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S100A8
| Symbol: | S100A8 | | Name(s): | S100 calcium binding protein A8 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | 60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MIF, MRP8, NIF, P8 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18060880 |
These data indicate that S100A8/A9-induced cell death involves Bak, selective release of Smac/DIABLO and Omi/HtrA2 from mitochondria, and modulation of the balance between pro- and anti-apoptotic proteins. |
| 17636430 |
Report showed S100A8 was expressed human bone and cartilage cells and may contribute to calcification of the cartilage matrix and its replacement with trabecular bone, and to regulation of redox in bone resorption. |
| 17069562 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17787039 |
Data suggest that S100 proteins calprotectin and S100A12 are related to radiographic changes rather than disease activity in psoriatic arthritis with low disease activity. |
| 17936757 |
The homo-oligomeric forms of S100A8 and S100A9 are readily degraded by proteases, and the preferred hetero-oligomeric S100A8/A9 complex displays a high resistance even against proteinase K degradation. |
| 17852869 |
Serum calprotectin (S100A8/S100A9)and S100A12 are increased in children with inflammatory bowel disease and indicate disease activity. |
| 17895549 |
MRP8/14 may be involved in the pathogenesis of sarcoid granulomas. The measurement of serum MRP8/14 levels is useful for the diagnosis of sarcoidosis. |
| 17644317 |
S100A8 is regulated by IL-17, dexamethasone, IL-4 and IL-13 in HaCat cells (human keratinocyte cell line) |
| 13130482 |
Since MRP-8/MRP-14 exhibit direct effects on leukocyte adhesion to the vascular endothelium, their extensive expression in the epidermis indicates an active role for these S-100 proteins in the initial phase of this systemic autoimmune disease. |
| 12645005 |
plays a prominent role in leukocyte trafficking and arachidonic acid metabolism; elevated levels of S100A8 and S100A9 in body fluids of inflamed tissues strengthen the view that these molecules are important players in fighting inflammation [review] | →View more information from publications. |
Recent Publications on S100A8: |  |
S100A8 and S100A9 expression is a crucial factor for dedifferentiation in thyroid carcinoma.
BACKGROUND: S100A8 plays a role in various functions of myeloid cells by... | 23rd October, 2009
| Department of Surgery, Kuma Hospital, 8-2-35, Shimoyamate-dori, Chuo-ku,
| Anticancer Res. 2009 Oct;29(10):4157-61.
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S100A8 and S100A9 are novel nuclear factor kappa B target genes during malignant progression of murine and human liver carcinogenesis.
The nuclear factor-kappaB (NF-kappaB) signaling pathway has been recently... | 21st October, 2009
| Division of Signal Transduction and Growth Control (A100), German Cancer
| Hepatology. 2009 Oct;50(4):1251-62.
DOI Direct Link |
Mrp-8 and -14 mediate CNS injury in focal cerebral ischemia.
Several reports have recently demonstrated a detrimental role of Toll-like... | 20th October, 2009
| Max-Planck-Institute for Molecular Genetics, Ihnestr.73, 14195 Berlin,
| Biochim Biophys Acta. 2009 Oct 14.
DOI Direct Link |
S100A8/A9: A Janus-faced molecule in cancer therapy and tumorgenesis.
Correlations exist between the abundance of S100 proteins and disease... | 20th October, 2009
| Department of Physiology, University of Manitoba, Winnipeg, Canada; MICH,
| Eur J Pharmacol. 2009 Oct 14.
DOI Direct Link |
Identification of markers that distinguish monocyte-derived fibrocytes from monocytes, macrophages, and fibroblasts.
BACKGROUND: The processes that drive fibrotic diseases are complex and... | 17th October, 2009
| Department of Biochemistry and Cell Biology, Rice University, Houston,
| PLoS One. 2009 Oct 16;4(10):e7475.
DOI Direct Link |
→View more research publications. |
S100A8 results (if any) from reagent suppliers | 
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S100A8 antibody, S100A8/A9 (MRP-8/MRP-14). CALPROTECTIN Antibody ...
Buy quality mouse igg1 S100A8 antibody (interacts with human), anti-S100A8, ... CALPROTECTIN antibody, mouse igg1 monoclonal antibody, S100A8/A9 (MRP-8/MRP-14).
http://www.genwaybio.com/product_info.php?products_id=175204...
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MONOCLONAL ANTIBODY TO HUMAN S100A8/A9 (MRP-8/MRP-14), CALPROTECTIN
heterocomplex that is not exposed on the individual subunits S100A8 (MRP8) or S100A9 (MRP14). ... The S100A8/A9 complex has antibacterial, antifungal and ...
http://www.hbt.nl/HM2156.pdf...
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Calprotectin/S100A8/A9, Clone 27E10, Human mAb
S100A8/A9 heterocomplex that is not exposed on the individual subunits S100A8 ... The S100A8/A9 complex has antibacterial, antifungal and ...
http://www.cellsciences.com/PDF/HM2156.pdf...
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Mouse S100A8 Affinity Purified Polyclonal Ab
S100A8 contains short sequential modules, including an N-terminal ... This antibody has been selected for its ability to recognize mouse S100A8 in the ...
http://www.rndsystems.com/pdf/AF3059.pdf...
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S100A8 monoclonal antibody (M01)
S100A8 (AAH05928, 1 a.a. ~ 94 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Other Names: 60B8AG, CAGA, CFAG, CGLA, ...
http://www.abgent.com/products/catalog_no/AT3763a_S100A8_mon...
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Immunohistochemistry : S100A8 - R&D Systems
This antibody detects mouse S100A8. In direct ELISAs and Western blots, this antibody shows 40% cross-reactivity with recombinant human S100A8 and no ...
http://www.rndsystems.com/ihc_molecule_images.aspx?m=2935...
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HUMAN Calprotectin/S100A8/A9 ELISA Kit
Calprotectin, also known as MRP-8/MRP-14 or S100A8/A9 heterocomplex, ... binding , migration inhibitory factor-related proteins, MRP-8 (S100A8) and MRP-14 ...
http://www.cellsciences.com/PDF/HK325.pdf...
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