Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17912028 |
This study aimed to explore, whether polymorphisms in BCL2, Cyclin D1, FAS, EGF and EGFR genes affect survival in a cohort of patients with squamous cell esophageal cancer treated with CT+RT with a view to identify the potential therapeutic targets. |
| 18023359 |
IL-10 modulated the pro-apoptotic capacity of TNF-alpha in chondrocytes as shown by the decrease in caspase activities and bax/bcl-2 ratio |
| 18182854 |
substitution of C-terminal tail or tail & adjacent loop of Bcl-2 with equivalent regions from Bak or Bax mutant resulted in association with mitochondria. change in subcellular localization of Bcl-2 chimeras triggered cells to undergo apoptotis |
| 18046447 |
our data do not support the use of the (-938C>A) BCL-2 polymorphism as a prognostic marker in CLL and argue against its postulated role in modulating Bcl-2 levels. |
| 18046449 |
GCs induce both pro- and anti-apoptotic BCL2 family member-dependent pathways, with the outcome depending on cellular context and additional signals feeding into the BCL2 rheostat. |
| 16215670 |
These findings imply that some of the biological functions of Bcl-2 may be attributed to their ability to inhibit anticancer agents-induced apoptosis through the sustained Akt activation. |
| 18334006 |
this study has found bcl-2 of no value as a prognostic marker in this group of serous ovarian tumors |
| 18162459 |
In thyroid glands of patients with Graves disease the regulation of Fas/Fas ligand/Bcl-2 favors apoptosis of infiltrating lymphocytes. |
| 17693666 |
Risk for head and neck squamous cell carcinoma may be assocated with single-nucleotide polymorphism in the promoter region. |
| 17959858 |
BCL2 protein levels in CLL reflect a complex interplay of transcriptional and posttranscriptional controls, but do not appear to be associated with the -938C>A promoter SNP. |
| 18037229 |
sHA 14-1 antagonizes anti-apoptotic Bcl-2 proteins and may represent a promising candidate for the treatment of drug-resistant cancers. |
| 18055344 |
BCL2 translocation is essential for the pathogenesis of follicular lymphoma in Thai patients |
| 17909078 |
a novel link between TLR4 and a calcium-dependent signaling cascade comprising CaMKIV-CREB-Bcl-2 that is essential for DC survival. |
| 11325850 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12133517 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 12161031 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12960134 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14714449 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16638864 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16733517 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16960146 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17207023 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17534194 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17557568 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17561354 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 17693666 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17908970 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17909067 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17912028 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18174230 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17960583 |
BCL2 functions as an activator of the AKT signaling pathway in pancreatic cancer. |
| 17916073 |
COX-2 and Bcl-2 may promote phaeochromocytoma malignancy, and these oncoproteins may be valuable surrogate markers of an aggressive tumour phenotype. |
| 18041310 |
Alterations in the expression of p53, survivn, and bcl-2 take place in a concerted fashion, implying that many of these cases may share common abnormalities. |
| 18059532 |
These findings suggest that downregulating CIAPIN1 could sensitize leukemia cells to chemotherapeutic drugs by downregulating MDR-1 and Bcl-2 and by upregulating Bax. |
| 18091321 |
study shows bcl-2 is occasionally expressed in pancreatic endocrine tumors |
| 18156504 |
genetic variation due to ethnicity may influence prognostic value in chronic lymphocytic leukemia |
| 18199533 |
t-Darpp promotes cancer cell survival by up-regulation of Bcl2 through Akt-dependent mechanism. |
| 17942410 |
interaction between the catalytic FKBP38 domain and the N-terminal CaM domain activates FKBP38 and, as a consequence, also regulates Bcl-2. |
| 17848408 |
overexpression of Bcl-2 may result in "oncogene addiction" of the cancer cell |
| 17516030 |
CDK11(p58) down-regulates Bcl-2 in pro-apoptosis pathway depending on its kinase activity, which elicits survival signal in hepatocarcinoma cells. |
| 17252199 |
Data suggest that cytoplasmic mutant p53 increases Bcl-2 expression in estrogen receptor-positive breast cancer cells. |
| 17913397 |
These data suggest that P1 promoter is the main driving force for transcribing the bcl-2 gene and P1 activity is modulated by M and P2 in a p53-dependent and -independent manner. |
| 18021997 |
Expression of antiapoptotic Bcl-2 protein occurs during the entire heart posttransplant period, being probably a preservative and adaptative response. |
| 17893875 |
Epo has a role in reducing expression of apoptosis-related proteins Bcl-2 and Bcl-10 in ovarian cancer cells |
| 17989874 |
After the addition of 20 microg/ml DDP or 100 microM DADS, siRNA targeting of the Bcl-2 gene specifically down-regulated gene expression in A549/DDP cells, increased spontaneous apoptosis, and sensitized cells to DDP and DADS. |
| 17893147 |
a caspase-9 signaling cascade induces feedback disruption of the mitochondrion through cleavage of anti-apoptotic Bcl-2, Bcl-xL, and Mcl-1 |
| 17785366 |
progesterone via progesterone receptor interacts with the bcl-2 promoter to induce its expression in leiomyoma tissue |
| 17908970 |
the AA genotype of the BCL2 (-938C>A) single-nucleotide polymorphism may play a role in increased survival in lymph node-negative breast cancer patients |
| 17978676 |
Diabetic human conjunctiva, with its inflammatory and cicatricial phenomena, is a privileged target for BCL2 protein apoptotic cell death. |
| 17434928 |
Cells over-expressing Bcl-2 showed evidence of increased genomic instability, consistent with the impairment of apoptosis in damaged cells. |
| 17785460 |
Study demonstrates that PKCepsilon forms a signaling complex and acts co-operatively with Akt to protect human vascular endothelial cells against apoptosis through induction of the anti-apoptotic protein Bcl-2 and inhibition of caspase-3 cleavage. |
| 17852408 |
IFN-alpha sensitivity of B-cell lymphomas depends on the presence or absence of BCL |
| 17981569 |
bcl2 and Caspase-3 have roles in Shikonin analogue (SA) 93/637 induced apoptosis of human U937 cells |
| 18006836 |
silencing of PrPc facilitates the activation of proapoptotic Bax by down-regulation of Bcl-2 expression, thereby abolishing the resistance of breast cancer cells to TRAIL-induced apoptosis |
| 17652637 |
Correlation of breakpoints with histology showed that major breakpoint region occur more frequently in grade 2 lymphomas. |
| 17848143 |
p53 and Ki-67, but not bcl-2, cyclin D1 or HER-2 may have roles in the process of tumor genesis in non-small cell lung carcinoma |
| 17825790 |
Therefore, these data support the hypothesis that CREB plays a critical role in the regulation of Bcl-2 expression in TCS-induced Hela cell death. |
| 17561354 |
There appears to be an influence of BCL2 ala43ala genotypes on esophageal cancer phenotype, particularly with regard to tumor location, which supports the theory of prevalence of site-specific genetic alterations |
| 17880809 |
We conclude that alteration in the expression of proapoptotic (Bax, Bak) and antiapoptotic (Bcl-2, Bcl-XL) proteins on surface of thyroid follicular cells may play a role in the pathogenesis of thyroid autoimmune disorders. |
| 17145812 |
The Bcl-2 expression was low and showed no significant difference between laryngeal papillomatosis and normal larynxes. |
| 17372162 |
in breast cancer, Bcl2 protein expression parallels its mRNA level, and it has a highly significant and independent prognostic relevance. |
| 17670745 |
a novel role for BAD in cell cycle regulation dependent upon its phosphorylation state and independent of the BAD/BCL2 interaction and apoptosis. |
| 17356300 |
HIV Tat protein increases Bcl-2 expression in monocytes which inhibited apoptosis induced by TRAIL. |
| 17360176 |
Researchers found increased Bcl-2 positive identification after neoadjuvant therapy in patients with colorectal cancer. |
| 17675494 |
Bcl-2 up-regulation is a homeostatic survival mechanism necessary for the manifestation of immunomodulatory effect of estrogen on human macrophages. |
| 17882791 |
p38 is necessary for Bcl-2-induced inhibition of apoptosis, induction of cell cycle arrest and accelerated senescence after DNA damage and serum starvation, but not after nocodazole treatment. |
| 17295204 |
The delay of tumor progression is apparently determined by the ability of Bcl-2-expressing tumor cells to extinguish the cell-damaging environmental stress signals and Bax activation, while its acceleration correlates with Bcl-2 loss. |
| 17575222 |
These data suggest that long-term androgen deprivation + radiotherapy should be used when either Bcl-2 or Bax is abnormally expressed. |
| 16690525 |
in diffuse large B-cell lymphoma, molecular alterations in ice, bcl-2, c-myc and p53 are present in hematopoietic cells from bone marrow as well as in primitive hematopoietic progenitors |
| 16840204 |
up-regulation of bcl-2 has a role in preferential survival of acute lymphoblastic leukemia cells at 33 degrees C |
| 17713095 |
p53 expression may have a role in the carcinogenesis of squamous cell cervical carcinoma whereas Bcl-2 expression has no role. Ki-67 expression can not be used in determining the aggressiveness of CIN lesions |
| 16988783 |
Bcl-2 is a common mediator of early apoptotic and necrotic events occurring at rates that are dependent on cellular factors accumulating over time |
| 17666167 |
Impaifred kinetics of Bax-GFP and Smac/DIABLO-GFP in caspase 8 and bid-silenced and Bcl-2-overexpressed breast cancer cells exposed to camptothecin. |
| 17701916 |
bcl-2 and p53 expression in neuroblastoma is related to DNA fragmentation |
| 17438366 |
BH3-only proeins and BH3 mimetics induce autophagy by competitively disrupting the interqction between BECN1 and Bcl-2/Bcl-X(L). |
| 17507655 |
Rho inactivation allows the activity of Rac to become dominant leading to stimulation of the phosphoinositide 3-kinase/Akt/IkappaB kinase/nuclear factor-kappaB prosurvival pathway. |
| 12270344 |
Immunohistochemical expression of this protein in squamous cell carcinomas from immunosuppressed renal transplant recipients and immunocompetent individuals. |
| 12686415 |
role in counterregulating mitochondrial protassium transport |
| 12835724 |
p50 and p52 homodimers can transactivate the bcl-2 promoter through association with Bcl-3; in breast cancer and leukemic cells (CLL), high NF-kappaB2/p100 expression was associated with high Bcl-2 expression |
| 12890751 |
Bcl-2 decreases the level of functional E-cadherin thereby interfering with junction formation. |
| 13130506 |
Sustained reduction of bcl-2 protein causes glioma cells to undergo marked morphological change, reduced in vitro growth, complete loss of tumorigenicity, and increased sensitivity to cisplatin. |
| 15203866 |
Assessment of Bcl-2 and Fas expression at diagnosis in acute leukemia (1) could predict responsiveness to induction chemotherapy in ALL but not in AML |
| 16243795 |
Loss of pSer70 Bcl-2 expression is closely linked to biological aggressiveness in colorectal tumors and represents a statistically significant molecular index for prognosis of patients with these tumors. |
| 15024706 |
normal, hyperplastic and neoplastic breast epithelial cells expressing the anti-apoptotic protein Bcl-2 are immature cells that form part of the stem-cell subpopulation |
| 15498929 |
Bcl-2 expression markedly enhanced spontaneous lung metastasis from orthotopically implanted primary tumors. |
| 16735440 |
We analysed the ability of human Bcl-2 to interact with and regulate the activity of nematode apoptosis proteins, and hypothesise that Bcl-2 might suppress nematode cell death by preventing EGL-1 from antagonising CED-9, rather than by inhibiting CED-4. |
| 12054739 |
TNF alpha dramatically reduced intracellular levels of Bcl-2, while Dex abrogated this reduction. |
| 12054916 |
Increased cytosol Ca(2+) and type 1 programmed cell death in Bcl-2-positive U937 but not in Bcl-2-negative PC-3 and Panc-1 cells induced by the 5-lipoxygenase inhibitor MK 886. |
| 12209955 |
overexpression of the Bcl-2 or Bcl-x(L) associated with the loss of apoptosis in breast cancer cells in vivo may account for their metastatic behavior |
| 14660675 |
up-regulation of uPAR expression by Bcl-2 in hypoxia is modulated by Sp1 DNA binding activity through the ERK signaling pathway |
| 14971737 |
Bcl-2 and bax molecules play a role in the regulation of apoptotic mechanisms in pituitary adenomas. |
| 15528355 |
Bcl-2 transgene promotes B cell accumulation in signaling-deficient B-cell maturation defect 1 (bcmd-1) mice, but formation of white pulp areas of the spleen and follicles in the lymph nodes is severely impaired. |
| 15541642 |
BCL2 expression is important for maintenance of hair follicle epithelial stem cells and formation of secondary hair germ |
| 12499093 |
The relationships and interactions between p53, Rb and bcl-2 immunostaining, clinical parameters and response to cisplatin-based chemotherapy were evaluated in the present study. |
| 12670866 |
This gene constitutively suppresses p53-dependent apoptosis in colorectal cancer cells. |
| 12819863 |
Importance of Bcl-2 as anti-apoptotic protein and mechanisms underlying its cytoprotective effects on pancreatic islets. |
| 15800682 |
The weak immunoreactive expression of p53, combined with a relatively strong expression of bcl-2 contributes to the characteristic slow progression of parathyroid adenoma |
| 15929186 |
Apoptosis-associated bcl-2 oncogene is abnormally expressed in gastric precancerous lesions |
| 16799010 |
An analysis of clinical outcome in 23 PIOL (primary intraocular lymphoma) patients revealed no significant association between bcl-2 t(14;18) translocations and survival or relapse. |
| 11877669 |
Bcl-2 expression is upregulated by VEGF in neuroblastoma cells. |
| 11877670 |
Bcl-2 expression is upregulated by IGF-I in neuroblastoma cells, which are thereby protected from starvation-induced apoptosis. |
| 14679209 |
bcl-2 mRNA contains an AU-rich element that functions in regulating bcl-2 stability |
| 17536310 |
immunoreactivity of p53, MDM2, WAF1, and BCL-2 were measured in soft tissue sarcomas cases consisting of 54 low-grade, 40 intermediate-grade, and 58 high-grade sarcomas |
| 11877266 |
Dysregulated bcl-2 expression does not play a significant pathogenetic role in most pediatric follicular lymphomas, but does identify a subset of patients in whom disease is often disseminated and more refractory to combination chemotherapy. |
| 14980220 |
the role of BCL-2 depends on its interaction with nuclear orphan receptor Nur77/TR3 |
| 16438077 |
This study aims to evaluate the expression of bcl-2, which is an antidote of apoptosis, and aims to evaluate the value of bcl-2 as a prognostic marker in papillary thyroid cancer |
| 16472763 |
beta amyloid-induced neurotoxicity occurs via apoptosis regulator BAX over-expression, bcl-2 down-regulation, and caspase-3 activation, first indicating that methionine 35 redox state may alter this cell death pathway |
| 16481323 |
BCL-2-overexpressing cells are sensitized to apoptosis by a pyrimidine-2,4,6-trione derivative |
| 16520895 |
Data suggest that prolaction-mediated induction of ornithine decarboxylase activity enhances expression of Bcl-2 strongly enough to bring about prolactin's anti-apoptotic function. |
| 11804688 |
overexpression appears to be an early event in lung tumorigenesis; may function as a potential biomarker for the development of NSCLC |
| 15057274 |
SRF-regulated Bcl-2 expression as a novel mechanism that is important for cell survival during early murine embryogenesis |
| 15124764 |
both Bak and Bcl-2 were found to be increased in correlation with an immune marker (beta2-microglobulin) in white and gray matter and plaque compared with corresponding cortical regions. |
| 15340216 |
We made an NG108-15 transfectant, Bcl-2(P2), that stably expressed human Bcl-2, and used it to test Bcl-2's effect on the serum-starvation-induced apoptosis in NG108-15 cells. |
| 15911345 |
Bcl-2 provided Purkinje cell protection from SV40 Tag-induced cell death. Interestingly, RotaRod behavioral analysis demonstrated that 'rescued' Purkinje cells degrade cerebellar function. |
| 12629413 |
Regulation of Bcl-2 expression by dihydrotestosterone in hormone sensitive LNCaP-FGC prostate cancer cells. |
| 16173075 |
overall survival of post-surgical pancreatic adenocarcinoma patients seemed to be improved with Bcl-2 and Bax expression |
| 12720100 |
results suggest that the expression of Bcl-2 protein and of adrenomedullin in invasive squamous carcinoma may play crucial roles in selecting carcinoma cells resistant to apoptosis and in promoting malignant progression |
| 14519627 |
Protects from apoptosis. when transfected into T cell from renal cell carcinoma. |
| 15634885 |
Apoptosis is blocked by human Bcl-2 in a mouse macrophage cell line and in primary mouse macrophages. |
| 16199534 |
studies suggested that acetylsalicylic acid -promoted Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity is mediated through down-regulating BCL-2 |
| 16575548 |
the ratio of Bax:Bcl-2 in the human oviduct increases significantly in the luteal phase consistent with cells undergoing apoptosis |
| 16820876 |
lysosomal damage by ATX-s10-PDT can initiate apoptotic response and this apoptotic pathway can be regulated by photodamage to Bcl-2 via mitochondrial damage |
| 17050165 |
Bcl-2 induced by functional regulation of G-protein coupled receptors protects from oxidative glutamate toxicity by increasing glutathione |
| 15593417 |
colocalization of Human papillomavirus type 16 E5 protein with the Bcl-2 antiapoptotic protein on intracellular membranes was established |
| 15720412 |
Expression of bcl-2 expression has no prognostic value for gastrointestinal stromal tumours. |
| 15901672 |
lack of role in sequestering proapoptotic Bak |
| 16007339 |
Expression of Bcl-2 in osteoblasts is important in regulating bone mass in development and in the normal aging process of bone. |
| 16638854 |
Bcl-2 is an independent predictor of breast cancer outcome and seems to be useful as a prognostic adjunct to the Nottingham Prognostic Index (NPI), particularly in the first 5 years after diagnosis. |
| 16636671 |
Bcl-2 expression in MCF7 cells stabilizes p53, induces phosphorylation of p53 serine 15 (p53pSer15) and inhibits MCF7 cell growth |
| 16707568 |
This study reveals a compartment-specific toxicity of PrP misfolding that involves coaggregation of Bcl-2 and indicates a protective role of molecular chaperones. |
| 16874461 |
Bcl-2 by competing with IP3R1 for the binding of PP1 can reduce the inositol trisphosphate-mediated calcium signal and protect cells from mitochondrial dysfunction and cell death. |
| 12170763 |
Expression of Bcl-2 eliminates selective advantages for p53-deficient cells in the tumor. |
| 12171774 |
REVIEW: Bcl-2 family members as prognostic indicators in AML. |
| 12431997 |
Improves oxidative phosphorylation and modulates adenine nucleotide translocation in mitochondria of cells harboring mutant mtDNA. |
| 12729794 |
Data show that overexpression of Bcl-2 in human Ms-1 cells inhibited not only the release of cytochrome c from mitochondria but also de novo ceramide synthesis induced by inostamycin. |
| 12533044 |
Chemotherapy induced Bcl-2 cleavage was blunted by inhibition of caspase activity in leukemia cells; however, coculture with bone marrow stromal cells resulted in reduced levels of 23 kDa Bcl-2. |
| 12960340 |
Transgenic mice over-expressing human Bcl-2 in myeloid cells exhibit markedly increased neutrophil accumulation and reduced bacteria counts in peritoneum following cecal ligation and puncture, consistent with an increased host response. |
| 15339676 |
Bcl-2 is over-expressed in CD34+ acute myeloid leukemia (AML); conversely, MDR1 is over-expressed in CD34- AML. |
| 15489891 |
overexpression does not affect apoptotic pathway triggered by the Fhit protein in lung cancer cell lines |
| 12617962 |
This study suggest that Bcl-2 modulates neuroprotective effects of calcineurin and that calcineurin inhibitors increase ischemic neuronal damage. |
| 12046064 |
Changes of NF-kB, p53, Bcl-2 and caspase in apoptosis induced by JTE-522 in human gastric adenocarcinoma cell line AGS cells: role of reactive oxygen species. |
| 12118096 |
Failure of up-regulation in proximal tubular epithelial cells of donor kidney biopsy specimens is associated with apoptosis and delayed graft function |
| 12637332 |
SCF up-regulates Bcl-2 and Bcl-X L in erythroid precursors and exogenous expression of these proteins protects erythroblasts from caspase activation and death induced by chemotherapeutic agents. |
| 12722479 |
BCL2 antiproliferative effect in E1A + c-Ha-ras-transformants was not associated with alterations in Cdk2, cyclins E and A content. |
| 15123638 |
Data suggest that the internal ribosome entry site-mediated translation of BCL-2 may enable the cell to replenish levels of this critical protein during cell stress, when cap-dependent translation is repressed. |
| 16010987 |
Bcl-2 is antagonized by dynamin-related protein (Drp1) and mitochondrial fission protein (hFis1). |
| 16675913 |
Clusterin and bcl-2 are upregulated in laryngeal carcinomas and their expression is related to invasiveness of these tumors. |
| 15345651 |
Mouse hearts overexpressing transgenic human BCL2 have a slower rate of decline in ATP during ischemia & reduced acidification. Oligomycin & Bcl-2 affect a common pathway. Bcl-2 modulates mitochondrial physiology & function. |
| 17241114 |
These findings suggest that neuroprotection by simvastatin is dependent on the drug's previously unexplored and important effect of up-regulating Bcl-2. |
| 17516614 |
Patients with active and inactive juvenile-onset systemic lupus erythematosis have a different profile of Fas and Bcl-2 expression. |
| 14737118 |
determination of divergent sequences to facilitate design of specific inhibitors |
| 12217802 |
bcl-2/Jh lymphomas show molecular heterogeneity and that bcl-6 and p53 mutations may be acquired during the evolution of such lymphomas |
| 12036852 |
compared rates of bcl-2 translocation in follicular lymphoma across geographic regions |
| 14767525 |
Bax and Bcl-2 proteins are elevated after treatment with cladribine, cyclophosphamide, mitoxantrone, and combination chemotherapy |
| 15245329 |
direct interaction of Bcl-2 with SERCA may be involved in the regulation of apoptotic processes in vivo through modulation of cytoplasmic and/or endoplasmic reticulum calcium levels required for the execution of apoptosis |
| 15329319 |
Bcl-2 is significantly expressed in squamous cell carcinoma compared to those with transitional cell carcinoma type in the presence of schistosomiasis. |
| 15763593 |
expression of ESRA, bcl-2 and c-myc gene expression in fibroadenomas and adjacent normal breast is related to nodule size, hormonal and reproductive features |
| 11949842 |
expression of apoptosis-regulating proteins p53, Bcl-2, and Bax in primary resected esophageal squamous cell carcinoma |
| 11949843 |
Expression of p53 and bcl-2 proteins in acute leukemias: an immunocytochemical study |
| 12540563 |
H. pylori-induced ERK1/2 activation, especially by the cagA(+) H. pylori strain, may play a protective role against gastric epithelial cell apoptosis partially through maintenance of bcl-2 gene expression |
| 15733859 |
Bcl-2 interacts with FKBP38 through the unstructured loop, and the interaction appears to regulate phosphorylation in the loop of Bcl-2 |
| 16204228 |
catalase has a critical role in CSF-independent survival of human macrophages via regulation of the expression of BCL-2 and BCL-XL |
| 16566921 |
Results suggest that Ubc9 might regulate bcl-2 expression through the ER signaling pathway, which ultimately contributes to the alterations of drug responsiveness and tumor growth. |
| 16855163 |
anti-beta-2 glycoprotein I antibodies react with trophoblast cells and reduce the Bcl-2/Bax ratio, but without any clear apoptotic effect |
| 17404013 |
The level of bcl-2 expression could be a valuable predictor of tumor behavior and disease outcome. |
| 11983915 |
bcl-2 overexpression promotes myocyte proliferation |
| 15561778 |
Bcl-2 overexpression leads to the induction of activated signal transducer and activator of transcription 3 (STAT3) and to the induction of SOCS3, which may contribute to the pathogenesis of follicular lymphoma. |
| 16166262 |
BCL2 repression by miR-15 and miR-16 microRNAs induces apoptopsis in a leukemic cell line model. |
| 12162425 |
Depletion of Bcl-2 by an antisense oligonucleotide induces apoptosis accompanied by oxidation and externalization of phosphatidylserine in NCI-H226 lung carcinoma cells |
| 12207028 |
Overexpression affects mitochondrial structure and function |
| 12112824 |
Bcl-2 protein expression in breast cancer |
| 12684626 |
over-expression of BCL2 is associated with muscle invasive transitional cell carcinoma of the bladder. |
| 12937123 |
Overexpression of bcl-2 and bcl-xL leading to prolonged survival of mast cells may contribute to the pathogenesis of mastocytosis. |
| 14689061 |
bcl-2 protein positivity did not affect significantly the AgNOR distribution either in p53 protein positive or p53-negative cases of leukemia patients. |
| 14754534 |
Bcl-2 level in asthmatic children is higher than control. |
| 15351796 |
evaluated the expression of Bcl-2, Bax and Bak in patients with Graves Disease (GD); findings suggest that the differential expression of Bcl-2 family proteins in both thyrocytes and lymphoid follicles may be involved in the pathology of GD |
| 15367432 |
spontaneous T-cell reactivity against Bcl-2 in peripheral blood from patients suffering from unrelated tumor types |
| 15572421 |
PCNA expression induces apoptosis by up-regulating cleaved caspase-3 and poly adp ribose polymerase expression and down-regulating Bcl-2 protein expression in leiomyoma cells. |
| 15840562 |
an imperfect purine/purine/pyrimidine triplex likely forms at the bcl-2 major breakpoint region of the t(14;18) translocation |
| 16132718 |
overexpressing an antioxidant gene such as GPX1 in endothelial cells is able to change the basal mRNA and protein Bax levels without affecting those of p53 and Bcl-2 |
| 16246184 |
Suppression of Bax and overexpression of Bcl-2 protein is an early event in gastric tumorigenesis, before gastric dysplastic |
| 16227396 |
Bcl-2-mediated apoptosis resistance in human colon cancer cells. |
| 11871856 |
Using a recombinant vaccinia virus expressing protooncogene Bcl-2, we demonstrate opposite effects of the expressed Bcl-2 in two cell lines: apoptosis induction in BSC-40 cells and apoptosis prevention in HeLa G cells. |
| 12532420 |
Bcl-2 staining was not observed in gastric carcinoma cells without E-cadherin mutations, but was detectable in 5 of 16 tumors with E-cadherin mutations (31.3%), a difference that was not statistically significant (p = 0.13). |
| 12756585 |
The detected pattern of the p53/ bcl-2 ratio in hypertrophic actinic keratosis suggests important role for another gene: the proapoptotic gene bax. |
| 12901880 |
BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis. |
| 15803126 |
The c-bcl-2 presence will have less mutations at A and T in B cells mutating their immunoglobulin genes. |
| 15302859 |
Bcl-2 interacts with activated Bax during apoptosis in an effective manner to neutralize the proapoptotic activity of Bax. |
| 14627346 |
possible deregulation of the mechanisms that control bcl-2 expression in high-grade and advanced-stage colorectal carcinomas. |
| 15638363 |
The optic nerve axons in glaucomatous eyeballs showed statistically significant higher Bax protein expressions than those of Bcl-2 proteins. |
| 16139338 |
Spontaneous apoptosis is reduced in the endometrium of unexplained-infertile women, and is associated with the changed Bcl-2:Bax ratio |
| 12481899 |
BCL2 expression is not dependent upon the level of BAX epxression; reduction of BCL2 level activates p53-dependent apoptototic pathway. |
| 12032828 |
NF-kappaB activates Bcl-2 expression in t(14;18) lymphoma cells. |
| 12032841 |
Involvement of nuclear factor-kappa B, Bax and Bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cells |
| 12721288 |
a novel role in cell fate decisions /during hematopoietic differentiation/ beyond cell survival |
| 12721767 |
High levels of Bcl-2 prevent accumulation of (99m)Tc-MIBI in breast tumour cells. |
| 12581249 |
In adenocarcinoma, the expression of bcl-2 is associated with improved survival compared with bcl-2 negative patients. |
| 15735709 |
Arsenic trioxide might exert cell killing in part by inducing Bax activation through a Bcl-2-suppressible pathway in hematopoietic cells that is caspase independent and intracellular ROS regulated |
| 15757977 |
BCL2-mediated apoptosis appears to play a significant role in pathogenesis of laminin alpha2 deficiency |
| 11867266 |
analyzed expression in leiomyomas and myometrium from fertile and menopausal women |
| 14572466 |
Bcl-2 phosphorylated at serine-70 plays a critial role in the translocation of Bax from the cytosol to the mitochondria in nitric oxide-induced neuronal apoptosis. |
| 12165497 |
Fibroblast-like synoviocytes from rheumatoid arthritis patients express functional IL-15 receptor complex: endogenous IL-15 in autocrine fashion enhances cell proliferation and expression of Bcl-x(L) and Bcl-2. |
| 12530303 |
Bcl-2 protein expression in developing human brain |
| 15034060 |
Reduced levels of Bcl-2 may play an important role in the increased sensitivity to apoptosis of HIV-specific CD8+ T cells. |
| 16568081 |
overexpression of Bcl-2 is one of the key mechanisms to give neuroblastoma cells the resistance against ATRA-mediated apoptosis |
| 16648655 |
Finds a statistical significance for Bcl-2, Bax, and apoptosis with H. pylori status in gastric cancer patients in Egypt |
| 16733517 |
BCL-2 variants may be associated with a decrease in prostate cancer susceptibility. |
| 16839413 |
The Bcl-2 protein expression has a close correlation with p27 and p53 protein expressions and the proliferation activity determined by MIB-1 counts in invasive ductal carcinoma of the breast. |
| 16850164 |
Asbestos may affect the human immune system through STAT3 activation and Bcl-2 overexpression. |
| 16998187 |
Molecular model of the major G-quadruplex structure formed in the BCL2 promoter provides insights for its loop conformations and interactions with the core tetrad structures. |
| 16982461 |
Increased serum levels of Bcl-2 is associated with advanced stage non-small cell lung cancer |
| 17074584 |
Patients carrying BCL2 gene rearrangements showed longer telomere length (4.19 +/- 0.14 kb) than those without (3.51 +/- 0.14 kb; P = 0.05). |
| 17325632 |
BCL-2 expression was investigated depending on the site of the tissue material sample and the final histopathological result. |
| 17473827 |
Upregulation of bcl-2 may play a major role in therapy resistance. |
| 12140755 |
Regulation of bcl-2 gene expression in human breast cancer cells by prolactin and its antagonist, hPRL-G129R. |
| 12189556 |
Retinoids cause apoptosis in pancreatic cancer cells via activation of RAR-gamma and altered expression of Bcl-2/Bax. |
| 12393707 |
Forced expression of STAT5a in human cord blood-derived CD34+ cells enhanced expression Bcl-2 and p21(WAF/Cip1), suggesting they may be important in STAT5a-mediated eosinophil differentiation. |
| 11929874 |
A functional role for the B56 alpha-subunit of protein phosphatase 2A in ceramide-mediated regulation of Bcl2 phosphorylation status and function |
| 11986946 |
The coexpression of the apoptosis-related genes bcl-2 and wt1 in predicting survival in adult acute myeloid leukemia. |
| 12751031 |
Role in polyclonal proliferation and apoptosis of CCR5-positive T-lymphocytes in patients with HIV type-1 infection. |
| 14529662 |
The immunodetection of both p53 and bcl-2 proteins in squamous cell carcinoma of the uterine cervix can be used as an independent diagnostic marker for cervical cancer associated with HPV infection. |
| 11999565 |
BCL-2 overexpression was noted in 29.4% cases of T-cell lymphoblastic lymphoma cases but was not correlated with higher rate of relapse |
| 14966123 |
the Ca(2+) spike, mitochondrial Bcl-2 presensitization, and subsequent Delta psi(m) transition, Bax translocation, and ROS generation are important upstream signals for cytochrome c release upon stimulation by a Bcl-2 inhibitor. |
| 15156398 |
Overexpression of antiapoptotic proteins Bcl-2 and Bcl-X(L) and down-regulation of caspase-3 activity may be associated with cisplatin resistance in human ovarian cancer. |
| 15484294 |
aberrant ratio of bcl-2 to bax protein expression may be involved in the course of tumorigenesis of cholangiocellular carcinoma |
| 11861644 |
overexpression in regulatory volume decrease. Enhancing swelling-activated Ca(2+) entry and Cl(-) channel activity |
| 15584904 |
HGF and BCL-2 family proteins use a furin-dependent pathway to promote invasion via TGF-beta and MMP in human malignant glioma cells and the pro-invasive properties of TGF-beta require furin- dependent MMP activity. |
| 15720419 |
Bcl-2 positivity identified a subgroup with invariably fatal disease in the high-risk IPI (International Prognostic Index) patients. |
| 15830715 |
Expression of Bcl-2 is significantly higher in squamous cell carcinomas than in verrucous penile carcinomas. |
| 15817479 |
Blockage of the mitochondrial permeability transition pore and caspase-9 demonstrated that Bcl-2-modulated caspase-2 activity occurred upstream of mitochondria |
| 15965276 |
Significantly higher Bcl-2 levels were associated with advanced lung cancer patients |
| 16181427 |
Transducible loop deleted Bcl-2 increases survival of cortical neurons after trophic factor withdrawal and also rescues neural cell lines from staurosporine-induced death. Supports concept of protein transduction of Bcl-2 constructs for neuroprotection. |
| 16273250 |
Bcl-2 expression was associated with better overall survival and appears to be the key biological factor influencing clinical behaviour. |
| 16642033 |
Data suggest that Bcl-2 functions as an inhibitor of mitochondrial permeabilization by changing conformation in the mitochondrial membrane to bind membrane-inserted Bax monomers and prevent productive oligomerization of Bax. |
| 16717086 |
PP2A-mediated dephosphorylation of BCL-2 is required to protect BCL-2 from proteasome-dependent degradation, affecting resistance to ER stress |
| 16777355 |
the bcl-2 mbr possessed regulatory function that was related to special AT-rich sequence-binding protein 1 (SATB1). |
| 16761743 |
bcl2 and ROS1 oncogene expression in meningiomas are not concurrent and neither can be ascribed to any histologic subtype or grade of tumor. |
| 17082179 |
repression of BCL2 transcription is the single essential consequence of targeting the MIZ-1 pathway during apoptosis induction, which explains a copperative interaction between c-MYC and BCL2 |
| 17310847 |
Siatistically significant value in assocation with survival or event-free survival in head and neck squamous cell carcinoma. |
| 17418785 |
Antiapoptotic proteins Bcl-2 and Bcl-X(L) bind and suppress NALP1, reducing caspase-1 activation and interleukin-1beta (IL-1beta) production. |
| 11804283 |
OVEREXPRESSION OF BCL-2 IS ASSOCIATED WITH POOR SURVIVAL IN PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA PATIENTS |
| 12759537 |
results demonstrated significant positive staining of Bcl-2 in the salivary tumorigenic tissue, but not in the surrounding non-tumorigenic tissue, pointing to a biological role in the tumorigenic process |
| 12698366 |
results showed that Fas and/or Fas-Ligand, Bcl-2, and tissue transglutaminase may be involved in apoptotic pathways leading to mucosal atrophy in children with coeliac disease |
| 15314290 |
The apoptotic effect of 11-hydroxy-15-oxokaur-16-en-19-olic acid could be significantly offset by over-expression of Bcl-2 in colon cancer cells. |
| 15478112 |
Results describe the expression of Bak and Bcl-2 in primary human breast cancers. |
| 15492114 |
Retinoic acid-induced apoptosis is a consequence of cellular differentiation, which leads to nucleolin down-regulation and bcl-2 mRNA instability. |
| 15837573 |
Transplantation with mouse embryo stem (ES) cells overexpressing human Bcl-2 increases the survival of transplanted ES cells, neuronal differentiation, and functional outcome in ES-transplanted rats after severe focal ischemia. |
| 16469847 |
results indicate that GATA4 positively regulates cardiac Bcl2 gene expression in vitro and in vivo |
| 14612291 |
pancreatic carcinoma expressed a high positivity for bcl-2; findings suggested that the overexpression of bcl-2 is related to the carcinogenesis and progression of human pancreatic carcinoma. |
| 15467428 |
Downregulation of Bcl-2 protein is associated with breast disease |
| 15467450 |
These data show that JNK activation provides a molecular linkage from microtubule damages to the mitochondrial apoptotic machinery |
| 16358373 |
The expression of bcl-2 and p53 represent biological characteristics of colorectal carcinomas. |
| 15280201 |
Bcl-2 overexpression led to reduced cytochrome c-mediated caspase-9-dependent cardiomyocyte apoptosis and local inflammation in cardiac allografts during ischemia-reperfusion injury and also led to reduced immune responses |
| 12583439 |
Bax, Bcl-2, fas and Fas-L antigen expression in human seminoma: correlation with the apoptotic index. |
| 14999286 |
a stable non-B-DNA structure in the human genome appears to be the basis for the fragility of the Bcl-2 major breakpoint region, and the RAG complex is able to cleave this structure |
| 12070027 |
Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-x(L) is an essential survival protein of human myeloma cells. |
| 15263017 |
Bcl-2 and InsP3Rs were detected together in macromolecular complexes, inhibiting InsP3R activation and thereby regulating InsP3-induced calcium release from the ER. |
| 12754350 |
p53 gene and msh2 expression in recurrent glioblastoma multiforme |
| 11776759 |
BCL2 antisense transcripts decrease intracellular Bcl-2 expression and sensitize LNCaP prostate cancer cells to apoptosis-inducing agents. |
| 15225643 |
Extracellular signal related kinase and protein phosphatase 2A are physiological regulators of Bcl-2 phosphorylation, and these enzymes exert an influence on the anti-apoptotic function of Bcl-2. |
| 16148027 |
Bax, Bad, and Bim are upregulated, while Bcl-2 is downregulated in human neuroblastoma cells treated with propargylamine |
| 11855781 |
GM-CSF-driven apoptosis, but not TNF-driven apoptosis was reversibly associated with bcl-2-expression (bcl-2-dependent mechanism)in acute lymphoblastic leukaemia and non-Hodgkin's lymphoma in children. |
| 11959101 |
Bcl-2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes. |
| 12510149 |
BCL-2 has a role in prostate carcinogenesis and cancer progression [review] |
| 12613529 |
Abnormally migrating bands on SSCP gels were identified only in 4/24 samples, providing strong support for the notion that in FL the translocated bcl-2 coding region is not targeted by somatic hypermutation. |
| 15754411 |
COX-2 may regulate expression of apoptosis suppressor gene (bcl-2) through interaction of tumor cells and stromal cells |
| 16545683 |
Overexpression of Bcl-2 protected primary fibroblasts against oxidative stress-mediated reduction in cell proliferation, but did not prevent premature senescence. |
| 16841088 |
STAT3 activation by IL-6 provides an antiapoptotic advantage in human cord blood cells CD34+ cells, essentially owing to the expression of bcl-2. |
| 17188136 |
p53 and Ki-67 were expressed with increasing frequency, and bcl-2, p21, and mdm-2 with decreasing frequency in thyroid carcinoma progression. p27 and cyclin D1 were expressed in <15% of cases, with a trend toward decreasing expression. |
| 17272502 |
Kringle 5 of human plasminogen has a role in autophagic survival by up-regulating Beclin 1 and complexing Bcl-2 to Beclin 1 |
| 12477721 |
This protein, via its BH4 domain, blocks apoptotic signaling mediated by mitochondrial Ras. |
| 12477729 |
This gene on the endoplasmic reticulum regulates Bax activity by binding to BH3-only proteins. |
| 11956602 |
expression in pelvic lymph nodes and primary tumors in early stage cervical carcinomas |
| 12031912 |
overexpressed in acute myeloid luekemia while translocations associated with this gene are absent |
| 12234263 |
Bcl-2-mediates regulation of CD69-induced apoptosis of human eosinophils. |
| 14724650 |
Bcl-2 overexpression is associated with B-cell leukemia and lymphoma |
| 11877309 |
the first report of partial trisomy 3 and Bcl-2 overexpression in type II cryoglobulinemic vasculitis associated with HCV infection |
| 12186923 |
role in modulating HIV-1/monocyte-derived macrophage-induced neuronal apoptosis |
| 15033793 |
Reduced gastric Bcl-2 level may be the main pathogenic mechanism of H. pylori-induced apoptosis in gastric epithelial cells. |
| 15033825 |
Expression of this apoptosis-related protein may be a useful marker in cervix cancer development. |
| 12086875 |
Bcl-2-dependent modulation of Ca(2+) homeostasis and store-operated channels in prostate cancer cells |
| 11940482 |
Apoptotic index (includes nick-end labeling) and bcl-2 do not correlate with key clinical data (prognosis and blood counts at diagnosis) in patients with myelodysplastic syndrome, whie p53 protein levels do. |
| 15235941 |
Down regulation in Hep3B cell line in the presence of Ni(2+). |
| 15274378 |
Advanced stage non-small cell lung tumors or tumors with lymph node metastasis were analyzed, a more favorable survival was noted in patients with bcl-2-positive tumors than those with bcl-2-negative tumors. |
| 12400004 |
levels of Bcl-2 were higher in the metastatic sublines than in parental breast cancer cells, which correlated with the activation of Stat3, but not with the expression/activation of bcl-2 transcription factors (CREB and WT1). |
| 12439925 |
A very low mRNA level was indicated at bax, bcl-2 and bcl-xL in hepatocellular carcinoma tissues in contrast to normal liver. |
| 12702730 |
biochemical and functional mechanisms regulating the ARE-dependent degradation of bcl-2 mRNA |
| 15375594 |
Anti-apoptotic factors, Bcl-2 and Bcl-xL, were significantly decreased in epithelial cells under a hypoxic condition as assessed by Western blotting |
| 15633216 |
NS-398 significantly inhibits the proliferation and induces apoptosis of hepatoma cells, which may involve decrease of BCL-2 expression. |
| 15619620 |
Here we demonstrate that the Bcl-2-mediated suppression of hMSH2 expression results in a reduced cellular capacity to repair mismatches. |
| 16133992 |
During tuberculosis, predisposition of CD4 T-cell subsets to apoptosis may involve both low expression of Bcl-2 and excessive expression of transforming growth factor (TGF)-beta, tumor necrosis factor(TNF)-alpha, and Fas ligand (FasL). |
| 16194898 |
We present here a case of Follicular Lymphoma with leukemic presentation and a complex translocation involving the IgH, BCL2 and BCL6 loci |
| 16195370 |
IL-1Ra, Bcl-2, and iNOS are upregulated and counter the proinflammatory and proapoptotic effects of ischemia-reperfusion |
| 16228292 |
Bcl-2 has a role in cell death, apoptosis, and cytochrome c release independent of p53 |
| 16443602 |
WT p53, but not tumor-derived mutants, bind to BCL2 via the DNA binding domain and induce mitochondrial permeabilization. |
| 16533178 |
Bcl-2 expression appears significantly (p<0.005) more often in cases of mild colonic dysplasia (61.1%) compared to inflammatory-regenerative mucosa (14.8%). |
| 16541314 |
BCL2 has a role in growth of breast cancers with reduced capability of distant colonization |
| 16554306 |
Bcl2, in addition to its survival function, may also suppress DNA repair in a novel mechanism involving c-Myc and APE1, which may lead to an accumulation of DNA damage in living cells, genetic instability, and tumorigenesis |
| 16984978 |
The cooperative effects of phenotypes determined by mdm-2, p53, and bcl-2 expression may predict survival in patients with muscle-invasive TCC of the bladder |
| 17118768 |
In CD19+ B-cell chronic lymphocytic leukemia (B-CLL) cells of untreated patients, Bcl-2 showed over expression compared with CD19+ cells of healthy donors. |
| 17191123 |
These findings indicate that RTN3 is directly involved in the endoplasmic reticulum-constituents trafficking events through dually acting as an essential and important ER-stress sensor, and a trigger for the Bcl-2 translocation. |
| 17203183 |
pro-apoptotic Bax/Bcl-2 are upregulated in human leukemic HL-60 cells after treatment with ethyl acetate extract of Chinese medicinal herb Sarcandra glabra |
| 17379544 |
In normal HeLa cells, ectopic overexpressed Bcl-2 reduced cell apoptosis induced by overexpressed RTN3. results suggest that RTN3 could bind with Bcl-2 and mediate its accumulation in mitochondria, which modulate the anti-apoptotic activity of Bcl-2. |
| 17426248 |
18q21-23 copy number will be a clinically relevant predictor for sensitivity of SCLC to Bcl-2 family inhibitors. The 18q21-23 genomic marker may have a broader application in cancer because Bcl-2 is associated with apoptosis evasion and chemoresistance. |
| 11759059 |
an elevated bcl-2/bax ratio in rectal carcinoma tissue specimens suggests increased tumor resistance to adjuvant radiotherapy |
| 12095980 |
N-cadherin signal transduction upregulates Bcl-2 |
| 12025227 |
increased expression in renal cell carcinoma associated with minimal apoptosis levels; may play role in progression of renal cell carcinomas and resistance to treatment |
| 11964319 |
Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia. |
| 12036886 |
Expression levels of apoptosis-related proteins caspase 3, Bcl-2, and PI9 predict clinical outcome in anaplastic large cell lymphoma. |
| 12938158 |
Results show that shear stress-induced nitric oxide is associated with decreased expression of bcl-2. |
| 14628086 |
Abnormal Bcl-2 and Bax protein bands after induction therapy in AML patients may be considered as factors associated with unfavorable clinical outcome. |
| 15026553 |
Bcl-2 downregulation has a role in cisplatin resistance in human small cell lung cancer cells |
| 15243561 |
bcl-2 oncogene has not shown to be a prognostic factor for laryngeal squamous cell carcinoma of the supraglottic larynx. |
| 15314639 |
Down Regulation of BCL2 protein is associated with benign prostatic hyperplasia |
| 15605273 |
Skp2 in tumor cells suppresses apoptosis through Bcl-2 expression |
| 15716988 |
frequency and chromosomal features of this der(8)t(8;14;18) in a series of acute leukaemias and malignant lymphomas |
| 15826766 |
Inhibition of bcl-2 expression may be an attractive therapeutic strategy in RCC tumors with high bcl-2 expression. |
| 15849194 |
Pak1-dependent Raf-1 phosphorylation regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association |
| 15876860 |
in cells synchronized at the onset of mitosis, Bcl-2 is present in a complex with nucleolin, cdc2 kinase and PP1 phosphatase |
| 12515824 |
Bcl-2 lacks a signal for the mitochondrial outer membrane and therefore localizes to several intracellular membranes |
| 12420213 |
one possible mechanism by which BCL-x(L) and BCL2 delay cell cycle entry may be the inhibition of Myc activity through the elevation of p27. |
| 15303767 |
bcl-2 expression is low in large non-polypoid colonic neoplasms |
| 16186627 |
Data evaluate and compare the bcl2, bax, and nestin patterns in the frontal cortices of Alzheimer and multiple-infarct dementia patients, and in normal aging. |
| 16186795 |
Oct-2, therefore, acts as a cell survival factor in t(14;18) lymphoma cells by directly activating the antiapoptotic gene bcl-2. |
| 12215338 |
Nitric oxide may be involved in the endometrial apoptotic process, whose control may be related predominantly to the changes of Bcl-2 expression |
| 15149157 |
mechanisms other than p53 may play a role in the regulation of bcl-2 expression in endometrial carcinoma |
| 15149158 |
survivin, p53, and bcl-2 are elevated in breast carcinoma but not ductal intraepithelial neoplasia |
| 15907209 |
Maspin overexpression modulates tumor cell apoptosis through the regulation of Bcl2 family proteins |
| 11815602 |
Fibroblast growth factor-2 induces translational regulation of Bcl-XL and Bcl-2 via a MEK-dependent pathway: correlation with resistance to etoposide-induced apoptosis |
| 12214154 |
During vascular endothelial cell apoptosis, high initial expression of Bcl-2 protein was significantly downregulated by IFN-gamma, but less so by TNF-alpha. |
| 16308474 |
We aimed to investigate the expression pattern of p53, Bcl-2 and C-Myc in colorectal cancer(CRC)tissues obtained from Egyptian colorectal cancer patients divided in two different groups, associated with and without Schistosoma mansoni. |
| 14699151 |
interaction of bcl-2 with paxillin plays an important role during nephrogenesis |
| 15115329 |
Increased bcl-2 protein expression in cells of 5-8 wk human embryos was found. |
| 12480939 |
Bcl-2 controls caspase activation following a p53-dependent cyclin D1-induced death signal |
| 12513829 |
Bcl-2 may be involved in protecting against CD95-mediated apoptosis of cord blood CD34(+) cell. |
| 15051039 |
Bcl-2 protein was expressed more frequently and more strongly in uterine leiomyomas compared with leiomyosarcomas and smooth muscle tumors of uncertain malignant potential (STUMP) |
| 15545228 |
p53, bcl-2 and telomerase have roles in progression of Egyptian breast cancer patients |
| 11856759 |
AUF1 binds in vitro to bcl-2 mRNA; involvement of AUF1 in the ARE/AUBP-mediated modulation of bcl-2 mRNA decay during apoptosis |
| 11908736 |
REVIEW: gene expression regulation and role of bcl-2 in cell survival and cell cycle control in early hematopoiesis |
| 15544840 |
annexin I is regulated by an anti-apoptotic Bcl-2 protein in TNF-alpha-induced renal apoptotic events |
| 12694817 |
Patients having radical prostatectomy after radiotherapy had significantly higher Bcl-2 overexpression than patients having surgery as the initial treatment. Changes in the apoptotic pathway may be important in local recurrence after radiotherapy. |
| 14698203 |
The expression of estrogen receptor alpha, progesterone receptor and of Bcl-2 protein changed parallel with that of Akt protein in leiomyoma and myometrium. |
| 12579337 |
BCL2 expression was determined in doxorubicin resistant gastric carcinoma lines. |
| 12970736 |
We conclude that C/EBPalpha and C/EBPbeta contribute to the deregulated expression of Bcl-2 in t(14;18) lymphoma cells |
| 11642719 |
expression is related to apoptosis in thymus |
| 11988841 |
conformational change of Bcl2 due to association with peptidyl prolyl isomerase can contribute to irreversible apoptotic signaling. |
| 15261486 |
This review focuses on the mechanisms by which anti-apoptotic Bcl-2 family members control the permeability of the mitochondrial membrane and influence other aspects of mitochondrial function after brain ischemia. |
| 12151395 |
Inactivation of p21WAF1 sensitizes cells to apoptosis via an increase of both p14ARF and p53 levels and an alteration of bax and this protein ratio |
| 15196944 |
downregulation assists GD3 synthase's apoptotic effect on ECV304 cells |
| 15577328 |
Increase in serum bcl-2 is associated with melanoma |
| 15657349 |
Gossypol induced complete cytochrome c release from mitochondria, increased caspases-3 and -9 activity, and caused apoptotic death without affecting protein levels of Bcl-2 and Bcl-X(L.) |
| 15657350 |
Gossypol is a potent and novel therapeutic able to overcome apoptosis resistance by specifically targeting the activity of antiapoptotic Bcl-2 family members. |
| 15832769 |
p53, Bax, Bcl-2 and Mdm2 mRNA expression levels correlate with the malignant transformation of the uterine cervix |
| 15880952 |
role of COX-2 in regulating the degree of apoptosis by modulating bcl-2 protein in benign and malignant parotid gland tumors |
| 15811121 |
Bcl-2-positive dendritic cells in epidermis of inverted follicular keratoses. Keratinocyte bcl-2 staining was significantly higher in seborrheic keratoses(SKs). Bcl-2 may be increased in SKs as anti-apoptotic mechanism. |
| 15981087 |
in the germinal centers, most T cells are Bcl-2(-); most CD4(+) T cells are Bcl-2(-), while nearly 100% of the CD8(+)T cells are Bcl-2(+). The Bcl-2 downregulation by both B and CD4(+) T cells suggests these two subsets may undergo a selection process |
| 16533807 |
AP-2alpha induces apoptosis by down-regulating Bcl-2 and utilizing a bax/cytochrome c/Apaf1/caspase 9-dependent mitochondrial pathway |
| 16714000 |
down regulation of MAD2 could promote the drug resistance of gastric cancer cells and inhibit anticancer drugs induced-apoptosis by upregulating Bcl-2 and interfering the mitochondrion apoptosis pathway |
| 17015762 |
down-regulation of the neuropilin-1 transcripts by short interfering RNA caused spontaneous synoviocyte apoptosis, which was associated with both the decrease in Bcl-2 expression and the increase in Bax translocation to mitochondria. |
| 17259174 |
Bcl2 suppression of MMR may occur in a novel mechanism by directly regulating the heterodimeric hMSH2-hMSH6 complex, which potentially contributes to genetic instability and carcinogenesis |
| 17290286 |
These results suggest that failure of stress-induced downregulation of Bcl-2 underlies resistance of senescent human diploid fibroblasts to apoptosis. |
| 17301078 |
overexpression of Bcl-x(L) or Bcl-2 in PC12 cells markedly suppressed brefeldin A-induced activation of caspases and resulting cell death. |
| 17439414 |
Bcl-2 RNA silencing in transfected HepG2 cells induced apoptosis and increased sensitivity of cells to 5-FU and 10-hydroxycamptothecin. |
| 17464868 |
Bcl-2 expression was up-regulated in cervical carcinoma (both adenocarcinomas and squamous cell cancers) associated with humanpapillomavirus (HPV) infection |
| 17616686 |
BCL2 repression by the tumor suppressor activity of the lysyl oxidase propeptide inhibits transformed phenotype of lung and pancreatic cancer cells |
| 12000759 |
ionomycin-induced calpain activation promotes decrease of Bcl-2 proteins thereby triggering the intrinsic apoptotic pathway |
| 12452037 |
expression of telomerase genes (hTR, hTRT) and apoptosis related genes (p53, bcl-2) in mammary atypical ductal hyperplasia |
| 11839683 |
Protein kinase A RIalpha antisense inhibition of PC3M prostate cancer cell growth: Bcl-2 hyperphosphorylation, Bax up-regulation, and Bad-hypophosphorylation |
| 12879322 |
bcl-2 and bcl-6 proteins may play a role in the pathogenesis of transitional cell carcinoma, and bcl-6 expression reflects histopathologic grade. |
| 14764541 |
a selective decrease in Bcl-2 expression was seen in myeloid progenitor cells of pateients with Kostmann syndrome: severe congenital neutropenia. |
| 15033827 |
Expression of bcl(2) was present in only 5 cases or rectal cancer with the postchemotherapy changes being not significant. |
| 15061204 |
Patients with BCL2 overexpression showed significantly inferior disease free survival rate |
| 11864421 |
The over-expression of bcl-2 in the lens epithelium of fetus and children suggests that bcl-2 might be related to the development of cataract. |
| 11971816 |
IGFBP-3 inactivates Bcl-2 through serine phosphorylation. |
| 12209154 |
REVIEW: The Bcl2 family: regulators of the cellular life-or-death switch |
| 12749011 |
Bcl-2 should be considered as independent biologic prognostic parameter in diffuse large B-cell lymphoma, thereby aiding in the identification of patient risk groups. |
| 14555646 |
bcl-2 transcriptional regulation is mediated by the sonic hedgehog signaling pathway through gli-1 |
| 14647416 |
Human prolactin-G129R-induced breast cancer cell and/or mammary gland apoptosis which is mediated, at least in part, through the regulation of Bax and Bcl-2 gene expression. |
| 14647426 |
bcl-2 may inhibit cell death at multiple points downstream of p53 activation |
| 11158204 |
Review. Regulation of BCL2 phosphorylation and its role in leukemic cell apoptosis and drug resistance. |
| 11787859 |
Cells of JM1 human cell line treated with sanguinarine expressed BCL2 protein in apoptosis and cell death. |
| 12086670 |
Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability |
| 12172977 |
The lack of Bcl2 accompanied by p53 overexpression affects the distribution of cells among the cell cycle phases and modifies the sensitivity to cytotoxic drugs and the type of cell death. |
| 14554083 |
upregulation protects against apoptosis effected by live rabies virus vaccine strain in Jurkat T-cells and results in the establishment of long-term, persistently infected cultures that continue to produce rabies virus |
| 14964781 |
Levels of Bcl-2 are decreased in three important brain tissues, i.e. frontal, parietal, and cerebellar cortices of autistic subjects, alluding to impaired apoptotic mechanisms in autism. |
| 12101183 |
photoactivated hypericin does not cause Bcl-2 degradation but induces Bcl-2 phosphorylation in a dose- and time-dependent manner; Bcl-2 phosphorylation may be a signal to delay apoptosis in G(2)/M phase-arrested cells |
| 11914580 |
Bcl-2 upregulation by HIV-1 Tat during infection of primary human macrophages in culture. |
| 12197229 |
increased expression of bcl-2 protein plays an important role in acquiring tolerance for testosterone ablation in mouse mammary carcinoma cells |
| 12197771 |
Lipotropes regulate gene expression in the human breast cancer cell line, MCF-7 |
| 12890867 |
Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias. |
| 12939460 |
These data indicate that As(2)O(3) induces apoptosis in T cells by enhancing oxidative stress and that Bcl-2 appears to play a major role in As(2)O(3)-induced apoptosis. |
| 15889622 |
Bax but not Bcl-2 expression is increased after exposure to prostaglandin A2 and 2-methoxyestradiol in Hela cells |
| 16479062 |
The expression rate of bcl-2 was relatively high in small cell lung cancer without any prognostic significance. |
| 16538384 |
Data suggest that 2-methoxyestradiol 2 inhibits estradiol-stimulated proliferation and induces apoptosis in ovarian carcinoma cells, and that activation of p38 and phosphorylation of Bcl-2 plays a critical role in the mechanism. |
| 16550596 |
Expression of both bcl-2 and cyclooxygenase-2 were increased in non-dysplastic Barr |
| 16950491 |
Bcl-2 expression acts as a regulator of HSV-2 replication. |
| 16949642 |
The high expression of bcl-2 in Hodgkin and Reed-Sternberg cells in most classical Hodgkin's lymphomas (HLs)indicates that this protein may play predominant role in the regulation of apoptosis in classical HLs. |
| 16960146 |
BCL2-938AA genotype is associated with increased Bcl-2 expression and a novel unfavorable genetic marker in patients with B-CLL. |
| 17091766 |
The expression of p53, Bcl-2 and Bax was altered in lung cancer tissue compared to histologically normal bronchial epithelium. |
| 17200714 |
Activator BH3-only occupation of BCL2 may prime cancer cells for death, offering a potential explanation for the marked chemosensitivity of certain cancers. |
| 17384650 |
This study is the first to show a clear dissociation between changes in Bcl-2 expression (downregulation) and Bcl-XL, Mcl-1 expression (upregulation) during progression of melanoma. |
| 12440815 |
Bcl-2 expression, especially in preinvasive cervical lesions may play a role in the apoptotic process and be regarded as a marker for disease progression |
| 12133494 |
Association between Bcl-2 gene polymorphism with systemic lupus erythematosus(Bcl-2) |
| 12011972 |
Bcl-2 expression in lymphocytes infiltrating into the liver was investigated by immunohistochemistry |
