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BCL2


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Gene DB Home
Symbol:BCL2
Name(s):B-cell CLL/lymphoma 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:Bcl-2
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17912028 This study aimed to explore, whether polymorphisms in BCL2, Cyclin D1, FAS, EGF and EGFR genes affect survival in a cohort of patients with squamous cell esophageal cancer treated with CT+RT with a view to identify the potential therapeutic targets.
18023359 IL-10 modulated the pro-apoptotic capacity of TNF-alpha in chondrocytes as shown by the decrease in caspase activities and bax/bcl-2 ratio
18182854 substitution of C-terminal tail or tail & adjacent loop of Bcl-2 with equivalent regions from Bak or Bax mutant resulted in association with mitochondria. change in subcellular localization of Bcl-2 chimeras triggered cells to undergo apoptotis
18046447 our data do not support the use of the (-938C>A) BCL-2 polymorphism as a prognostic marker in CLL and argue against its postulated role in modulating Bcl-2 levels.
18046449 GCs induce both pro- and anti-apoptotic BCL2 family member-dependent pathways, with the outcome depending on cellular context and additional signals feeding into the BCL2 rheostat.
16215670 These findings imply that some of the biological functions of Bcl-2 may be attributed to their ability to inhibit anticancer agents-induced apoptosis through the sustained Akt activation.
18334006 this study has found bcl-2 of no value as a prognostic marker in this group of serous ovarian tumors
18162459 In thyroid glands of patients with Graves disease the regulation of Fas/Fas ligand/Bcl-2 favors apoptosis of infiltrating lymphocytes.
17693666 Risk for head and neck squamous cell carcinoma may be assocated with single-nucleotide polymorphism in the promoter region.
17959858 BCL2 protein levels in CLL reflect a complex interplay of transcriptional and posttranscriptional controls, but do not appear to be associated with the -938C>A promoter SNP.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDADP ribosyl transferaseB-cell lymphoma protein 2 alpha isoform--Pubmed
HPRDATPase, Ca++ transporting, cardiac muscle, slow twitch 2 isoform 1B-cell lymphoma protein 2 alpha isoform--Pubmed
HPRDATPase, Ca++ transporting, cardiac muscle, slow twitch 2 isoform 1B-cell lymphoma protein 2 alpha isoform--Pubmed
HPRDBCL2 antagonist of cell deathB-cell lymphoma protein 2 alpha isoform--Pubmed
HPRDBCL2-antagonist of cell death proteinBcl 2--Pubmed
BINDBCL2-antagonist of cell death protein-Bad interacts with Bcl-2.-Pubmed
BINDBCL2-antagonist of cell death proteinB-cell lymphoma protein 2 alpha isoformBcl-2 interacts with Bad.-Pubmed
BINDBCL2-antagonist of cell death proteinB-cell lymphoma protein 2 alpha isoformBad interacts with Bcl-2.-Pubmed
HPRDBCL2-associated athanogene isoform 1LB-cell lymphoma protein 2 alpha isoform--Pubmed
HPRDBCL2-associated athanogene isoform 1LB-cell lymphoma protein 2 alpha isoform--Pubmed

Recent Publications on BCL2:

Pubmed Logo
Repeated cocaine administration increases B-cell leukemia/lymphoma 2 phosphorylation in the rat dorsal striatum.
Protein phosphorylation caused by drug administration is a critical step...
3rd November, 2009
Department of Biological Sciences, Pusan National University, 30 Neurosci Lett. 2009 Oct 29.
DOI Direct Link
EM011 activates a survivin-dependent apoptotic program in human non-small cell lung cancer cells.
ABSTRACT: BACKGROUND: Lung cancer remains a leading cause of cancer death...
3rd November, 2009
Mol Cancer. 2009 Oct 30;8(1):93.
DOI Direct Link
Poor outcome in patients with diffuse large B-cell lymphoma is associated with high percentage of bcl-2 and Ki 67-positive tumor cells.
BACKGROUND/AIM: Newly diagnosed patients with diffuse large B-cell...
3rd November, 2009
Clinical Center of Serbia, Institute of Hematology, Belgrade, Serbia. Vojnosanit Pregl. 2009 Sep;66(9):738-43.
CCL2 is induced by chemotherapy and protects prostate cancer cells from docetaxel-induced cytotoxicity.
BACKGROUND: Metastatic prostate cancer is either inherently resistant to...
30th October, 2009
Division of Hematology and Medical Oncology, Oregon Health & Science Prostate. 2009 Oct 28.
DOI Direct Link
A coumarin derivative (RKS262) inhibits cell-cycle progression, causes pro-apoptotic signaling and cytotoxicity in ovarian cancer cells.
Coumarin derivative RKS262 belongs to a new class of potential anti-tumor...
30th October, 2009
Molecular Therapeutics Laboratory, Program in Women's Oncology, Department Invest New Drugs. 2009 Oct 29.
DOI Direct Link

View more research publications.

Press Releases on BCL2:

BioPortfolio Logo
Clarient Launches New Breast Cancer Test 5th May, 2009 Clarient, Inc.

The Clarient Insight(R) Dx Breast Cancer Profile Assists Physicians In Identifying Recurrence Risk and the Need for Chemotherapy

ALISO VIEJO, Calif., May 5 /PRNewswire

BioNews Results for BCL2

: RSS Logo
BioPortfolio Logo
'Edgetic' perturbation of a C. elegans BCL2 ortholog
Nature Nanotechnology:  Oct 29 2009 6:46PM Matching: bcl2
VDAC2 is required for truncated BID-induced mitochondrial apoptosis by recruiting BAK to the mitochondria
International Journal of Impotence Research:  Oct 9 2009 5:14PM Matching: bcl2

Clinical Trials:

Clinical Trials Logo
ACVBP Followed by ASCT in Patients With BCL-2 Positive Diffuse Large B-Cell Lymphoma

Patents:

Patents logo
US Patent No.Title
7571055 Systemic lupus erythematosus
7585634 Method of predicting risk of lung cancer recurrence, and a composition, kit and microarray for the same
7585637 Estrogen related receptor, ERR.alpha., a regulator of bone formation
7585947 IL-7 drug substance, composition, preparation and uses
7585964 Methods of analyzing chromosomal translocations using fluorescence in situ hybridization (FISH)

View more patents.

BCL2 results (if any) from reagent suppliers

Google CSE Logo
Bcl-2 Antibody #2876
Bcl-2 Antibody detects endogenous levels of Bcl-2. No cross reactivity was detected with other family members at physiological levels. ...
http://www.cellsignal.com/products/2876.html...

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Bcl2 antibody (ab18210) | Abcam
Rabbit polyclonal to Bcl2. BCL2 is an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes.
http://www.abcam.com/Bcl2-antibody-ab18210.html...

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Bcl-2 Antibody / Bcl-2 Antibodies
Bcl-2 Antibody / Bcl-2 Antibodies. ... Bcl-2 specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-bcl-2.html...

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Bcl-2 Antibody (BH3 Domain Specific)
Bcl-2 Antibody (BH3 Domain Specific) Apoptosis, Bcl-2 Antibody (BH3 Domain Specific) Cell Function, Bcl-2 Antibody (BH3 Domain Specific) Cancer, Bcl-2 ...
http://www.abgent.com/catalog_no/AP1303a...

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Bcl-2 (100) Antibody sc-509
See how others have used Bcl-2 (100): sc-509 antibody and or Bcl-2 (100) antibody ... Bcl-2 (100) PE: sc-509 PE. Intracellular FCM analysis of fixed and
...
http://www.scbt.com/datasheet-509-bcl-2-100-antibody.html...

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The Abcam catalog
Bcl2 antibodies. ... Bcl2 (phospho S70) antibody. Flow Cyt, IP, ELISA, IHC-P .... Bcl2 antibody [bcl2/100/D5] - Carboxyterminal end, prediluted ...
http://www.abcam.com/index.html?t=6576&pt=1&c=299...

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BCL2 Antibody
Specific antibody for the gene product of BCL2, the protein B-cell lymphoma protein 2. Validated for specificity by gene-silencing with siRNA followed by
...
http://www.piercenet.com/products/Browse.cfm?fldID=FD12519F-...

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