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BCL3


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Gene DB Home
Symbol:BCL3
Name(s):B-cell CLL/lymphoma 3
Type:protein-coding
Organism:Homo sapiens
Synonyms:BCL4, D19S37
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
16311697 Observational study of gene-disease association. (HuGE Navigator)
17272867 Observational study of gene-disease association. (HuGE Navigator)
1923524 Characterization of the mouse BCL3 ortholog and comparison to the human gene.
18025803 demonstrated that HCCs almost universally overexpress Bcl-3 and preferentially express nuclear p52 and p50, with little evidence of p65 activation.
17881446 induction of p50/p50/Bcl-3 complexes by latent membrane protein 1 (LMP1) C-terminal activating region 1 mediates LMP1-induced epidermal growth factor receptor upregulation
17644518 BCL3 functions as a repressor of HTLV-1 LTR-mediated transcription through interactions with TORC3
17495977 study indicates that BCL3 translocations are not restricted to B-cell chronic lymphocytic leukemia but present in a heterogeneous group of B-cell malignancies
12456498 High-level expression of BCL3 differentiates t(2;5)(p23;q35)-positive anaplastic large cell lymphoma from Hodgkin disease.
15634875 Supported by IL-12 signals, Bcl-3 enhances survival and clonal expansion of transgenic OT-1 CD8 T cells.
16108830 (p52)2/Bcl-3P ternary complex, which is specifically induced in CD30-stimulated anaplasstic larage cell lymphoma, can modulate expression of apoptosis-related genes regulated by NF-kappaB.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDBRCA1 associated RING domain 1B-cell CLL/lymphoma 3--Pubmed
HPRDBRCA1 associated RING domain 1B-cell CLL/lymphoma 3--Pubmed
BINDB-cell CLL/lymphoma 3-HTATIP (Tip60) interacts with BCL3.-Pubmed
BINDB-cell CLL/lymphoma 3Homo sapiens chromosome 11, reference assembly.BCL3 interacts with the CD82 (KAI1) promoter.-Pubmed
BINDB-cell CLL/lymphoma 3catenin, beta 1, 88kDaCTNNB1 (beta-catenin) interacts with BCL3.-Pubmed
HPRDB-cell CLL/lymphoma 3protein-tyrosine kinase fyn isoform a--Pubmed
HPRDB-cell CLL/lymphoma 3protein-tyrosine kinase fyn isoform a--Pubmed
BINDB-cell CLL/lymphoma 3glycogen synthase kinase 3 betaGSK3-beta interacts with and phosphorylates BCL-3.-Pubmed
HPRDB-cell CLL/lymphoma 3jun oncogene--Pubmed
HPRDB-cell CLL/lymphoma 3jun oncogene--Pubmed

Recent Publications on BCL3:

Pubmed Logo
Bcl3 interacts cooperatively with peroxisome proliferator-activated receptor gamma (PPARgamma) coactivator 1alpha to coactivate nuclear receptors estrogen-related receptor alpha and PPARalpha.
Estrogen-related receptors (ERRs) play critical roles in regulation of...
26th September, 2009
Burnham Institute for Medical Research, 6400 Sanger Road, Orlando, FL Mol Cell Biol. 2009 Aug;29(15):4091-102. Epub 2009 May 18.
DOI Direct Link
Xp11.2 translocation renal cell carcinoma occurring during pregnancy with a novel translocation involving chromosome 19: a case report with review of the literature.
ABSTRACT: The recently recognized renal cell carcinomas (RCCs) associated...
20th May, 2009
Department of Pathology, Presbyterian-Shadyside Hospital, University of Diagn Pathol. 2009 May 18;4:15.
DOI Direct Link
High expression of BCL3 in human myeloma cells is associated with increased proliferation and inferior prognosis.
BACKGROUND: BCL3 is a putative oncogene encoding for a protein belonging...
19th May, 2009
Department of Cancer Research and Molecular Medicine, Norwegian University Eur J Haematol. 2009 May;82(5):354-63. Epub 2009 Jan 13.
DOI Direct Link
Differential parental transmission of markers in BCL3 among Korean cleft case-parent trios.
OBJECTIVES: Isolated cleft lip with or without cleft palate (CL/P) is...
4th April, 2009
Yonsei University School of Medicine, Seoul, Korea. J Prev Med Public Health. 2009 Jan;42(1):1-4.
DOI Direct Link
The proto-oncogene Bcl3, induced by Tax, represses Tax-mediated transcription via p300 displacement from the human T-cell leukemia virus type 1 promoter.
The etiology of human T-cell leukemia virus type 1 (HTLV-1)-induced adult...
17th December, 2008
Department of Biochemistry and Molecular Biology, Campus Box 1870, J Virol. 2008 Dec;82(23):11939-47. Epub 2008 Sep 24.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Effect of Pimecrolimus Cream on Cathelicidin Levels in Subjects With Eczema

Patents:

Patents logo
US Patent No.Title
7300162 Projection display
7414296 Method of manufacturing a metal-insulator-metal capacitor
7415358 Molecular toxicology modeling
7420055 Aryl sulfonamides
7420209 Semiconductor device

View more patents.

BCL3 results (if any) from reagent suppliers

Google CSE Logo
Bcl3 antibody [Ham150-3.5] (ab15046) | Abcam
Hamster monoclonal [Ham150-3.5] to Bcl3. This gene is a protooncogene candidate. It is identified by its translocation into the immunoglobulin alpha locus ...
http://www.abcam.com/Bcl3-antibody-Ham150-3-5-ab15046.html...

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Boron trichloride (BCl3) — Boron(III) chloride
SAFC Hitech can supply Boron Trichloride (BCl3) in a range of purities and containers, to customers throughout Europe, the US and Asia.
http://www.sigmaaldrich.com/safc-hitech/en-us/home/overview/...

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Bcl3 antibodies: Immunology > Adaptive Immunity > B Cells > Non-CD ...
Bcl3 antibodies. ... Bcl3 antibody. IP, WB, IHC-Fr. Rabbit polyclonal. Reacts with: Hu, Ms, Rat. ab49470 · Bcl3 antibody [1E8]. IHC-P, IHC-Fr ...
http://www.abcam.com/index.html?t=85588&pt=1&c=506&ei=&mu=ra...

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Order or Inquire about Boron trichloride, BCl3
Order Boron trichloride (BCl3)from SAFC Hitech in a range of purities and containers, to customers throughout Europe, the US and Asia.
http://www.sigmaaldrich.com/safc-hitech/en-us/home/overview/...

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SUPELCO
More stable than BF3 -methanol at room temperature (BCl3 is not as volatile as BF3). ... One of the main advantages of BCl3 over certain fluorine-containing
...
https://www.sigmaaldrich.com/etc/medialib/docs/Aldrich/Gener...

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p-Bcl-3 (Ser 394/398) Antibody sc-33883
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, BCL3, 602, 19q13.31, NM_005178 ...
http://www.scbt.com/datasheet-33883-p-bcl-3-ser-394-398-r-an...

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SUPELCO
acid catalyst (BCl3). In the reaction, the analyte and alcohol molecules ... One of the main advantages of BCl3 over certain fluorine-containing ...
https://www.sigmaaldrich.com/etc/medialib/docs/Aldrich/Gener...

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