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BGN


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Symbol:BGN
Name(s):biglycan
Type:protein-coding
Organism:Homo sapiens
Synonyms:DSPG1, PG-S1, PGI, SLRR1A
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
10684260 Biglycan binds to alpha-dystroglycan and this binding requires the chondroitin sulfate side chains of biglycan.
16807372 Biglycan regulates assembly of intracellular components of the dystrophin-associated protein complex.
16883602 Biglycan binds two integral membrane proteins, alpha- and gamma- sarcoglycan, expressed in skeletal muscle and heart. Genetic studies show that the biglycan regulates expression of these sarcoglycans in juvenile (
17097211 biglycan in the umbilical cord vein wall is elevated in pre-eclampsia in comparison to the corresponding control vessels
17516017 analysis of distribution patterns of decorin and biglycan and their relation with collagen
16434404 beta ig-h3 can differentially modulate the aggregation of collagen VI with biglycan and decorin
15031262 Biglycan may be involved in vascular smooth muscle growth & migration through cdk2- & p27-dependent pathways. Changes in its expression may affect arterial susceptibility to vascular injury, & may play a direct role in pathogenesis of vascular lesions.
15372625 TGF-beta(1) stimulats human biglycan mRNA expression.
17120779 Biglycan is a positive modulator of BMP-2 induced osteoblast differentiation
15546867 TGF-beta induces biglycan expression through ALK5 and GADD45beta

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDApolipoprotein Bbiglycan preproprotein--Pubmed
HPRDapolipoprotein B precursorBiglycan--Pubmed
HPRDAmyloid beta A4 proteinbiglycan preproprotein--Pubmed
HPRDamyloid beta A4 protein precursor, isoform aBiglycan--Pubmed
HPRDBiglycansarcoglycan, alpha--Pubmed
HPRDBiglycanelastin--Pubmed
HPRDBiglycantumor necrosis factor--Pubmed
HPRDBiglycantransforming growth factor, beta 1--Pubmed
HPRDBiglycanalpha 1 type II collagen isoform 1--Pubmed
HPRDBiglycanalpha 2 type IV collagen preproprotein--Pubmed

Recent Publications on BGN:

Pubmed Logo
Biglycan expression in hypertensive subjects with normal or increased carotid intima-media wall thickness.
BACKGROUND: Biglycan (BGN), an extracellular matrix proteoglycan, has been...
24th September, 2009
Department of Internal Medicine, University of Messina,Via Camiciotti, 82, Clin Chim Acta. 2009 Aug;406(1-2):89-93. Epub 2009 Jun 10.
DOI Direct Link
Chondrogenic differentiation potential of osteoarthritic chondrocytes and their possible use in matrix-associated autologous chondrocyte transplantation.
ABSTRACT: INTRODUCTION: Autologous chondrocyte transplantation (ACT) is a...
3rd September, 2009
Tissue Engineering Laboratory and Berlin-Brandenburg Center for Arthritis Res Ther. 2009 Sep 2;11(5):R133.
DOI Direct Link
Inbred strain-specific response to biglycan deficiency in the cortical bone of C57BL6/129 and C3H/He mice.
Inbred strain-specific differences in mice exist in bone cross-sectional...
14th August, 2009
Department of Biomedical Engineering, The University of Michigan, Ann J Bone Miner Res. 2009 Jun;24(6):1002-12.
DOI Direct Link
Detection of Cytonuclear Genomic Dissociation in the North American Captive African Elephant Collection.
A total of 114 captive elephants (6 Asian; 108 African) from 43 private...
7th August, 2009
the Grewcock's Center for Conservation and Research, Omaha's Henry Doorly J Hered. 2009 Aug 5.
DOI Direct Link
Genetic evidence for key roles of decorin and biglycan in dentin mineralization.
Targeted disruption of the dentin sialophosphoprotein (DSPP) gene in the...
30th June, 2009
Functional Genomics Section, Laboratory of Cell and Developmental Biology, Matrix Biol. 2009 Apr;28(3):129-36. Epub 2009 Feb 12.
DOI Direct Link

View more research publications.

BioNews Results for BGN

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BioPortfolio Logo
Ben-Gurion University Signs R&D Agreement with German Company curasan AG
Bionity.com:  Nov 14 2009 6:29PM Matching: bgn
09:50 - Bulgaria: Sopharma 9-mo profit more than doubles to BGN 30.8 M
Reporter.gr:  Nov 4 2009 4:27AM Matching: bgn
Bulgaria: Sopharma 9-mo profit more than doubles to BGN 30.8 M
Reporter.gr:  Nov 3 2009 11:54AM Matching: bgn
Can GlaxoSmithKline nudge the FTSE 100?
Economy News:  Oct 28 2009 12:37PM Matching: bgn
36 000 New Cancer Cases Predicted for Bulgaria in 2010
Sofia News Agency:  Oct 27 2009 12:12AM Matching: bgn
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Clinical Trials:

Clinical Trials Logo
Pepsinogens as the Early Marker of H. Pylori Eradication

Patents:

Patents logo
US Patent No.Title
6807110 Semiconductor memory device
7065593 Centralized, double bandwidth, directional, shared bus communication system architecture
7088350 Display device employing time-division-multiplexed driving of driver circuits
7096027 Communication method, communication system and communication apparatus
7139860 On chip network with independent logical and physical layers

View more patents.

BGN results (if any) from reagent suppliers

Google CSE Logo
Lysozyme antibody [BGN/06/961] (ab36362) | Abcam
Mouse monoclonal [BGN/06/961] to Lysozyme. Lysozyme catalyzes the hydrolysis of certain mucopolysaccharides of bacterial cell walls.
http://www.abcam.com/Lysozyme-antibody-BGN-06-961-ab36362.ht...

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ALB (BGN/1328/33) Antibody sc-80674
ALB (BGN/1328/33): sc-80674. Western blot analysis of ALB expression in human PBL whole cell lysate. sc-80674. ALB (BGN/1328/33): sc-80674. ...
http://www.scbt.com/datasheet-80674-alb-bgn-1328-33-antibody...

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Hepatitis A Virus Surface Antigen antibody [BGN/B5B3] (ab54049 ...
Mouse monoclonal [BGN/B5B3] to Hepatitis A Virus Surface Antigen. Hepatitis A virus (HAV), the causative agent of type A viral hepatitis, ...
http://www.abcam.com/Hepatitis-A-Virus-Surface-Antigen-antib...

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Angiotensin I (BGN/KA/22H) Antibody sc-80682
Angiotensin I (BGN/KA/22H) Antibody sc-80682 Angiotensin I (BGN/KA/22H) Antibody ... Angiotensin I (BGN/KA/22H): sc-80682. Western blot analysis of ...
http://www.scbt.com/datasheet-80682-angiotensin-i-bgn-ka-22h...

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cardiac Myosin type II antibody [BGN/04/4482] (ab58913) | Abcam
Mouse monoclonal [BGN/04/4482] to cardiac Myosin type II. Most myosin molecules are composed of both a head and a tail domain. The head domain binds the ...
http://www.abcam.com/cardiac-Myosin-type-II-antibody-BGN-04-...

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BGN monoclonal antibody (M02)
BGN (AAH02416, 1 a.a. ~ 369 a.a) full length recombinant protein with GST tag. ... Western Blot analysis of BGN expression in transfected 293T cell line by ...
http://www.abgent.com/products/catalog_no/AT1296a_BGN_monocl...

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Alkaline Phosphatase antibody [BGN/03/661] (ab58959) | Abcam
Mouse monoclonal [BGN/03/661] to Alkaline Phosphatase . Alkaline phosphatase ( ALP) removes phosphate groups from the 5' end of DNA and RNA, ...
http://www.abcam.com/Alkaline-Phosphatase-antibody-BGN-03-66...

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