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SERPINB3


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Symbol:SERPINB3
Name(s):serpin peptidase inhibitor, clade B (ovalbumin), member 3
Type:protein-coding
Organism:Homo sapiens
Synonyms:HsT1196, SCC, SCCA-1, SCCA-PD, SCCA1, T4-A
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
14970861 SCCA variants are overexpressed in hepatocellular carcinoma independently of tumour etiology; a novel SCCA1 variant has been identified in one third of liver tumours
16701102 SCC-Ag mRNA levels in the peripheral blood are the best predictive factor for recurrence in patients with esophageal squamous cell carcinoma who undergo curative resection.
15902720 the hydrophobicity of the reactive site loop of SCCA1 may play an important role in hepatitis B virus binding to cells
16681421 squamous cell carcinoma antigen is expressed in peripheral blood of cancer patients
12773976 concentration and the positivity rate significantly elevated with esophageal squamous cell tumor progression; differences depended on tumor size, tumor depth, lymph node status, and distant metastasis
14654899 Findings suggest that genetic diagnosis by RT-PCR based on SCCA mRNA expression may be clinically useful for detecting occult tumor cells in cervical lymph nodes.
15733534 Single nucleotide polymorphism of SCCA2 indicated that this polymorphism may underlie the difference in promoter activity between SCCA1 and SCCA2.
17523076 The expression pattern of SCCA1 in esophageal dysplasia and squamous cell carcinmoma was studied.
12975381 transfection of SCCA1 into mammalian cells (both hepatocyte-derived and of non-hepatocyte origin) results in increased HBV binding
14719077 E-cadherin mediated cell-cell adhesion maintains SCCA production through PI 3-kinase in squamous cell carcinoma.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDCathepsin Kserine proteinase inhibitor, clade B, member 3--Pubmed
HPRDcathepsin K preproproteinSCCA1--Pubmed
HPRDCathepsin Lserine proteinase inhibitor, clade B, member 3--Pubmed
HPRDcathepsin L1 preproproteinSCCA1--Pubmed
HPRDCathepsin Sserine proteinase inhibitor, clade B, member 3--Pubmed
HPRDcathepsin S preproproteinSCCA1--Pubmed

Recent Publications on SERPINB3:

Pubmed Logo
The nutrigenomics of asthma: molecular mechanisms of airway neutrophilia following dietary antioxidant withdrawal.
Depletion of antioxidants through consumption of a low antioxidant diet...
1st September, 2009
Priority Research Centre for Asthma and Respiratory Diseases, University OMICS. 2009 Oct;13(5):355-65.
DOI Direct Link
STAT6 activation by Toxoplasma gondii infection induces the expression of Th2 C-C chemokine ligands and B clade serine protease inhibitors in macrophage.
Toxoplasma gondii provoked rapid and sustained nuclear translocation of...
6th August, 2009
Department of Parasitology and the Catholic Institute of Parasitic Parasitol Res. 2009 Oct;105(5):1445-53. Epub 2009 Aug 5.
DOI Direct Link
Squamous cell carcinoma antigen-1 (SERPINB3) polymorphism in chronic liver disease.
BACKGROUND: The serpin squamous cell carcinoma antigen (SCCA, SERPINB3)...
29th May, 2009
Department of Clinical and Experimental Medicine, University of Padua, Dig Liver Dis. 2009 Mar;41(3):212-6. Epub 2008 Jul 25.
DOI Direct Link
SERPINB3, apoptosis and autoimmunity.
SERPINB3 (Squamous Cell Carcinoma Antigen, SCCA1) is a member of the...
1st April, 2009
Clinica Medica 5, Department of Clinical and Experimental Medicine, Autoimmun Rev. 2009 Dec;9(2):108-12. Epub 2009 Mar 27.
DOI Direct Link
Comparison of expression profiles induced by dust mite in airway epithelia reveals a common pathway.
BACKGROUND: Airway epithelial cells have shown to be active participants...
16th April, 2008
Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Allergy. 2008 Apr;63(4):461-7.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7537894 Methods and kits for monitoring Barrett's metaplasia
7514219 Method for distinguishing between head and neck squamous cell carcinoma and lung squamous cell carcinoma
7132264 Human serpin polypeptides
6958387 Human serpin polypeptides

SERPINB3 results (if any) from reagent suppliers

Google CSE Logo
SerpinB3 antibody (ab55733) | Abcam
Mouse monoclonal to SerpinB3. SerpinB3 is a serine proteinase inhibitor of the ovalbumin like B clade of serpins. It was first discovered as a protein ...
http://www.abcam.com/SerpinB3-antibody-ab55733.html...

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SCCA1 (8H11) Antibody sc-21767
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, SERPINB3, 6317, 18q21.33, NM_006919
...
http://www.scbt.com/datasheet-21767-scca1-8h11-antibody.html...

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SerpinB3 antibody - Amino end mature SCCA-1 (ab47726) | Abcam
Rabbit polyclonal to SerpinB3 - Amino end mature SCCA-1. SerpinB3 is a serine proteinase inhibitor of the ovalbumin like B clade of serpins.
http://www.abcam.com/SerpinB3-antibody-Amino-end-mature-SCCA...

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SPB3 Antibody (N-term)
Serpin B3; Squamous cell carcinoma antigen 1; SCCA-1; Protein T4-A; SCCA1; SCCA; SERPINB3. Application Data: Calculated MW: 44565 Da ...
http://www.abgent.com/products/catalog_no/AP6579a_SPB3_Antib...

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SCCA1 (8H11) Antibody sc-21767
... Numéro d'accès d´isoforme d´ARNm, Numéro d'accès de la protéine, Numéro OMIM ™. Humain, SERPINB3, 6317, 18q21.33, NM_006919 · P29508 ...
http://www.scbt.com/fr/datasheet-21767-scca1-8h11-antibody.h...

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Cell Biology: primary antibodies, proteins, peptides, kits | Abcam
... SERPINI2 proteins and peptides (1) · SerpinB11 antibodies (1) · SerpinB2 antibodies (2) · SerpinB2 proteins and peptides (1) · SerpinB3 antibodies (2)
...
http://www.abcam.com/index.html?cl=246&pageconfig=productmap...

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SCCA1 (8H11) Antibody sc-21767
种属, 基因名称, 基因ID, 染色质位置, 亚型(mRNA)即位号码, 蛋白质即位号码, OMIM™ 号码. 人类, SERPINB3, 6317, 18q21.33, NM_006919 · P29508 ...
http://www.scbt.com/zh/datasheet-21767-scca1-8h11-antibody.h...

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