Sunday November 22 2009 | Biotechnology feed | All feeds

BioPortfolio Biotechnology Pharmaceutical Healthcare Medical Life Science Drug Discovery Disease

S100A6


Suggest Content
Advertise Here
Gene DB Home
Symbol:S100A6
Name(s):S100 calcium binding protein A6
Type:protein-coding
Organism:Homo sapiens
Synonyms:2A9, 5B10, CABP, CACY, PRA
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17726019 S100A6 modulates cell survival by interacting with distinct RAGE immunglobulin domains.
17495951 Cell-specific S100A6 expression is under control of epigenetic mechanisms in skin epithelial and neoplastic cells.
16157226 while S100A6 is commonly overexpressed in human osteosarcoma, loss of its expression correlates with a metastatic phenotype
12746458 Sgt1 binds to S100A6 in a calcium-regulated manner
12859951 These results suggest that NF-kappaB transcription factor contributes to the activation of S100A6 gene expression in response to tumor necrosis factor alpha in HepG2 cells.
15878395 Agents evoking oxidative stress activate calcyclin gene via the antioxidant response element in its promoter
17466273 This suggests that the interaction of Sgt1 with Hsp70 and Hsp90 is regulated by S100A6 in a Ca(2+)-dependent manner.
12239456 observed differential expression of S100A6 and S100A4 suggests that S100A6, rather than S100A4, is associated with human colorectal adenocarcinoma tumorigenesis and invasion/metastasis
11925593 findings suggest that up-regulation of FRalpha gene and calcyclin gene expressions induced by Allitridi may play an important role in human gastric cancer cell differentiation
11937060 Results are consistent with S100A6, and most likely other S100 proteins, functioning as Ca(2+) sensors in a way analogous to the prototypical sensors calmodulin and troponin C.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDAnnexin IIS100A6 protein--Pubmed
HPRDannexin A2 isoform 2Calcyclin--Pubmed
HPRDAnnexin A11S100A6 protein--Pubmed
HPRDannexin A11Calcyclin--Pubmed
HPRDGlyceraldehyde 3 phosphate dehydrogenaseS100A6 protein--Pubmed
HPRDglyceraldehyde-3-phosphate dehydrogenaseCalcyclin--Pubmed
HPRDCalcyclincalcyclin binding protein isoform 1--Pubmed
HPRDS100A6 proteinSiah1 interacting protein--Pubmed
HPRDS100A6 proteinS100A6 protein--Pubmed
HPRDS100A6 proteinS100 calcium-binding protein, beta--Pubmed

Recent Publications on S100A6:

Pubmed Logo
Increased cytoplasmic S100A6 expression is associated with pulmonary adenocarcinoma progression.
S100A6 is a calcium-binding protein implicated in many cellular processes...
30th October, 2009
Department of Pathology, Institute of Basic Medical Sciences, Graduate Pathol Int. 2009 Sep;59(9):623-30.
DOI Direct Link
iTRAQ-coupled 2-D LC-MS/MS analysis of protein profile associated with HBV-modulated DNA methylation.
The development of hepatocellular carcinoma (HCC) is believed to be...
29th October, 2009
Nanyang Technological University, Singapore. Proteomics. 2009 Aug;9(15):3856-68.
DOI Direct Link
Annexin I and annexin II N-terminal peptides binding to S100 protein family members: specificity and thermodynamic characterization.
The S100 proteins make up a family of dimeric calcium binding proteins...
23rd October, 2009
Department of Biology, Rensselaer Polytechnic Institute, Troy, New York Biochemistry. 2009 Mar 31;48(12):2788-98.
DOI Direct Link
Proteomic profiling in distinct cellular compartments of tumor cells reveals p53-dependent upregulation of S100A6 upon induction of telomere dysfunction.
Telomere dysfunction is evoking a DNA damage response which leads to...
17th October, 2009
University Medical Center Freiburg, Dept. Hematology/Oncology, Freiburg, Proteomics. 2009 Oct 15.
DOI Direct Link
S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility.
BACKGROUND: High levels of S100A6 have been associated with poor outcome...
15th October, 2009
Division of Surgery and Oncology, University of Liverpool, Liverpool, UK. Br J Cancer. 2009 Oct 6;101(7):1145-54. Epub 2009 Sep 1.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7608395 Systemic lupus erythematosus diagnostic assay
7235358 Methods and compositions for diagnosing and monitoring transplant rejection
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
7026121 Methods and compositions for diagnosing and monitoring transplant rejection
7005499 Wnt-regulated cytokine-like polypeptide and nucleic acids encoding same

View more patents.

S100A6 results (if any) from reagent suppliers

Google CSE Logo
S100A6 monoclonal antibody (M16)
S100A6 (NP_055439, 18 a.a. ~ 91 a.a) partial recombinant protein with GST tag. ... Western Blot analysis of S100A6 expression in transfected 293T cell line ...
http://www.abgent.com/products/catalog_no/AT3760a_S100A6_mon...

Thumbshot
S100A6 - R&D Systems
Mouse S100A6 (also prolactin receptor-associated protein and calcyclin) is a 10 kDa member of the S100 family of calcium-binding proteins. ...
http://www.rndsystems.com/molecule_detail.aspx?m=3759...

Thumbshot
Calcyclin (E-20) Antibody sc-16137
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIMâ„¢ Number. Human, S100A6, 6277, 1q21.3, NM_014624 ...
http://www.scbt.com/datasheet-16137-calcyclin-e-20-antibody....

Thumbshot
C7479 Anti-Calretinin antibody produced in rabbit affinity ...
... S-100b, S100A2 (S100L) and S100A6 (calcyclin). This sequence is identical in human and mouse calretinin and highly conserved in chicken calretinin. ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...

Thumbshot
galectin-1 (H-45) Antibody sc-28248
Induction of S100A4, S100A6, and galectin-1 during the lineage commitment of CD4 +CD8+ thymocyte cell line is suppressed by 2,3,7 ...
http://www.scbt.com/datasheet-28248-galectin-1-h-45-antibody...

Thumbshot
C2724 Anti-Calbindin-D-28K (EG-20) antibody produced in rabbit ...
... parvalbumin, S-100a, S-100b, S100A2 (S100L), and S100A6 (calcyclin). This sequence is highly conserved across species, e.g., in the corresponding human,
...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...

Thumbshot
S100A4 antibody (ab27957) | Abcam
Ab27957 does not cross-react with S100A1, S100A2, S100A6 or S100B. Tested applications (see key). ICC/IF, IHC-Fr, IHC-P, WB ...
http://www.abcam.com/S100A4-antibody-ab27957.html...

Thumbshot

Search Bioportfolio and other Life Science Sites for S100A6, or search for S100A6 on BioPortfolio's antibody search engine.
This page has been viewed 164 times
Recent Search Terms used to find this page:
S100A6 protein | hsp90 pterygium | hsp90 pterygium | S100B and antibody and Swant | Homo sapiens S100 calcium binding protein A6 S100A6 | apoptosis S100 calcium-binding protein A6 | S100 calcium-binding protein A6 apoptosis | calcyclin and ionizing radiation | Calcyclin cancer 2008 | .


Resources from the NCBI used on this page, NCBI's standard disclaimer applies.

 

Nothing in this website should be used in place of personal medical advice from your own qualified medical practitioner.

All rights reserved. All other trademarks recognized.
Copyright 1997-2009 - BioPortfolio Limited.