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S100A7


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Symbol:S100A7
Name(s):S100 calcium binding protein A7
Type:protein-coding
Organism:Homo sapiens
Synonyms:PSOR1, S100A7c
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17986321 psoriasin expression is transcriptionally suppressed by IFN-gamma; this effect is likely to be mediated by the activation of the STAT1 signaling pathway
17560571 These results are consistent with a role for S100A7 in modulating the immune response which may be a factor in early breast tumor progression.
16675044 segment from -1513 to -988 contains up-regulatory elements for the transcription activity of the S100A7 gene in oral squamous cell carcinoma cell
16357139 Over-expression of psoriasin is associated with breast tumor progression
16236163 Psoriasin is a potent chemotactic factor and its down-regulation during inflammation might be of importance for the outcome of the disease.
12839573 S100A7 expression appears to stabilize epidermal fatty acid binding protein level in keratinocytes
17033192 Increased Psoriasin expression is associated with acne pathogenesis.
17418446 S100A7 was identified and validated as being associated with lung squamous cell carcinoma metastasis to the brain.
15201992 Aberrant expression of psoriasin is commonly seen in human breast cancer and excessively high levels are correlated with the clinical outcomes.
17159909 Central region of S100A7, including only amino acids 35-80, is sufficient for full antibacterial activity. Reduced S100A7 association with bacteria is associated with reduced antibacterial activity.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDfatty acid binding protein 5S100 calcium-binding protein A7--Pubmed
HPRDfatty acid binding protein 5S100 calcium-binding protein A7--Pubmed
BINDfatty acid binding protein 5S100 calcium-binding protein A7S100A7 interacts with EFABP.-Pubmed
HPRDS100 calcium-binding protein A7S100 calcium-binding protein A7--Pubmed
HPRDS100 calcium-binding protein A7RAN binding protein 9--Pubmed
HPRDS100 calcium-binding protein A7RAN binding protein 9--Pubmed
HPRDS100 calcium-binding protein A7COP9 signalosome subunit 5--Pubmed
HPRDS100 calcium-binding protein A7COP9 signalosome subunit 5--Pubmed
BINDS100 calcium-binding protein A7COP9 signalosome subunit 5Psor interacts with Jab1.-Pubmed

Recent Publications on S100A7:

Pubmed Logo
Structural and functional characterization of a triple mutant form of S100A7 defective for Jab1 binding.
S100A7 (psoriasin) is a calcium and zinc-binding protein implicated in...
22nd October, 2009
Department of Biochemistry and Microbiology, and Chemistry University of Protein Sci. 2009 Oct 20.
DOI Direct Link
Expression patterns of S100 proteins in melanocytes and melanocytic lesions.
S100 proteins are differentially expressed in tumours of epithelial...
16th October, 2009
Departments of Clinical Genetics, Sahlgrenska University Hospital, Melanoma Res. 2009 Aug;19(4):215-25.
DOI Direct Link
Identification and Characterization of Binding Sites on S100A7, a Participant in Cancer and Inflammation Pathways.
S100A7 (psoriasin) is a member of the S100 family of signaling proteins....
9th October, 2009
Department of Chemistry, University of Victoria, P.O. Box 3065, Victoria, Biochemistry. 2009 Nov 10;48(44):10591-10600.
DOI Direct Link
The immune response of oral epithelial cells induced by single-species and complex naturally formed biofilms.
INTRODUCTION: In the oral cavity, the surfaces are constantly exposed to a...
6th October, 2009
Department of Preventive Dentistry, Periodontology and Cariology, Oral Microbiol Immunol. 2009 Aug;24(4):325-30.
DOI Direct Link
Human hair follicle epithelium has an antimicrobial defence system that includes the inducible antimicrobial peptide psoriasin (S100A7) and RNase 7.
BACKGROUND: Hair follicle (HF) ostia represent a potential port of...
24th September, 2009
Department of Dermatology, Venereology and Allergology, University Br J Dermatol. 2009 Jul;161(1):78-89. Epub 2009 Apr 20.
DOI Direct Link

View more research publications.

BioNews Results for S100A7

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Identification and Characterization of Binding Sites on S100A7, a Participant in Cancer and Inflammation Pathw
Biochemistry:  Oct 19 2009 11:16PM Matching: s100a7

Patents:

Patents logo
US Patent No.Title
7588771 Microorganisms for therapy
6387633 Method for identifying unstable genes
6692916 Systems and methods for characterizing a biological condition or agent using precision gene expression profiles
6929730 Two dimensional microfluidic gene scanner
6942980 Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities

View more patents.

S100A7 results (if any) from reagent suppliers

Google CSE Logo
Monoclonal Antibody to Psoriasin/HID5/S100A7
The IMG-409 antibody is specific for S100A7, it recognized recombinant human S100A7 but not other closely related human S100 recombinant proteins. ...
http://www.imgenex.com/tds/IMG-409A.pdf...

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ORDERING INFORMATION
2 Apr 2008 ... S100A7 (also Psoriasin) is an 11 - 13 kDa member of the S101 family, ... Human S100A7 is 101 amino acids (aa) in length. It ...
http://www.rndsystems.com/pdf/AF4475.pdf...

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Imgenex : Psoriasin/S100A7/HID5
9 Jun 2009 ... Western blot analysis of Psoriasin/S100A7/HID5 (IMG-409A) in Breast ... Psoriasin/S100A7/HID5 overexpression is a hallmark of psoriasis. ...
http://imgenex.com/view_data_page.php?id=182...

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S100A7 - R&D Systems
S100A7 (also Psoriasin) is an 11 - 13 kDa member of the S101 family, EF-hand superfamily of Ca-binding proteins. It is produced by keratinocytes and exists
...
http://www.rndsystems.com/molecule_detail.aspx?m=3704...

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BACE (M-83) Antibody sc-10748
S100A7, a novel Alzheimer's disease biomarker with non-amyloidogenic alpha- secretase activity acts via selective promotion of ADAM-10. PLoS ONE. 4: -. ...
http://www.scbt.com/datasheet-10748-bace-m-83-antibody.html...

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Antibody : Imgenex Knowledgebase center
IMG-409A [Monoclonal Antibody to Psoriasin/HID5/S100A7] · IMG-410A [Polyclonal Antibody to TLR2 (Toll-like receptor 2)/CD282] ...
http://www.imgenex.com/knowledgebase_cat.php?id=1...

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Psoriasin (FL-101) Antibody sc-67047
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIMâ„¢ Number. Human, S100A7, 6278, 1q21.3, NM_002963 ...
http://www.scbt.com/datasheet-67047-psoriasin-fl-101-antibod...

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