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BCL2L2

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Symbol:	BCL2L2
Name(s):	BCL2-like 2
Type:	protein-coding
Organism:	Homo sapiens
Synonyms:	BCL-W, BCLW, KIAA0271
Links:	Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications
Publication Link	Summary of findings
17459056	overexpressed BCL2L2, through amplification or other mechanisms, promotes the growth of a non-smalll cell lung caner cell line.
12660157	structure of reveals a role for the C-terminal residues in modulating biological activity
12651847	although the cytosolic domain of BCL-w exhibits an overall structure similar to that of BCL-xL and BCL-2, the unique organization of its C-terminal helix may modulate BCL-w interactions with pro-apoptotic binding partners
15147516	Bcl-w may play an important protective role in neurons in the Alzheimer disease brain and this aspect could be therapeutically harnessed to afford neuroprotection
16475813	Peptide = to BH3 region of proapoptotic protein BID, bound in cleft of antiapoptotic protein BCL-w.Binding induced major conformational rearrangements in both peptide & protein components & led to displacement & unfolding of BCL-w C-terminal alpha-helix.

Interacting gene products
Interaction Type	Gene 1	Gene 2	Interaction description	Complex	Publication Link
HPRD	BCL2 antagonist of cell death	BCL2-like 2 protein	-	-	Pubmed
HPRD	BCL2-antagonist of cell death protein	BCLW	-	-	Pubmed
BIND	BCL2-antagonist of cell death protein	BCL2-like 2 protein	Bad interacts with Bcl-w.	-	Pubmed
HPRD	BCLW	Bcl2 modifying factor isoform bmf-1	-	-	Pubmed
HPRD	BCL2-like 2 protein	Bcl2 modifying factor	-	-	Pubmed
BIND	BCL2-like 2 protein	Bcl2 modifying factor isoform bmf-1	Bmf interacts with Bcl-w. This interaction was modelled on a demonstrated interaction between mouse Bmf and human Bcl-w.	-	Pubmed
BIND	BCL2-like 2 protein	BH3 interacting domain death agonist isoform 2	Bid interacts with Bcl-w.	-	Pubmed
BIND	BCL2-like 2 protein	BCL2-interacting killer	Bik interacts with Bcl-w.	-	Pubmed
BIND	BCL2-like 2 protein	harakiri	Hrk interacts with Bcl-w.	-	Pubmed
BIND	BCL2-like 2 protein	BCL2-like 11 isoform 6	Bim interacts with Bcl-w.	-	Pubmed

Recent Publications on BCL2L2:
Cloning and characterization of the 5'UTR of the rat anti-apoptotic Bcl-w gene. The anti-apoptotic Bcl-w regulator, which is expressed in the developing...	3rd November, 2009	Department of Anatomy and Regenerative Biology, George Washington	Biochem Biophys Res Commun. 2009 Nov 27;389(4):657-62. Epub 2009 Sep 17. DOI Direct Link
A putative role for human BFK in DNA damage-induced apoptosis. Human BFK (BCL-2 family kin) is a novel pro-apoptotic BCL-2 family member...	22nd October, 2009	Department of Molecular Biology and Genetics, Apoptosis and Cancer	Biotechnol J. 2009 Jul;4(7):1046-54. DOI Direct Link
MicroRNA 133B targets pro-survival molecules MCL-1 and BCL2L2 in lung cancer. Lung cancer is the most frequent cause of cancer-related death in this...	14th October, 2009	Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, DHLRI,	Biochem Biophys Res Commun. 2009 Oct 23;388(3):483-9. Epub 2009 Aug 3. DOI Direct Link
Cartilage polysaccharide induces apoptotic cell death of L1210 cells. We investigated the antitumor effect of a short-chain polysaccharide (PS)...	29th September, 2009	Key Laboratory of Food Nutrition and Safety, Ministry of Education,	Leuk Lymphoma. 2009 Jun;50(6):1017-29. DOI Direct Link
Folate supplementation limits the aggressiveness of glioma via the remethylation of DNA repeats element and genes governing apoptosis and proliferation. PURPOSE: We have investigated whether the folate supplementation could be...	4th August, 2009	Institut National de la Sante et de la Recherche Medicale U892, Centre de	Clin Cancer Res. 2009 May 15;15(10):3519-29. DOI Direct Link
→View more research publications.

Patents:
US Patent No.	Title
7601501	Controlling osteogenesis by inhibition of osteogenic suppressors
7341552	Gene sets for glioma classification
6706867	DNA array sequence selection
6673908	Tumor necrosis factor receptor 2

BCL2L2 results (if any) from reagent suppliers

Bcl2L2 proteins and peptides: Cell Biology > Apoptosis ... Bcl2L2 proteins and peptides. ... Image Abreview Publication. ab58944 · Bcl2L2 protein (His tag). SDS-PAGE, FuncS. Terms and conditions · Legal ... http://www.abcam.com/index.html?t=58624&pt=2&c=299&ei=&mu=ra...
Bcl-w Antibody (BH3 Domain Specific) 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the BCL2L2 gene (Lane 2) (Origene Technologies). ... http://www.abgent.com/products/catalog_no/AP1305a...
Bcl-w (G-21) Antibody sc-130701 Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, BCL2L2, 599, 14q11.2, Q92843 ... http://www.scbt.com/datasheet-130701-bcl-w-g-21-antibody.htm...
Antibodies to Bcl-2 Family Proteins purified immunoglobulin, mouse ... Bcl2l2(12050) human ... BCL2L2(599), human, mouse, WB, pricing. B9429, Monoclonal Anti-Bcl-xL antibody produced in mouse ... http://www.sigmaaldrich.com/etc/controller/controller-page.h...
Apoptosis: the Bcl2 family \| Abcam Bcl2 antibodies · Bcl-X (Bcl2L1) antibodies · Bcl-W (Bcl2L2) antibodies · Bfl1 ( Bcl2A1) antibodies · MCL1 antibodies. Bax-like multidomain (pro-apoptotic) ... http://www.abcam.com/index.html?pageconfig=resource&rid=1168...
Bcl-w (G-21) Antibody sc-130701 Species, 遺伝子名, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. ヒト, BCL2L2, 599, 14q11.2, Q92843 ... http://www.scbt.com/ja/datasheet-130701-bcl-w-g-21-antibody....
Cell Biology: primary antibodies, proteins, peptides, kits \| Abcam ... Bcl2A1 proteins and peptides (3) · Bcl2L2 antibodies (4) · Bcl2L2 proteins and peptides (1) · Bid antibodies (14) · Bid proteins and peptides (7) ... http://www.abcam.com/index.html?cl=246&pageconfig=productmap...

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BCL2L2

Gene Information from Publications

Interacting gene products

Recent Publications on BCL2L2:

Patents:

BCL2L2 results (if any) from reagent suppliers