is an essential player for mediating the induction of cyclin D1 and p21(Cip1) by HRG in breast cancer cells
18063576 PKR and PKR-like endoplasmic reticulum kinase induce the proteasome-dependent degradation of cyclin D1 via a mechanism requiring eukaryotic initiation factor 2alpha phosphorylation
17912028 This study aimed to explore, whether polymorphisms in BCL2, Cyclin D1, FAS, EGF and EGFR genes affect survival in a cohort of patients with squamous cell esophageal cancer treated with CT+RT with a view to identify the potential therapeutic targets.
18027856 polymorphic variant of Aurora A does not appear to be associated with variation in colorectal cancer risk in HNPCC, whereas there is a more complex relationship between the Cyclin D1 polymorphism and disease risk in HNPCC
18306932 Analysis of the pattern of expression of these biomolecules showed increased p16-positive phenotypes and decreased cyclin D1- and pRB-positive phenotype among the invasive tumors compared to low-grade CIN lesions
18205772 Observational study of gene-disease association. (HuGE Navigator)
18226366 Observational study of gene-disease association. (HuGE Navigator)
18237245 Observational study of gene-disease association. (HuGE Navigator)
18251939 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18281541 Observational study of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDandrogen receptor isoform 1cyclin D1--Pubmed
HPRDCyclin D1cyclin-dependent kinase 4--Pubmed
HPRDCyclin D1estrogen receptor 1--Pubmed
HPRDCyclin D1retinoblastoma 1--Pubmed
HPRDCyclin D1E1A binding protein p300--Pubmed
HPRDCyclin D1MYB-related protein B--Pubmed
HPRDCyclin D1thyroid hormone receptor, alpha isoform 2--Pubmed
HPRDCyclin D1nuclear receptor coactivator 1 isoform 1--Pubmed
HPRDCyclin D1p300/CBP-associated factor--Pubmed
HPRDCyclin D1interferon, alpha-inducible protein 27--Pubmed

Recent Publications on CCND1:

Pubmed Logo
Focal amplification and oncogene dependency of GAB2 in breast cancer.
DNA amplifications in breast cancer are frequent on chromosome 11q, in...
3rd November, 2009
Department of Pathology, Stanford University, Stanford, CA, USA. Oncogene. 2009 Nov 2.
DOI Direct Link
Cytogenetic findings in an epithelioid sarcoma with angiomatoid features. A case report.
Epithelioid sarcoma is a rare, aggressive soft tissue tumor of unknown...
30th October, 2009
Departamento de Puericultura e Pediatria, Faculdade de Medicina de Genet Mol Res. 2009 Oct 6;8(4):1211-7.
DOI Direct Link

In Reponse: Drs. Viprey and Burchill assert superiority of their marker...
29th October, 2009
Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New Clin Cancer Res. 2009 Oct 27.
DOI Direct Link
Gene Expression Profiling for Discovery of Novel Markers of Minimal Disease.
To the Editor: As Cheung et al. (1) report, accurate assessment of minimal...
29th October, 2009
Children's Cancer Research Group, Section of Experimental Oncology, Leeds Clin Cancer Res. 2009 Oct 27.
DOI Direct Link
Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation.
Hedgehog signaling is aberrantly activated in glioma, medulloblastoma,...
29th October, 2009
M & M Medical Bioinformatics, Hongo 113-0033, Japan. Curr Mol Med. 2009 Sep;9(7):873-86.

View more research publications.

Clinical Trials:

Clinical Trials Logo
Efficacy Study Of P276-00 In Subjects Of Malignant Melanoma Positive For Cyclin D1 Expression

Patents:

Patents logo
US Patent No.Title
7308364 Diagnosis of multiple myeloma on gene expression profiling
7399828 Secreted and transmembrane polypeptides and nucleic acids encoding the same
7402661 Secreted and transmembrane polypeptides and nucleic acids encoding the same
7405268 Secreted and transmembrane polypeptides and nucleic acids encoding the same
7405269 Secreted and transmembrane polypeptides and nucleic acids encoding the same

View more patents.

CCND1 results (if any) from reagent suppliers

Google CSE Logo
CCND1 Antibody
Specific antibody for the gene product of CCND1, the protein Cyclin D1. Validated for specificity by gene-silencing with siRNA followed by Western blot
...
http://www.piercenet.com/products/Browse.cfm?fldID=5B885FEF-...

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cyclin D1 (DCS-6) Antibody sc-20044
CHROMOSOMAL LOCATION, Genetic locus: CCND1 (human) mapping to 11q13; Ccnd1 ( mouse) mapping to 7 F5.. SOURCE, cyclin D1 (DCS-6) is a mouse monoclonal ...
http://www.scbt.com/datasheet-20044-cyclin-d1-dcs-6-antibody...

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Cyclin D1 Antibody (S90)
CCND1 protein; Cyclin D1, isoform CRA_c; cDNA, FLJ93625, Homo sapiens cyclin D1 (PRAD1: parathyroid adenomatosis 1) (CCND1),mRNA; Cyclin D1; ...
http://www.abgent.com/products/catalog_no/AP2612d_Cyclin_D1_...

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cyclin D1 (HD11) Antibody sc-246
CHROMOSOMAL LOCATION, Genetic locus: CCND1 (human) mapping to 11q13; Ccnd1 ( mouse) mapping to 7 F5. . SOURCE, cyclin D1 (HD11) is a mouse monoclonal ...
http://www.scbt.com/datasheet-246-cyclin-d1-hd11-antibody.ht...

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C7464 Monoclonal Anti-Cyclin D1 antibody produced in mouse clone ...
isotype, IgG2a. Gene Information, human ... CCND1(595). rat ... Ccnd1(58919). mouse ... Ccnd1(12443). shipped in, dry ice. storage temp. −20°C ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=C746...

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CDK4/CCND1 Recombinant Human Cyclin-Dependent Kinase 4 (aa 4-303 ...
and human CCND1, amino acids Q4-I295 (as in GenBank entry NM_053056)*, both N- ... GST-CCND1: 59.99 kDa. Cell Sciences. Toll Free: 888-769-1246. E-mail: ...
http://www.cellsciences.com/PDF/CRC033.pdf...

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Antibodies to Cyclins and CDKs
ascites fluid, human ... CCND1(595) mouse ... Ccnd1(12443) rat ... Ccnd1(58919), human, monkey, rat, mouse, ARR, ICC, IHC (f), IHC (p), IP, WB, pricing ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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