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SAFB


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Symbol:SAFB
Name(s):scaffold attachment factor B
Type:protein-coding
Organism:Homo sapiens
Synonyms:DKFZp779C1727, HAP, HET, SAFB1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18154639 Over expression of HSP27 is associated with intrahepatic cholangiocarcinoma
17643427 SAFB may direct the reorganization and segregation of nuclear RNA and DNA prior to endonuclease-mediated DNA cleavage.
14587024 REVIEW: possibility that SAFB1 and SAFB2 are novel breast tumor suppressor genes, and how they might function in this role, are discussed
12837281 HSP27 is a nuclear speckle component in unstressed cells in tissue culture. It is also associated with the nucleolar compartment.
16326836 SAFB1 interacts in pull-down assays not only with PPARgamma but also with all nuclear receptors tested
16475161 PP2A-mediated dephosphorylation of HSP27 and tau correlated with PP2A-induced preservation of endothelial cell cytoskeleton
14702179 HSP27 expression may have useful diagnostic use for the prognosis of mouth squamous cell carcinoma.
15066997 SAFB1 represses ERalpha activity via indirect association with histone deacetylation and interaction with the basal transcription machinery
16195251 SAFB1 was shown to interact directly with the nuclear receptor corepressor N-CoR.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDChromodomain helicase DNA binding protein 1scaffold attachment factor B--Pubmed
HPRDchromodomain helicase DNA binding protein 1Scaffold Attachment Factor B--Pubmed
HPRDestrogen receptor 1scaffold attachment factor B--Pubmed
HPRDestrogen receptor 1scaffold attachment factor B--Pubmed
HPRDheterogeneous nuclear ribonucleoprotein A1 isoform bScaffold Attachment Factor B--Pubmed
BINDheterogeneous nuclear ribonucleoprotein D isoform bscaffold attachment factor BAUF1p42 interacts with SAF-B.-Pubmed
HPRDheterogeneous nuclear ribonucleoprotein D isoform ascaffold attachment factor B--Pubmed
HPRDheterogeneous nuclear ribonucleoprotein D isoform ascaffold attachment factor B--Pubmed
BINDheterogeneous nuclear ribonucleoprotein D isoform ascaffold attachment factor BAUF1p45 interacts with SAF-B.-Pubmed
BINDheterogeneous nuclear ribonucleoprotein K isoform ascaffold attachment factor BhnRNP K interacts with SAFB. This interaction was modeled on a demonstrated interaction between mouse proteins.-Pubmed

Recent Publications on SAFB:

Pubmed Logo
The enzymatic activity of SR protein kinases 1 and 1a is negatively affected by interaction with scaffold attachment factors B1 and 2.
SR protein kinases (SRPKs) phosphorylate Ser/Arg dipeptide-containing...
16th September, 2009
Department of Medicine, University of Thessaly, Mezourlo, 41110 Larissa, FEBS J. 2009 Sep;276(18):5212-27. Epub 2009 Aug 10.
DOI Direct Link
Utility of the virtual crossmatch in solid organ transplantation.
PURPOSE OF REVIEW: Solid-phase assays covered with single HLA molecules -...
11th September, 2009
Clinic for Transplantation Immunology and Nephrology, University Hospital Curr Opin Organ Transplant. 2009 Sep 7.
DOI Direct Link
Scaffold Attachment Factor B1 (SAFB1) heterozygosity does not influence Wnt-1 or DMBA-induced tumorigenesis.
BACKGROUND: Scaffold Attachment Factor B1 (SAFB1) is a multifunctional...
4th August, 2009
Lester and Sue Smith Breast Center, Departments of Medicine, Molecular and Mol Cancer. 2009 Mar 6;8:15.
DOI Direct Link
Clinical relevance of pretransplant donor-specific HLA antibodies detected by single-antigen flow-beads.
BACKGROUND: Defining the clinical relevance of donor-specific...
9th July, 2009
Clinic for Transplantation Immunology and Nephrology, University Hospital Transplantation. 2009 Jun 15;87(11):1681-8.
DOI Direct Link
Estradiol and tamoxifen mediate rescue of the dominant-negative effects of estrogen response element-binding protein in vivo and in vitro.
Biological responses to estrogens are dependent on the integrated actions...
9th June, 2009
Division of Endocrinology, Metabolism, and Lipids, Department of Medicine, Endocrinology. 2009 May;150(5):2429-35. Epub 2008 Dec 23.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7608395 Systemic lupus erythematosus diagnostic assay
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
7026121 Methods and compositions for diagnosing and monitoring transplant rejection
6998256 Methods of obtaining epothilone D using crystallization and /or by the culture of cells in the presence of methyl oleate
6927286 Bleomycin gene cluster components and their uses

View more patents.

SAFB results (if any) from reagent suppliers

Google CSE Logo
SAFB monoclonal antibody (M04)
SAFB (NP_002958, 111 a.a. ~ 201 a.a) partial recombinant protein with GST tag. ... Immunofluorescence of monoclonal antibody to SAFB (AT3767a) on HeLa cell ...
http://www.abgent.com/products/catalog_no/AT3767a_SAFB_monoc...

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SAFB antibodies: Chromatin and Nuclear Signaling > Chromosome ...
SAFB antibodies. ... SAFB antibody [4i59]. IHC-P, ICC, WB, IP. Mouse monoclonal. Reacts with: Hu. ab8060 · SAFB antibody [6F7]. IP, WB, ICC/IF ...
http://www.abcam.com/index.html?t=6629&pt=1&c=562&ei=&mu=ra...

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SFRS10 antibody, SFRS10 (splicing factor. arginine/serine-rich 10 ...
Subunit: Interacts with SAFB/SAFB1 (By similarity). Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SFRS10, SNRP70, SNRPA1 and SRRM1. ...
http://www.genwaybio.com/product_info.php?products_id=43597...

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Abgent - Chromatin and Regulation Antibodies - Chromatin_regulation
AP2409a, Ribophorin (RPN1) Antibody (N-term), WB, E, H, M. AT3767aNEW, SAFB monoclonal antibody (M04), ELISA,IF,IHC-P,S-ELISA,WB-Ce,WB-Re, H ...
http://www.abgent.com/products/category/nuclear_signaling/ch...

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SAF-B (F-20) Antibody sc-32002
Species, 遺伝子名, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. ヒト, SAFB, 6294, 19p13.3, NM_002967 ...
http://www.scbt.com/ja/datasheet-32002-saf-b-f-20-antibody.h...

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Abgent - Transcription and Regulation Antibodies ...
AP1199a, SAE1 Antibody (N-term), WB, IHC, E, H. AT3767aNEW, SAFB monoclonal antibody (M04), ELISA,IF,IHC-P,S-ELISA,WB-Ce,WB-Re, H ...
http://www.abgent.com/products/category/nuclear_signaling/tr...

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SAF-B (F-20) Antibody sc-32002
Humano, SAFB, 6294, 19p13.3, NM_002967 · Q15424 · 602895. Ratón, Safb, 224903, 17 D, XP_001480362, No Aplicable. Información sobre pedidos ...
http://www.scbt.com/es/datasheet-32002-saf-b-f-20-antibody.h...

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