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RPS19


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Gene DB Home
Symbol:RPS19
Name(s):ribosomal protein S19
Type:protein-coding
Organism:Homo sapiens
Synonyms:DBA
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17962699 RPS19 deficiency causes apoptosis and accelerated loss of erythroid progenitors in RPS19-deficient Diamond-Blackfan anemia.
17107358 Observational study of genotype prevalence. (HuGE Navigator)
17178250 RPS19 is a ribosomal protein linked to Diamond-Blackfan anemia
17517689 Diamond-Blackfan anemia missense mutations affect the assembly of ribosomal protein S19 into the ribosome
15626736 RPS19 silencing decreases the proliferative capacity of hematopoietic progenitors and leads to a defect in erythroid development
16266891 The PIM-1/RPS19 interaction was demonstrated both in vitro and in living cells and led to phosphorylation of RPS19 in an in vitro kinase assay.
11942409 Study suggests that RPS19 overexpression might be a universal signal in rapid cell growth tissues.
17199736 The RP S19 dimer inhibits C5a-induced neutrophil migration and promotes apoptosis of neutrophils via the C5a receptor.
17082006 RPS19 mutations affecting RPS19 conserved arginines R56Q and R62Q could significantly inhibit the rate of protein synthesis, indicating the importance of RPS19 in translation.
12651630 results indicated that the conversion of the RP S19 dimer from agonist to antagonist of C5a receptor is attributed to the IAGQVAAANKK moiety between Ile134 and Lys144

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDComplement component 5 receptor 1ribosomal protein S19--Pubmed
HPRDcomplement component 5 receptor 1Ribosomal protein S19--Pubmed
HPRDfibroblast growth factor 2ribosomal protein S19--Pubmed
HPRDfibroblast growth factor 2ribosomal protein S19--Pubmed

Recent Publications on RPS19:

Pubmed Logo
Fibroblasts from patients with Diamond-Blackfan anaemia show abnormal expression of genes involved in protein synthesis, amino acid metabolism and cancer.
BACKGROUND: Diamond-Blackfan anaemia (DBA) is a rare inherited red cell...
31st October, 2009
Department of Medical Sciences and Interdisciplinary Research Center of BMC Genomics. 2009 Sep 18;10:442.
DOI Direct Link
Diamond-Blackfan anemia: genotype-phenotype correlation in Italian patients with RPL5 and RPL11 mutations.
Background Diamond-Blackfan anemia (DBA) is a rare, pure red blood cell...
24th September, 2009
Pediatric Department, University of Torino, Italy. Haematologica. 2009 Sep 22.
DOI Direct Link
Ribosomal protein S19 and S24 insufficiency cause distinct cell cycle defects in Diamond-Blackfan anemia.
Diamond-Blackfan anemia (DBA) is a severe congenital anemia characterized...
20th August, 2009
Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala Biochim Biophys Acta. 2009 Oct;1792(10):1036-42. Epub 2009 Aug 16.
DOI Direct Link
A GeNorm algorithm-based selection of reference genes for quantitative real-time PCR in skin biopsies of healthy dogs and dogs with atopic dermatitis.
Quantitative real time PCR (Q-PCR) is the method of choice to study mRNA...
31st July, 2009
Department of Clinical Sciences of Companion Animals, Faculty of Vet Immunol Immunopathol. 2009 May 15;129(1-2):115-8. Epub 2008 Dec 6.
DOI Direct Link
Targeted resequencing and analysis of the Diamond-Blackfan anemia disease locus RPS19.
BACKGROUND: The Ribosomal protein S19 gene locus (RPS19) has been linked...
10th July, 2009
The Linnaeus Centre for Bioinformatics Uppsala University/Swedish PLoS One. 2009 Jul 9;4(7):e6172.
DOI Direct Link

View more research publications.

Press Releases on RPS19:

BioPortfolio Logo
ASH Announces 2009 Merit Award Winners 25th November, 2009 American Society of Hematology

WASHINGTON, Nov. 25 /PRNewswire-USNewswire/ -- The American Society of Hematology (ASH) is pleased to recognize the following abstract presenters with the highest scoring abstracts in

Patents:

Patents logo
US Patent No.Title
7608395 Systemic lupus erythematosus diagnostic assay
6506581 Nucleotide sequence of the Haemophilus influenzae Rd genome, fragments thereof, and uses thereof
6528289 Nucleotide sequence of the Haemophilus influenzae Rd genome, fragments thereof, and uses thereof
6537773 Nucleotide sequence of the mycoplasma genitalium genome, fragments thereof, and uses thereof
6706867 DNA array sequence selection

View more patents.

RPS19 results (if any) from reagent suppliers

Google CSE Logo
RPS19 antibody (ab40833) | Abcam
Goat polyclonal to RPS19. RPS19 belongs to the ribosomal protein S19e family. Defects in this gene are a primary cause of Diamond-Blackfan anemia (DBA).
http://www.abcam.com/RPS19-antibody-ab40833.html...

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RPS19 monoclonal antibody (M01)
RPS19 (AAH00023, 1 a.a. ~ 146 a.a) full length recombinant protein with GST tag. ... RPS19 monoclonal antibody (M01), clone 3C6 Western Blot analysis of ...
http://www.abgent.com/products/catalog_no/AT3713a_RPS19_mono...

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Cayman Chemical | AROS Polyclonal Antibody (aa 1-50) | Description
... with an unknown function, interacts with extraribosomal protein RPS19, playing a role in the signaling pathways that regulate rRNA transcription. ...
http://www.caymanchem.com/app/template/Product.vm/catalog/13...

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Ribosomal Protein S19 (WW-4) Antibody sc-100836
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, RPS19, 6223, 19q13.2, NM_001022 ...
http://www.scbt.com/datasheet-100836-ribosomal-protein-s19-w...

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3C-3E
Monoclonal Anti-RPS19 antibody produced in mouse clone 3C6, purified immunoglobulin, buffered aqueous solution, 3C6 (monoclonal) ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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Ribosomal Protein S19 (N-16) Antibody sc-49095
Humano, RPS19, 6223, 19q13.2, NM_001022 · P39019 · 603474. Ratón, Rps19, 20085, 7 A3, Q9CZX8, No Aplicable. Información sobre pedidos ...
http://www.scbt.com/es/datasheet-49095-ribosomal-protein-s19...

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FLAG Literature
Deficient RPS19 protein production induces cell cycle arrest in erythroid progenitor cells, Kuramitsu, M., et al. British Journal of Haematology, 2008.
...
http://www.sigmaaldrich.com/life-science/proteomics/recombin...

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