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SCD


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Symbol:SCD
Name(s):stearoyl-CoA desaturase (delta-9-desaturase)
Type:protein-coding
Organism:Homo sapiens
Synonyms:FADS5, MSTP008, PRO0998, SCD1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
15662557 Observational study of gene-disease association. (HuGE Navigator)
17636091 Observational study of gene-disease association. (HuGE Navigator)
17852835 The results indicate that when the supply of FA to HL60 cells is limited, the intracellular content of n-3 and n-6 FA decreases and this leads to upregulation of the desaturases, D9D is doubled.
17636091 Genetic variations in the SCD1 gene are associated with body fat distribution and insulin sensitivity.
14683458 Of genes identified in the liver whose expression is modulated by leptin, stearoyl-CoA desaturase-1 ranks at the top of the list, according to this review.
14967817 relationship between triglyceride levels and the ratio of plasma oleic acid to stearic acid (the 18:1/18:0 ratio), a plasma marker of SCD activity, and n-3 PUFAs in 411 Japanese, 418 Korean, and 251 Mongolian adults
14967823 increased palmitate and stearate desaturation by stearoyl-CoA desaturase was associated with the destabilization of ABCA1 by saturated fatty acids palmitate and stearate
15855323 SCD activity index after rosiglitazone in PPARgamma mutation supports a pivotal role of PPARgamma function in SCD regulation.
15708362 Results suggest that stearoyl-CoA desaturase levels are associated with the events of neoplastic cell transformation and programmed cell death.
12061775 Inhibition of stearoyl-CoA desaturase activity by the cis-9,trans-11 isomer and the trans-10,cis-12 isomer of conjugated linoleic acid in human breast cancer cells.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDCytochrome b-5stearoyl-CoA desaturase--Pubmed
HPRDcytochrome b-5 isoform 1Stearoyl-CoA desaturase--Pubmed

Recent Publications on SCD:

Pubmed Logo
Fragmented QRS and other depolarization abnormalities as a predictor of mortality and sudden cardiac death.
PURPOSE OF REVIEW: Several invasive and noninvasive tests for risk...
3rd November, 2009
Krannert Institute of Cardiology, Indiana University School of Medicine, Curr Opin Cardiol. 2009 Oct 29.
DOI Direct Link
Maternal knowledge and attitudes about newborn screening for sickle cell disease and cystic fibrosis.
Illinois introduced mandatory newborn screening (NBS) for sickle cell...
31st October, 2009
Department of Pediatrics, University of Chicago, Chicago, Illinois. Am J Med Genet A. 2009 Oct 28;149A(11):2424-2429.
DOI Direct Link
Timing of eplerenone initiation and outcomes in patients with heart failure after acute myocardial infarction complicated by left ventricular systolic dysfunction: insights from the EPHESUS trial.
AIMS: To test the hypothesis that an earlier post-acute myocardial...
31st October, 2009
Inserm, Centre d'Investigations Cliniques CIC Inserm CHU and U961, Hopital Eur J Heart Fail. 2009 Nov;11(11):1099-105.
DOI Direct Link
Sleep apnoea induces cardiac electrical instability assessed by T-wave alternans in patients with congestive heart failure.
AIMS: To assess the involvement of sleep apnoea in nocturnal sudden...
31st October, 2009
Regeneration and Advanced Medical Science, Gifu University Graduate School Eur J Heart Fail. 2009 Nov;11(11):1063-70.
DOI Direct Link
Neuropsychological assessment of African children: evidence for a universal brain/behavior omnibus within a coconstructivist paradigm.
Cross-cultural neuropsychology with African and American children provides...
31st October, 2009
International Neurologic and Psychiatric Epidemiology Program, Michigan Prog Brain Res. 2009;178:113-35.
DOI Direct Link

View more research publications.

Press Releases on SCD:

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China Sky One Medical, Inc. Announces Record First Quarter 2009 Results 14th May, 2009 China Sky One Medical, Inc.

HARBIN, China, May 14 /PRNewswire-Asia-FirstCall/ -- China Sky One Medical, Inc. ("China Sky One Medical" or "the Company") (Nasdaq: CSKI), a leading fully integrated

China Sky One Medical, Inc. Achieves Significant Breakthrough in Research for Sudden Cardiac Death (SCD) Early Examination Kit 4th May, 2009 China Sky One Medical, Inc.

HARBIN, China, May 4 /PRNewswire-Asia-FirstCall/ -- China Sky One Medical, Inc. ("China Sky One Medical" or "the Company")

Dr. Steven L. Zelenkofske Joins Regado Biosciences as Senior Vice President, Clinical and Medical Affairs and Chief Medical Officer 15th January, 2009 Regado Biosciences, Inc.

BASKING RIDGE, N.J., Jan. 15 /PRNewswire/ -- Regado Biosciences, Inc., announced today the appointment of Steven L. Zelenkofske, D.O., F.A.C.C. to the position of Senior Vice President, Clinical

Implantable Defibrillators Lower Risk of Death in Older Heart Patients 14th January, 2009 American Heart Association

American Heart Association rapid access journal report:

Study highlights:

-- Implantable cardioverter defibrillators (ICDs) may

Heart Scan Taking Center Stage in Sudden Cardiac Death 5th August, 2008 Sacramento HeartScan

SACRAMENTO, Calif., Aug. 5 /PRNewswire/ -- Each year, more than 310,000 Americans die without even experiencing a symptom or indication of heart disease, according to a 2008 report from the

BioNews Results for SCD

: RSS Logo
BioPortfolio Logo
Texting May Cause Neck Pain
WebMD:  Nov 13 2009 5:41PM Matching: scd
Samples could solve sudden death riddle
Irish Medical Times:  Nov 12 2009 1:45AM Matching: scd
PRI's risk management conference focuses on public policy and future trends in medical malpractice
News-Medical.Net:  Nov 11 2009 11:55AM Matching: scd
Medical News: Teenage Obesity Linked To Increased Risk Of MS
BioFind:  Nov 10 2009 2:01PM Matching: scd
Teenage Obesity Linked To Increased Risk Of MS
Medical News Today:  Nov 10 2009 10:58AM Matching: scd
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Clinical Trials:

Clinical Trials Logo
A Phase 2 Study of the Effects of 6R-BH4 in Subjects With Sickle Cell Disease

Patents:

Patents logo
US Patent No.Title
7568246 Bed with a networked alarm
7580111 Liquid for immersion exposure and immersion exposure method
7580747 Inducing premature atrial contractions for the purpose of monitoring autonomic tone, risk of sudden cardiac death and ischemic events
7582293 Anti-PRO6308 antibodies
7582411 Antireflective film and exposure method

View more patents.

SCD results (if any) from reagent suppliers

Google CSE Logo
SCD Antibody / SCD Antibodies
SCD Antibody / SCD Antibodies. ... SCD specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-scd.html...

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SCD antibody [CD.E10] (ab19862) | Abcam
Mouse monoclonal [CD.E10] to SCD. Stearoyl-CoA desaturase (SCD) is a regulatory enzyme in lipogenesis. The SCD1 gene is tightly regulated by signals such as ...
http://www.abcam.com/SCD-antibody-CD-E10-ab19862.html...

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SCD (E-14) Antibody sc-30435
goat polyclonal IgG, 200µg/ml; epitope mapping within an internal region of SCD1 of mouse origin; recommended for detection of SCD of human origin, ...
http://www.scbt.com/datasheet-30435-scd-e-14-antibody.html...

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Anti-Acyl-CoA Desaturase (SCD) Monoclonal Antibody
Monoclonal Antibody against Acyl-CoA Desaturase (SCD) for use in ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot.
http://www.bioreagents.com/products/productDetails/productDe...

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BioVendor R&D - Products \ Cell surface proteins (sCD)
Cell surface proteins (sCD). 15 results found in Immunoassays. Immunoassays (15) ; Proteins (0); Antibodies (0). Molecule: ...
http://www.biovendor.com/products/research-topic/cell-surfac...

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SCD siRNA (h) sc-36464
Click here for details. suitable control antibody: SCD1 (S-15): sc-14719; sqRT- PCR Primer also available: SCD (h)-PR: sc-36464-PR, 20 µl ...
http://www.scbt.com/datasheet-36464-scd-sirna-h.html...

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SCD antibodies: Cardiovascular > Lipids / Lipoproteins > Fatty ...
SCD antibodies. ... SCD antibody [CD.E10]. IP, WB, ELISA, IHC-Fr. Images · unrated · Specific publication references. Mouse monoclonal ...
http://www.abcam.com/index.html?t=112145&pt=1&c=4460&ei=&mu=...

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