Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17497677 |
Pathways of signaling by S100A4, by its interaction with and sequestration of p53, and by Notch also seem differentially operational in the induction of apoptosis |
| 18154362 |
Localized activation of S100A4 at the cell periphery was observed in fibroblasts during random migration and following stimulation with lysophosphatidic acid, a known activator of cell motility and proliferation. |
| 17673926 |
Hypomethylation is an important mechanism of regulating the expression of the S100A4 gene in endometrial carcinomas. |
| 17565747 |
Results show that S100A4 is expressed preferentially by various cell types present in the tumor microenvironment (macrophages, fibroblasts, activated lymphocytes), rather than by the tumor cells themselves. |
| 17550972 |
Results suggest that CTGF plays a crucial role in migratory/invasive processes in human breast cancer by a mechanism involving activation of the integrin-alphavbeta3-ERK1/2-S100A4 pathway. |
| 16243835 |
S100A4 is a mediator of metastasis [review] |
| 14640694 |
MTS1 regulates nonmuscle myosin IIA assembly by monomer sequestration and is able to regulate cell shape and motility through the modulation of myosin-IIA function. |
| 17504119 |
Review of implications of S11A4 involvement with and binding to its targets sheds additional light on the role of S100A4 in the control of tumor cell motility and migration. |
| 12645008 |
S100A4 showed the weakest expression of 3 S100 proteins (including S100A5 and S100A13) in the cells and fibers of the hippocampus and the temporal cortex at all stages examined (from 12 to 33 weeks of gestation). |
| 16265347 |
overexpression of S100A4 is associated with thyroid tumour invasion and metastasis and it may be a potential target for therapeutic intervention |
| 16571622 |
S100A4 is expressed in leiomyomas and myometrium with relative expression level inversely correlating with TGF-beta. |
| 15334597 |
Mts1 acts as a neuroprotectant in primary cerebellar, dopaminergic, and hippocampal neurons induced to undergo cell death. |
| 11875708 |
The level of S100A4 mRNA is higher in carcinomas compared to normal specimens. |
| 16984379 |
The nuclear expression of S100A4 is involved in the aggressive behavior of ovarian carcinoma and S100A4 is an autocrine/paracrine factor that plays an important role in the aggressiveness of ovarian carcinoma cells. |
| 11994292 |
the functional role of S100A4 in regulating endothelial cell growth and tumor metastasis involves interaction with the N-terminal half of Methionine Aminopeptidase 2. |
| 15788416 |
S100A4 protein alone or in a complex with annexin II accelerated tissue plasminogen activator-mediated plasminogen activation in solution and on the endothelial cell surface |
| 12517790 |
S100A4 is a direct target of ERBB2 signaling in medulloblastoma cells |
| 12239456 |
observed differential expression of S100A6 and S100A4 suggests that S100A6, rather than S100A4, is associated with human colorectal adenocarcinoma tumorigenesis and invasion/metastasis |
| 12532418 |
Expression of mts1 mRNA was affected by E-cadherin transfection. Loss of E-cadherin expression followed by mts1 expression may be important for increasing cell proliferation, motility & invasion activity in the progression of gall bladder cancer. |
| 12756252 |
S100A4 localizes to the leading edge in a calcium-independent manner |
| 15713996 |
These findings suggest that (1) S100A4 plays a constitutive role in papillary carcinoma and (2) S100A4 may be a useful marker for early the detection of this carcinoma |
| 14713104 |
one of the mechanisms by which S100A4 may exert its effect on metastasis of some tumors is by regulating the MMP-2 activity. |
| 12379109 |
Each subunit of S100A4 has two EF-hand Ca2+-binding domains: a pseudo-EF-hand (or S100-hand) formed by helices 1 and 2 that adopts a conformation similar to other members of the S100 family, and a typical EF-hand. |
| 15781852 |
S100A4 regulates the oligomerization of p53 tumor suppressor by binding to its tetramerization domain. |
| 15956747 |
downregulation of mRNA and protein of the calcium binding protein S100A4 (metastasin) in MDA-MB-231/pIRES-EGFP-H2 transfectants |
| 16554030 |
These data suggest that S100A4, like SPARC, plays a supportive role in early in vitro cardiomyogenesis. |
| 16685438 |
high S100A4 expression is related to a poor prognosis through hematogenous metastasis in pulmonary adenocarcinoma. |
| 17200116 |
Increased expression of S100A4 was observed in the medulla and papilla, but not the cortex of a human kidney in response to hypertonic stress |
| 15852272 |
S100A4 may exert its effect on invasion and metastasis of neuroblastoma cells by stimulating the motility of tumor cells as well as influencing the expression of MMP-2 |
| 16990429 |
These data demonstrate that the S100A4 gene controls the invasive potential of human CaP cells through regulation of MMP-9 and that this association may contribute to metastasis of CaP cells. |
| 17051636 |
All the data in the present study suggested that S100A4 might contribute to HCC invasion and metastasis through two paths of matrix metalloproteinase (MMP9) secretion regulation and strengthened motility and invasion properties. |
| 17223348 |
high-grade glioblastomas express higher amount of S100A4/Mts1 than low-grade astrocytic tumors |
| 17276942 |
Expression of S100A4 protein was observed in 8 invasive carcinomas (80%), 5 high-grade dysphasia/carcinoma in situ cases (83%), and 0 low-grade dysplasia. |
| 12445462 |
S100A4 stimulates the migration rate of astrocytic tumor cells by modifying the organization of their actin cytoskeleton. |
| 15579771 |
S100A4 is involved in tumor progression and metastasis. It may be a potential target for therapeutic intervention. |
| 16367903 |
Involvement of S100A2 and S100A4 in the progression of lung adenocarcinomas provides a list of targets regulated by S100A2 and S100A4. |
| 12168821 |
Mutations of the cell cycle arrest gene p21WAF1, but not the metastasis-inducing gene S100A4, are frequent in oral squamous cell carcinomas from Sudanese toombak dippers and non-snuff-dippers from the Sudan, Scandinavia, USA and UK. |
| 11752788 |
crystallization and crystallographic analysis of structure |
| 16097057 |
Overexpression of S100A4 may be closely related with the aggressiveness of colorectal carcinoma. |
| 16489073 |
Resaults suggest that in human breast cancer, S100A4 exerts some of its effects through angiogenesis. |
| 16865243 |
S100A4 overexpression combined with reduced E-cadherin expression is associated with tumor progression and metastasis in pancreatic cancer |
| 16948116 |
Since both S100A4 and RAGE are up-regulated in osteoarthritis cartilage, this signaling pathway could contribute to cartilage degradation in this disease. |
| 17638890 |
S100A4 has a role in suppression of BNIP3 expression, chemoresistance, and inhibition of apoptosis in pancreatic cancer |
| 11786397 |
Overexpression of S100A4 in pancreatic ductal adenocarcinomas is associated with poor differentiation and DNA hypomethylation. |
| 12439718 |
association seen between S100A4 expression and aggressive breast tumor phenotype |
| 17032501 |
results demonstrate frequent cytosolic overexpression of S100A2 and S100A4 in Barrett's adenocarcinoma |
| 17219414 |
S100A4 protein is not expressed in benign or malignant prostatic epithelium nor in LNCaP and Du145 cells. |
| 17328050 |
Overexpression of S100A4 in rheumatoid arthritis synovial tissue can influence p53 function and modulate the expression of several genes that are potentially implicated in the disease process. |
