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RHEB
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18324915 |
RHEB could be used cytopathologically to distinguish fibroadenoma from malignant breast carcinomas as a secondary diagnostic tool. |
| 17928295 |
Bnip3, a hypoxia-inducible Bcl-2 homology 3 domain-containing protein, directly binds Rheb and inhibits the mTOR pathway. |
| 17991864 |
findings suggest that FKBP38 is an endogenous inhibitor of mTOR, whose inhibitory activity is antagonized by Rheb in response to growth factor stimulation and nutrient availability |
| 17018601 |
The TSC/Rheb/mTOR pathway plays a critical role in the regulation of E(2)-induced proliferation. |
| 12869586 |
Rheb acts downstream of TSC1/TSC2 and upstream of mTOR to regulate cell growth |
| 15809346 |
results suggest that Rheb regulates endocytic trafficking pathway independent of the previously identified mTOR pathway. |
| 16098514 |
Data show that Rheb like-1 protein (RhebL1) rescues mTOR signaling during nutrient withdrawal, and identify critical residues in Rheb and RhebL1 which are required for their efficient activation of mTOR signaling. |
| 15150271 |
Rheb has a role in regulation of B-Raf kinase activity along with tuberin but without involvement of mTOR |
| 15340059 |
To investigate the function of TSC2 and Rheb in mTOR signaling, we analyzed the TSC2-stimulated Rheb GTPase activity. |
| 12842888 |
Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner | →View more information from publications. |
Recent Publications on RHEB: |  |
Functional interaction of mammalian target of rapamycin complexes in regulating mammalian cell size and cell cycle.
Dysregulation of the mammalian target of rapamycin (mTOR) kinase pathway... | 3rd November, 2009
| Medical Genetics, Medical University of Vienna, 1090 Vienna, Austria.
| Hum Mol Genet. 2009 Sep 1;18(17):3298-310. Epub 2009 Jun 8.
DOI Direct Link |
Regulation of mTOR complex 1 (mTORC1) by raptor S863 and multi-site phosphorylation.
The rapamycin-sensitive mTOR complex 1 (mTORC1) promotes protein... | 30th October, 2009
| University of Michigan Medical School, United States;
| J Biol Chem. 2009 Oct 28.
DOI Direct Link |
A second-site noncomplementation screen for modifiers of Rho1 signaling during imaginal disc morphogenesis in Drosophila.
BACKGROUND: Rho1 is a small GTPase of the Ras superfamily that serves as... | 29th October, 2009
| Department of Molecular Biosciences, University of Kansas, Lawrence,
| PLoS One. 2009 Oct 23;4(10):e7574.
DOI Direct Link |
Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling.
The Rheb1 and Rheb2 small GTPases and their effector mTOR are aberrantly... | 20th October, 2009
| Curriculum in Genetics and Molecular Biology, University of North Carolina
| Oncogene. 2009 Oct 19.
DOI Direct Link |
Molecular basis of the acceleration of the GDP-GTP exchange of human ras homolog enriched in brain by human translationally controlled tumor protein.
Ras homolog enriched in brain (Rheb), a small GTPase, positively regulates... | 20th October, 2009
| State Key Laboratory of Molecular Biology and Research Center for
| J Biol Chem. 2009 Aug 28;284(35):23754-64. Epub 2009 Jul 1.
DOI Direct Link |
→View more research publications. |
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