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S100A12


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Symbol:S100A12
Name(s):S100 calcium binding protein A12
Type:protein-coding
Organism:Homo sapiens
Synonyms:CAAF1, CAGC, CGRP, ENRAGE, MRP6, p6
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17787039 Data suggest that S100 proteins calprotectin and S100A12 are related to radiographic changes rather than disease activity in psoriatic arthritis with low disease activity.
18050248 Calculating the S100A12:sRAGE ratio might help to detect patients with KD who are at risk of being unresponsive to IVIG therapy.
17852869 Serum calprotectin and S100A12 are increased in children with inflammatory bowel disease and indicate disease activity.
11884208 Circulating CGRP in fulminant hepatic failure seems to reflect hemodynamic changes in the systemic rather than in the cerebral circulation.
11884210 Deficiency of CGRP in Familial Dysautonomia patients may explain some of their symptoms.
12218151 Proinflammatory myeloid-related protein S100A12 induces a dose- and time-dependent activation of the HIV-1 long terminal repeat promoter region that can be blocked by specific polyclonal antibody and by physical denaturation of the protein.
16253391 This study indicates a potential role for pro-inflammatory S100A9 and S100A12 in pathogenesis caused by inflammation and protein complex formation in Alzheimer's disease
16804393 Fecal S100A12 is expressed in feces of children with Crohn's disease
16864903 the function of S100A12 is suppressed by olopatadine in THP-1 monocytes
17158877 Ca2+ binding creates two symmetric hydrophobic surfaces on Ca2+-calgranulin C that allow calgranulin C to bind to the C-type immunoglobulin domain of the receptor for advanced glycation products (RAGE).

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDRAGES100 calcium-binding protein A12--Pubmed
HPRDadvanced glycosylation end product-specific receptor isoform 1 precursorCalgranulin C--Pubmed
HPRDCalgranulin Ccalcyclin binding protein isoform 1--Pubmed
HPRDS100 calcium-binding protein A12Siah1 interacting protein--Pubmed
HPRDS100 calcium-binding protein A12S100 calcium-binding protein A12--Pubmed

Recent Publications on S100A12:

Pubmed Logo
S100A12 Mediates Aortic Wall Remodeling and Aortic Aneurysm.
Rationale: S100A12 is a small calcium binding protein that is a ligand of...
31st October, 2009
Department of Medicine, Section of Cardiology; and Department of Surgery, Circ Res. 2009 Oct 29.
DOI Direct Link
Hyperglycemia-Induced Reactive Oxygen Species Increase Expression of RAGE and RAGE Ligands.
Objective - RAGE interacts with the endogenous ligands S100 calgranulins...
17th October, 2009
Department of Medicine, Diabetes Research Center, Albert Einstein College Diabetes. 2009 Oct 15.
DOI Direct Link
The crystal structures of human S100A12 in apo form and in complex with zinc: new insights into S100A12 oligomerisation.
The functions of the members of the S100 family of EF-hand proteins are...
26th September, 2009
Structural Biology Laboratory, Department of Chemistry, University of J Mol Biol. 2009 Aug 21;391(3):536-51. Epub 2009 Jun 6.
DOI Direct Link
Establishment of in vitro binding assay of high mobility group box-1 and S100A12 to receptor for advanced glycation endproducts: heparin's effect on binding.
Interaction between the receptor for advanced glycation end products...
25th September, 2009
Shanghai University of Traditional Chinese Medicine, Shanghai 201-203, Acta Med Okayama. 2009 Aug;63(4):203-11.
Neutrophil-derived S100A12 as novel biomarker of inflammation in Familial Mediterranean Fever.
OBJECTIVE: Familial Mediterranean Fever (FMF) is characterized by...
19th September, 2009
Pediatric Pneumology and Immunology, Charite University Hospital Berlin, Ann Rheum Dis. 2009 Sep 17.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Dissection of Staphylococcus Aureus Infection From Colonization in Cystic Fibrosis Patients

Patents:

Patents logo
US Patent No.Title
7611839 Methods for diagnosing RCC and other solid tumors
7308364 Diagnosis of multiple myeloma on gene expression profiling
7285530 Use of SERP-1 as an antiplatelet agent
7258857 Rage-related methods for treating inflammation
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector

View more patents.

S100A12 results (if any) from reagent suppliers

Google CSE Logo
S100A12 antibody (ab37657) | Abcam
Rabbit polyclonal to S100A12. S100 family proteins are acidic low molecular weight proteins containing 2 EF-hand calcium binding domains.
http://www.abcam.com/S100A12-antibody-ab37657.html...

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EN-RAGE/S100A12 - R&D Systems
EN-RAGE/S100A12. EN-RAGE, also named S100 calcium-binding protein A12, calcium- binding protein in amniotic fluid (CAAFl), calgranulin-related protein (CGRP)
...
http://www.rndsystems.com/molecule_detail.aspx?m=1365...

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S100A12 antibodies: Immunology > Secreted Molecules > Other ...
S100A12 antibodies. ... S100A12 antibody [19F5]. WB. Mouse monoclonal. Reacts with: Hu. Terms and conditions · Legal · Privacy policy · Investor relations ...
http://www.abcam.com/index.html?t=160569&pt=1&c=3656&ei=&mu=...

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E1032 Anti-EN-RAGE antibody produced in goat affinity isolated ...
immunoblotting: 0.1-0.2 μg/mL. immunohistochemistry: 5-15 μg/mL. indirect ELISA: 0.5-1.0 μg/mL. Gene Information, human ... S100A12(6283). storage temp. ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...

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Calgranulin C (19F5) Antibody sc-101347
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, S100A12, 6283, 1q21.3, NM_005621 ...
http://www.scbt.com/datasheet-101347-calgranulin-c-19f5-anti...

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Antibodies to Extracellular Matrix Proteins
E1032, Anti-EN-RAGE antibody produced in goat, (polyclonal), affinity isolated antibody, human ... S100A12(6283), human, ELISA (i), FACS, IHC, WB, pricing ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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Quantikine Human RAGE ELISA
EN-RAGE/S100A12 or S100B induces signal transduction events mediated by NFkB, leading to induction of pro-inflammatory cytokines including TNF-a (5). ...
http://www.rndsystems.com/pdf/DRG00.pdf...

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