Saturday November 21 2009 | Biotechnology feed | All feeds

BioPortfolio Biotechnology Pharmaceutical Healthcare Medical Life Science Drug Discovery Disease

BCL2L1


Suggest Content
Advertise Here
Gene DB Home
Symbol:BCL2L1
Name(s):BCL2-like 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:BCL-XL/S, BCL2L, BCLX, Bcl-X, DKFZp781P2092, bcl-xL, bcl-xS
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18182854 The Bcl-X(L) chimeras that are targeted to the mitochondria and the wild type Bcl-X(L) provided same protection against cell death under several death inducing conditions.
12161031 Observational study of gene-disease association. (HuGE Navigator)
17942397 Shp2E76K induces cytokine-independent survival of TF-1 cells by a novel mechanism involving up-regulation of Bcl-XL through the Erk1/2 pathway.
17673921 results indicate an action of Bcl-X(L) modulating human neural stem cell differentiation
17873279 activation of HSF1 and stabilization of Bcl-X(L) mediate a protective response that may contribute significantly to the cellular biology of lipid peroxidation
17893147 a caspase-9 signaling cascade induces feedback disruption of the mitochondrion through cleavage of anti-apoptotic Bcl-2, Bcl-xL, and Mcl-1
17923691 The protein kinase C (PKC) inhibitor and apoptotic inducer staurosporine switches the production of Bcl-x towards the x(S) mRNA isoform in 293 cells.
17923112 low dose doxorubicin-induced cell death through mitotic catastrophe may provide an alternative therapeutic strategy for Bcl-xL-overexpressing hepatoma cells
17880809 We conclude that alteration in the expression of proapoptotic (Bax, Bak) and antiapoptotic (Bcl-2, Bcl-XL) proteins on surface of thyroid follicular cells may play a role in the pathogenesis of thyroid autoimmune disorders.
17657164 Bcl-X(L) conferred complete resistance to apoptosis induced by fas ligation in atherosclerotic carotid artery.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDAPAF1BCL2-like 1 isoform 1--Pubmed
HPRDApoptotic protease activating factorBCL2-like 1 isoform 1--Pubmed
HPRDapoptotic peptidase activating factor 1 isoform cBCLX--Pubmed
HPRDBCL2 antagonist of cell deathBCL2-like 1 isoform 1--Pubmed
BIND-BCL2-like 1 isoform 1Bcl-XL interacts with Bad. This interaction was modelled on a demonstrated interaction between Bcl-XL from an unspecified species and human Bad.-Pubmed
HPRDBCL2-antagonist of cell death proteinBCL2-like 1 isoform 1--Pubmed
HPRDBCL2-antagonist of cell death proteinBCL2-like 1 isoform 1--Pubmed
BINDBCL2-antagonist of cell death proteinBCL2-like 1 isoform 1Bad interacts with Bcl-xL.-Pubmed
BINDBCL2-antagonist of cell death proteinBCL2-like 1 isoform 1Bad interacts with Bcl-XL.-Pubmed
HPRDBAG 1BCL2-like 1 isoform 1--Pubmed

Recent Publications on BCL2L1:

Pubmed Logo
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1.
The proto-oncogene KRAS is mutated in a wide array of human cancers, most...
23rd October, 2009
[1] Department of Medical Oncology, [2] Broad Institute of Harvard and Nature. 2009 Oct 21.
DOI Direct Link
The liver's dance with death: two Bcl-2 guardian proteins from the abyss.
Mammalian females are endowed with a finite number of primordial follicles...
21st October, 2009
Hepatology. 2009 Oct;50(4):1009-13.
DOI Direct Link
Mcl-1 and Bcl-xL cooperatively maintain integrity of hepatocytes in developing and adult murine liver.
Anti-apoptotic members of the Bcl-2 family, including Bcl-2, Bcl-xL,...
21st October, 2009
Department of Gastroenterology and Hepatology, Osaka University Graduate Hepatology. 2009 Oct;50(4):1217-26.
DOI Direct Link
Pancreatic cancer cells resistance to gemcitabine: the role of MUC4 mucin.
BACKGROUND: A major obstacle to the successful management of pancreatic...
15th October, 2009
Department of Biochemistry and Molecular Biology, University of Nebraska Br J Cancer. 2009 Oct 6;101(7):1155-61. Epub 2009 Sep 8.
DOI Direct Link
Subfertility Caused by Altered Follicular Development and Oocyte Growth in Female Mice Lacking PKBalpha/Akt1.
Mammalian females are endowed with a finite number of primordial follicles...
2nd October, 2009
Biol Reprod. 2009 Sep 30.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7611839 Methods for diagnosing RCC and other solid tumors
6692916 Systems and methods for characterizing a biological condition or agent using precision gene expression profiles
6960439 Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
6964850 Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
7081340 Gene expression profiling in biopsied tumor tissues

View more patents.

BCL2L1 results (if any) from reagent suppliers

Google CSE Logo
BCL2L1 antibody (ab2568) | Abcam
12 Apr 2006 ... Rabbit polyclonal to BCL2L1. The protein encoded by this gene belongs to the Bcl2 protein family. Bcl2 family members form hetero or ...
http://www.abcam.com/bcl2l1-antibody-ab2568.html...

Thumbshot
BCL2L1 Antibody
Specific antibody for the gene product of BCL2L1, the protein BCL2-like protein 1. Validated for specificity by gene-silencing with siRNA followed by ...
http://www.piercenet.com/products/browse.cfm?fldID=25282527-...

Thumbshot
BCL2L1 Antibody (Center)
(LEFT)Western blot analysis of BCL2L1 antibody (Center) (Cat.#AP7958c) in Y79 cell line lysates (35ug/lane). BCL2L1(arrow) was detected using the purified ...
http://www.abgent.com/products/catalog_no/AP7958c_BCL2L1_Ant...

Thumbshot
BCL2L1 Antibody Apoptosis regulator bcl-xL
BCL2L1 antibody can be stored at 4C for short term (weeks) and -20C for long term.,
http://www.prosci-inc.com/shop/catalog1/BCL2L1-Antibody-p-16...

Thumbshot
Bcl2l1 antibody, Mouse Anti-Human Bcl-xL Antibody, Mouse ...
Buy quality mouse Bcl2l1 antibody (interacts with human), anti-Bcl2l1, Mouse Anti-Human Bcl-xL antibody, mouse monoclonal antibody, Mouse Anti-Human Bcl-xL
...
http://www.genwaybio.com/product_info.php?products_id=276240...

Thumbshot
BCL2L1 Antibody (N-term)
Formalin-fixed and paraffin-embedded human brain tissue reacted with BCL2L1 antibody (N-term) (Cat.# AP7958a), which was peroxidase-conjugated to the ...
http://www.abgent.com/products/catalog_no/AP7958a_BCL2L1_Ant...

Thumbshot
Antibodies to Bcl-2 Family Proteins
affinity isolated antibody, rat ... Bcl2l1(24888) mouse ... Bcl2l1(12048) human ... BCL2L1(598), mouse, rat, human, ARR, IHC (p), WB, pricing ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

Thumbshot

Search Bioportfolio and other Life Science Sites for BCL2L1, or search for BCL2L1 on BioPortfolio's antibody search engine.
This page has been viewed 568 times
Recent Search Terms used to find this page:
bcl2-l1 isoforms | Bcl-2-like protein 1 | Bcl-2 2009 | bcl2 like protein 1 | BCL2-like 1 and bcl xl | Bcl2 synonyms | Bcl2-like isoform | pubmed bcl2l1 | BCL2L1 Synonyms BCL2L BCLX | .


Resources from the NCBI used on this page, NCBI's standard disclaimer applies.

 

Nothing in this website should be used in place of personal medical advice from your own qualified medical practitioner.

All rights reserved. All other trademarks recognized.
Copyright 1997-2009 - BioPortfolio Limited.