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BCR
| Symbol: | BCR | | Name(s): | breakpoint cluster region | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | ALL, BCR1, CML, D22S11, D22S662, FLJ16453, PHL | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18070886 |
Bcr GTPase-activating domain activity is regulated through direct protein/protein interaction with the Rho guanine nucleotide dissociation inhibitor |
| 15248918 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15866548 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15968309 |
Observational study of genetic testing. (HuGE Navigator) |
| 17822820 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 18082628 |
These results demonstrate that allele-specific changes in gene expression, with selective, progressive silencing of the wild-type ABL1 allele in favor of the oncogenic BCR-ABL1 allele occur in CML patients with therapy-resistant disease. |
| 17768128 |
A novel e8/a4 BCR/ABL fusion transcript is associated with a transformed Sezary syndrome |
| 17939855 |
CML staining in cortical neurons and cerebral vessels is related to the severity of cognitive impairment in people with cerebrovascular disease and only minimal Alzheimer pathology. |
| 17682125 |
A role for LMP2A as an indispensable BCR mimic in certain B cells from which human B-cell tumors such as Hodgkin lymphoma originate. |
| 17638851 |
Strategies targeting signals in the marrow microenvironment that amplify the Bcr-abl/VE-cadherin/beta-catenin axis may have utility in sensitizing drug-resistant leukemic stem cells. | →View more information from publications. |
Recent Publications on BCR: |  |
Heavy metal bioavailability and bioaccessibility in soil.
This chapter considers the use of a variety of approaches to assess either... | 3rd November, 2009
| Biomolecular and Biomedical Research Centre, School of Applied Sciences,
| Methods Mol Biol. 2010;599:15-36.
DOI Direct Link |
Novel pathway in Bcr-Abl signal transduction involves Akt-independent, PLC-gamma1-driven activation of mTOR/p70S6-kinase pathway.
In chronic myeloid leukemia, activation of the phosphoinositide 3-kinase... | 3rd November, 2009
| [1] Department of Medicine (Cancer Research), West German Cancer Center,
| Oncogene. 2009 Nov 2.
DOI Direct Link |
ABC transporter A3 facilitates lysosomal sequestration of imatinib and modulates susceptibility of chronic myeloid leukemia cell lines to this drug.
Background Inhibition of BCR-ABL tyrosine kinase activity has evolved as a... | 3rd November, 2009
| Department Hematology and Oncology, Georg-August-University, Goettingen
| Haematologica. 2009 Nov;94(11):1528-36.
DOI Direct Link |
Correlation of JAK2 V617F mutant allele quantitation with clinical presentation and type of chronic myeloproliferative neoplasm.
Activating JAK2 V617F mutation is present in many patients with chronic... | 3rd November, 2009
| Clinical Pathology Department, William Beaumont Hospital, Royal Oak,
| Ann Clin Lab Sci. 2009 Fall;39(4):345-50.
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Selecting optimal second-line tyrosine kinase inhibitor therapy for chronic myeloid leukemia patients after imatinib failure - does the BCR-ABL mutation status really matter?
Pre-clinical studies of BCR-ABL mutation sensitivity to nilotinib or... | 3rd November, 2009
| Centre for Cancer Biology, Departments of Molecular Pathology and
| Blood. 2009 Oct 30.
DOI Direct Link |
→View more research publications. |
Press Releases on BCR:
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| Christiana Care First Community Hospital to Submit Samples to Cancer Genome Atlas Project |
12th November, 2009 |
Christiana Care Health System |
WILMINGTON, Del., Nov. 12 /PRNewswire-USNewswire/ -- Christiana Care Health System's Helen F. Graham Cancer Center became the first community hospital in the nation to submit
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| China Medical Technologies Receives SFDA Approval for its Leukemia BCR/ABL Fusion Gene Detection FISH Probe |
9th November, 2009 |
China Medical Technologies, Inc. |
BEIJING, Nov. 9 /PRNewswire-Asia-FirstCall/ -- China Medical Technologies,
Inc. (the "Company") (Nasdaq: CMED), a leading China-based medical device
company that develops,
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| Reportlinker Adds Who's Doing What in Molecular Diagnostics? - Kalorama / Emmes Survey of US Laboratories Report |
24th September, 2009 |
Reportlinker |
-- Communicable Diseases - CMV (Cytomegalovirus), EBV (Epstein-Barr Virus),
Group B Strep, Enterovirus
What Labs Do Now, What They are Planning in the Future
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| Cepheid Announces European Release of Improved Test for BCR-ABL Chromosomal Translocation Associated With Chronic Myelogenous Leukemia (CML) |
17th June, 2009 |
Cepheid |
Oncology Test Further Highlights Broad Market Applicability of GeneXpert System
SUNNYVALE, Calif., June 17 /PRNewswire-FirstCall/ -- Cepheid
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| Quest Diagnostics to Present Genomic Studies Related to New Testing Techniques for Leukemia and Prostate Cancer at 2009 ASCO Meeting |
28th May, 2009 |
Quest Diagnostics |
MADISON, N.J., May 28 /PRNewswire-FirstCall/ -- Quest Diagnostics scientists will present results of three studies revealing the effect of genomic abnormalities on the diagnosis and treatment of
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BCR results (if any) from reagent suppliers | 
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