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SCN9A
| Symbol: | SCN9A | | Name(s): | sodium channel, voltage-gated, type IX, alpha subunit | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | ETHA, NE-NA, NENA, Nav1.7, PN1 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18060017 |
highlights of recent developments and discussion of the critical role of Na(v)1.7 in pain sensation in humans [review] |
| 17950472 |
The contribution of Na(v)1.7 to acquired and inherited pain states and the absence of motor, cognitive and cardiac deficits in patients lacking this channel make it an attractive target for the treatment of neuropathic pain. |
| 18070139 |
review: a series of SCN9A mutations resulting in gain-of-function phenotypes presenting with the phenotype of enhanced pain sensitivity. |
| 18070140 |
review: Congenital Indifference to Pain patients assessed are homozygous or compound heterozygous for nonsense mutations at various locations throughout SCN9A, resulting in an early stop codon |
| 17985268 |
This study describe a boy with erythermalgia whose painful attacks began in infancy. We found a novel mutation of SCN9A. |
| 18036246 |
VGSC activity has a significant intermediary role in potentiating effect of EGF in human prostate cancer |
| 17928139 |
In rectal hypersensitivity, Na(v)1.7 immunoreactive nerve fibres were significantly increased in mucosal, sub-mucosal, and muscle layers |
| 17597096 |
A stop codon mutation in SCN9A causes lack of pain sensation. |
| 17404832 |
results suggest that the enhancement of TTX-sensitive sodium current density in differentiated NG108-15 cells is mainly due to the increase in the expression of the TTX-sensitive voltage-gated Na+ channel, NaV1.7 |
| 17430993 |
Mutations in SCN9A may mediate variabiilty in lidocaine sensitivity in erythromelalgia patients. | →View more information from publications. |
Recent Publications on SCN9A: |  |
Developments in autonomic research: a review of the latest literature.
Small-diameter afferents do not just subserve pain and temperature... | 22nd October, 2009
| School of Medicine, University of Western Sydney, Penrith South DC, NSW
| Clin Auton Res. 2009 Aug;19(4):193-6.
DOI Direct Link |
Absence of pain with hyperhidrosis: A new syndrome where vascular afferents may mediate cutaneous sensation.
Congenital absence of pain perception is a rare phenotype. Here we report... | 20th October, 2009
| Pain Research Institute, Liverpool L9 7AL, UK.
| Pain. 2009 Oct 14.
DOI Direct Link |
Voltage-gated sodium channels: therapeutic targets for pain.
OBJECTIVE: To provide an overview of the role of voltage-gated sodium... | 13th October, 2009
| Department of Neurology and Center for Neuroscience and Regeneration
| Pain Med. 2009 Oct;10(7):1260-9.
DOI Direct Link |
A role of SCN9A in human epilepsies, as a cause of febrile seizures and as a potential modifier of Dravet syndrome.
A follow-up study of a large Utah family with significant linkage to... | 19th September, 2009
| Department of Human Genetics, University of Utah, Salt Lake City, Utah,
| PLoS Genet. 2009 Sep;5(9):e1000649. Epub 2009 Sep 18.
DOI Direct Link |
Sodium channelopathy of peripheral nerve: tightening the genotype-phenotype relationship.
Summary Primary erythermalgia (erythromelalgia) is a rare autosomal... | 10th September, 2009
| UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.
| Brain. 2009 Jul;132(Pt 7):1690-2. Epub 2009 May 8.
DOI Direct Link |
→View more research publications. |
SCN9A results (if any) from reagent suppliers | 
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Antibodies to Sodium Channels
affinity isolated antibody, rat ... Scn9a(78956) human ... SCN9A(6335), rat, WB CL, pricing. S0438, Anti-Sodium Channel PN4 antibody produced in rabbit ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...
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Na+ CP type IXα (H-17) Antibody sc-130096
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, SCN9A, 6335, 2q24.3, Q15858 ...
http://www.scbt.com/datasheet-130096-na-cp-type-ixalpha-h-17...
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S8809 Monoclonal Anti-Sodium Channel, Pan antibody produced in ...
Scn10a(20264), Scn11a(24046), Scn1a(20265), Scn3a(20269), Scn4a(110880), Scn5a( 20271), Scn8a(20273), Scn9a(20274). shipped in, wet ice. storage temp. −20°C
...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=S880...
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Na+ CP type IXα (H-17) Antibody sc-130096
Species, Nome del gene, Codice del gene, Locus cromosoma, Isoform (mRNA) Accession #, codice accesso proteina, Numero d' ordine. Human, SCN9A, 6335, 2q24
.3 ...
http://www.scbt.com/it/datasheet-130096-na-cp-type-ixalpha-h...
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Complete Solutions for Ion Channels
SCN9A, NM_002977, sodium channel: voltage-gated type IX: alpha, S0645. SCN8A, NM_014191, sodium channel: voltage-gated type VIII: alpha, S0438 ...
http://www.sigmaaldrich.com/life-science/functional-genomics...
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Na+ CP type IXα (H-17) Antibody sc-130096
... Numéro d'accès de la protéine, Numéro OMIM™. Humain, SCN9A, 6335, 2q24.3, Q15858 · 603415. Souris, Scn9a, 20274, 2 C1.3, Q62205, Non disponible ...
http://www.scbt.com/fr/datasheet-130096-na-cp-type-ixalpha-h...
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Na+ CP type IXα siRNA (m) sc-149784
Species, 遺伝子名, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. マウス, Scn9a, 20274, 2 C1.3, Q62205 ...
http://www.scbt.com/ja/datasheet-149784-na-cp-type-ixalpha-s...
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