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S100B


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Symbol:S100B
Name(s):S100 calcium binding protein B
Type:protein-coding
Organism:Homo sapiens
Synonyms:NEF, S100, S100beta
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18173564 Serum S100b (astrocyte-specific protein) is a useful marker of hepatic encephalopathy in patients with fulminant hepatitis.
17984171 upregulated expression of chromosome 21 genes such as S100B and amyloid precursor protein activated the stress response kinase pathways, and furthermore, could be linked to upregulation of the water channel aquaporin 4 in Down syndrome neural progenitors
18039581 The approach allows the use of small animal PET and provides novel probes to delineate functional expression of RAGE under normal and pathophysiological conditions in rodent models of disease.
15670788 Observational study of gene-disease association. (HuGE Navigator)
17525977 Observational study of gene-disease association. (HuGE Navigator)
17579612 Observational study of gene-disease association. (HuGE Navigator)
17984926 A significant increase of S-100B protein blood plasma concentrations was seen in patients with severe stroke; S-100 protein blood plasma concentration assessed on the 1st day after the stroke has highest diagnostic utility.
17984939 The difference between the evening and morning S100B levels correlated negatively with apnea/hyponea index and oxygen desaturation index and positively with basal saturation and average minimal oxygen saturation.
17525977 Genetic variants within S100B are associated with bipolar affective disorder with psychosis
18181515 The low levels of S100b detected using the present assay, despite its high sensitivity and despite the routine use of cardiotomy suction, suggest that the assay may have higher specificity for cerebral S100b than previously used assays.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDadvanced glycosylation end product-specific receptor isoform 1 precursorS100 calcium binding protein, beta--Pubmed
HPRDannexin VI isoform 1S100 calcium binding protein, beta--Pubmed
HPRDdesminS100 calcium binding protein, beta--Pubmed
HPRDglial fibrillary acidic proteinS100 calcium binding protein, beta--Pubmed
HPRDmicrotubule-associated protein tau isoform 1S100 calcium binding protein, beta--Pubmed
HPRDmicrotubule-associated protein tau isoform 1S100 calcium binding protein, beta--Pubmed
BINDS100 calcium binding protein A1S100 calcium-binding protein, betaS100A1 interacts with S100B.-Pubmed
HPRDS100A6 proteinS100 calcium-binding protein, beta--Pubmed
BINDS100 calcium-binding protein A6S100 calcium-binding protein, betaS100A6 interacts with S100B.-Pubmed
HPRDS100 calcium binding protein A11S100 calcium-binding protein, beta--Pubmed

Recent Publications on S100B:

Pubmed Logo
Differential effects of dietary fatty acids on the cerebral distribution of plasma-derived apo B lipoproteins with amyloid-beta.
Some dietary fats are a risk factor for Alzheimer's disease (AD) but the...
29th October, 2009
Faculty of Health Science, School of Public Health, Curtin University of Br J Nutr. 2009 Oct 28:1-11.
DOI Direct Link
[Cellular microparticles, potential useful biomarkers in the identification of cerebrovascular accidents.]
The clinical utility of biomarkers depends on their ability to identify...
24th October, 2009
Inserm U919, Serine proteases et physiopathologie de l'unite Med Sci (Paris). 2009 Oct;25(10):843-6.
Relationship of serum S100B levels and intracranial injury in children with closed head trauma.
OBJECTIVE: To determine if serum levels of S100B are higher in children...
24th October, 2009
Section of Pediatric Emergency Medicine, Department of Pediatrics, Yale Pediatrics. 2009 Oct;124(4):e697-704. Epub 2009 Sep 28.
DOI Direct Link
Neonatal S100B protein levels after prenatal exposure to selective serotonin reuptake inhibitors.
OBJECTIVE: This study investigated neonatal S100B levels as a biomarker of...
24th October, 2009
Department of Pediatrics, University of British Columbia, Vancouver, Pediatrics. 2009 Oct;124(4):e662-70. Epub 2009 Sep 28.
DOI Direct Link
Diagnostic value of S100B and neuron-specific enolase in mild pediatric traumatic brain injury.
OBJECT: During recent years, several biomarkers have been introduced for...
21st October, 2009
Department of Pediatric Surgery, University of Leipzig, Germany. J Neurosurg Pediatr. 2009 Oct;4(4):339-44.
DOI Direct Link

View more research publications.

BioNews Results for S100B

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Outcome prediction in traumatic brain injury: comparison of neurological status, CT findings, and blood levels of S100B and GFAP
MDLinx:  Oct 7 2009 2:02PM Matching: s100b
Diagnostic value of S100B and neuron-specific enolase in mild pediatric traumatic brain injury
MDLinx:  Oct 6 2009 10:12AM Matching: s100b
Method for diagnosis of sepsis by determination of S100B
PharmCast:  Aug 18 2009 3:55AM Matching: s100b

Clinical Trials:

Clinical Trials Logo
Urine Concentration of S100B in Extremely Premature Infants

Patents:

Patents logo
US Patent No.Title
7259607 Integrated semiconductor memory with clock generation
7374891 Methods to identify compounds that modulate rage
7392140 Cellular fibronectin as a diagnostic marker in stroke and methods of use thereof
7393833 Chimeric proteins with phosphatidylserine binding domains
7396654 Neural proteins as biomarkers for traumatic brain injury

View more patents.

S100B results (if any) from reagent suppliers

Google CSE Logo
BioVendor R&D - Molecules \ S100B
S-100B protein is a member of highly homologous acidic calcium and zinc binding proteins family (S100 family) that possess two EF-hand motifs. ...
http://www.biovendor.com/molecule/s100b...

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S100 beta antibody [SB6] (ab16959) | Abcam
Mouse monoclonal [SB6] to S100 beta. S100 beta is a member of the S100 family of proteins containing 2 EF-hand calcium binding motifs.
http://www.abcam.com/S100-beta-antibody-SB6-ab16959.html...

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S100B antibody, S-100 (beta-beta) Antibody, Mouse Monoclonal Antibody
Buy quality mouse S100B antibody (interacts with n/a), anti-S100B, S-100 (beta- beta) antibody, mouse monoclonal antibody, S-100 (beta-beta) Antibody, ...
http://www.genwaybio.com/product_info.php?products_id=240186...

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HPA015768 Anti-S100B antibody produced in rabbit Prestige ...
HPA015768 Anti-S100B antibody produced in rabbit Prestige Antibodies Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=HPA0...

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S100 antibody, S100 [4C4.9] Antibody, Mouse Monoclonal Antibody
Mouse monoclonal [4C4.9] to S100 - Astrocyte Marker; 282059; S100B; 431787; S100a1;; 282059; S100B; 431787; S100a1;, S10A1_HUMAN. [ N/A NP_006262.1 P23297 ]
...
http://www.genwaybio.com/product_info.php?products_id=192567...

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S100 antibody - Astrocyte Marker (ab868) | Abcam
S100A is composed of an alpha and beta chain whereas S100B is composed of two beta ... Bergmann glial S100B activates myo-inositol monophosphatase 1 and ...
http://www.abcam.com/s100-antibody-astrocyte-marker-ab868.ht...

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S100 beta antibody, S100 beta [SH-B1] Antibody, Mouse Monoclonal ...
Mouse monoclonal [SH - B1] to S100 beta; 282059; S100B;; Protein S100-B, S100B_HUMAN. [ N/A NP_006263.1 P04271 ]. ( GenWay 20-272-190390 online datasheet
)
http://www.genwaybio.com/product_info.php?products_id=190390...

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